iiinova — where your digital self keeps evolving

Sahana Holla @sahanaholla.bsky.social · 07/01/2026

Stress makes memories...epigenetically speaking!! A histone ubiquitylation “stress switch” lets environmental signals lock into heterochromatin, passing on epigenetic memories long after the stress is gone. Fantastic story! Congrats @grewalsh.bsky.social‬ @bharat-bhatt.bsky.social and team! 👏👏

010

Reposted by Sahana Holla

Shiv Grewal @grewalsh.bsky.social · 07/01/2026

Stress controls epigenetic inheritance! A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance, and cancer 👉 nature.com/articles/s41586-025-09899-8

Read in Nature: nature.com/articles/s41586-025-09899-8

33622

Sahana Holla @sahanaholla.bsky.social · 01/07/2025

Grateful for the warm welcome @tifrhyderabad.bsky.social :) Thrilled to be part of this vibrant scientific community and eager to build an exciting research program!

022

Reposted by Sahana Holla

Shiv Grewal @grewalsh.bsky.social · 29/06/2025

So proud of you, @sahanaholla! Watching your journey has been such a joy. Wishing you all the best as you begin this exciting new chapter at TIFRH. They’re lucky to have you!

152

Sahana Holla @sahanaholla.bsky.social · 29/06/2025

Thrilled to share that I’ve joined @tifrhyderabad.bsky.social as an Assistant Professor! Grateful to my mentors (esp @grewalsh.bsky.social and KN Balaji), colleagues, friends, family & EVERYONE who made this possible. Excited to explore Epigenetics & the 3D Genome with the brilliant minds in India!

292

Reposted by Sahana Holla

Shiv Grewal @grewalsh.bsky.social · 03/01/2025

🎉 CONGRATULATIONS to Manjit Srivastav, Diego Folco, Patroula Nathanailidou, Anupa Anil, Drisya Vijaykumari, Shweta Jain, Jothy Dhakshnamoorthy, David Wheeler, and our amazing collaborators Maura O’Neill and Thorkell Andresson! Your unwavering dedication, hard work, and passion are truly inspiring 🙌✨

131

Reposted by Sahana Holla

Shiv Grewal @grewalsh.bsky.social · 03/01/2025

🔬Decoding Silencing: How Heterochromatin Transcribes to Silence Itself! 🧬 Discover how a pioneer transcription factor-like complex infiltrates repressive heterochromatin, producing transcripts with hidden introns that kickstart RNAi-mediated heterochromatin formation www.nature.com/articles/s41...

17134

Reposted by Sahana Holla

Daniel Ibrahim @danielibrahim.bsky.social · 28/11/2024

🔺🔺🔺RED TRIANGLE ALERT 🔺🔺🔺 Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!! Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals! SMCs & RNA-Pol are the only thing they have in common www.nature.com/articles/s41...

nature.com

Evolution and function of chromatin domains across the tree of life - Nature Structural & Molecular Biology

Szalay et al. discuss cross-kingdom similarities and differences in 3D chromatin folding in relation to gene regulation, including in bacteria, archaea, mammals and plants. This comparison reveals cer...

320684

Reposted by Sahana Holla

Maxim Greenberg @maxvcg.bsky.social · 26/11/2024

Very happy to see @grothlab.bsky.social , @helink.bsky.social and @grewalsh.bsky.social all migrating over here! All pillars of the the #epigenetics and chromatin community.

2314