For the 20th century, I’m tempted to say June 6, 1944, but the real answer is probably some date in December, 1999 as the Internet is increasingly adopted
❀°。Der Siebenschläfer *.ﾟ✿ ⋆
@sababausa.bsky.social
6.7K followers 1.3K following 34K posts
30-something Jewish 🇺🇸 🇦🇹 dual-citizen biologist patent lawyer who grew up in South Jersey, Delaware, and Geneva 🇨🇭. Now in Northern Virginia Proud dad to twin daughters 👶👶
![The mainstay of treatment for methanol intoxication is administration of ethanol [30, 31]. The enzymes responsible for converting methanol to formaldehyde and formic acid are also involved in the metabolism of ethanol to acetaldehyde and acetate. The two alcohols there-
fore act as competitive substrates. However, the rate of
metabolism of methanol by these enzymes is only a frac-
tion of that of ethanol [25, 32-34]. Thus, conversion of
methanol into its toxic byproducts is slowed in the pres-
ence of ethanol. Typical criteria for initiating ethanol
treatment include all patients with peak serum methanol
concentrations greater than 20mg/dl and all patients
with acidosis ascribed to methanol intoxication, regard-
less of whether or not symptoms are present [25]. Be-
cause methanol assay results may not be immediately
available, it is important to initiate ethanol therapy in pa-
tients with a clear history of methanol ingestion and in
patients strongly suspected of methanol poisoning.
The clinical goal of ethanol therapy is to achieve a
therapeutic serum ethanol level of between 100 and ap-
proximately 150mg/dl [16, 25, 31, 35, 36]. This concen-
tration is necessary to saturate alcohol dehydrogenase
[36, 37]. Some reviewers have recommended up to](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:eoss3vmzem55cm5kuddhdmwn/bafkreibw6wiwonclx4oplxi7yuzcsne72bskvrwluijyfqnay3dvah4soi)
![Liberty, egality, fraternity; they forgot obligations and duties I think, And then of course it was the fraternity that wet missing for a long time. Well, it just did, did it not? It heralded an age of terror. Lend p17]
It has been fascinating and the books that have been written about it. I remember having read there were only seven people in the Bastille the night it was stormed. It was quite an extraordinary thing.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:eoss3vmzem55cm5kuddhdmwn/bafkreieaywmbeozbdprkkv7avqnulh6eu3yjfqvaltf7pgsxg5qvnake24)
