The application of therapeutic RNAs, such as miRNAs, siRNAs, and mRNAs, has emerged as a promising therapeutic approach for treating diseases like cancer.

Biopolymer nanoparticles have emerged as promising carriers for bioactive agents, offering sustained or controlled release and improved biocompatibility. The purpose of this study was to design novel ...

Chitosan is a widely applied polysaccharide in different fields due to its versatility, biocompatibility and low toxicity. Its structure possesses reactive functional groups that can be modified witho...

The traditional treatment of stomach cancer is based on a combination of surgery and chemo/radiotherapy leading to severe side effects and endless pain. The objective of this study is the development ...

Lumefantrine and artemether are currently used as one of the first line therapies for treatment of uncomplicated malaria. However, commercially-available lumefantrine/artemether tablets often result i...

Valproic acid (VPA) is a potent antiseizure medication and mood stabilizer, yet its teratogenicity severely limits safe use during pregnancy. Despite guidelines advising against VPA use in women of re...

Effervescent tablets are solid pharmaceutical dosage forms that are widely accepted due to their advantages. The improvement in patient compliance results from a combination of factors related to both...

One of the most interesting applications of artificial intelligence is in the design of drug delivery systems. Smart drug delivery systems can transfer drugs to specific tissues and cells, enhancing t...

Tracking nanoparticles’ location is imperative for understanding cellular interactions, pharmacokinetics, and biodistribution. DiD is a lipophilic dye commonly used to label nanoparticles for traffick...

Applying lipid nanoparticle (LNP) technology to ribonucleic acid (RNA) nanomedicines was integral to the success of mRNA vaccines against COVID-19. To expand the power of LNP technology, extrahepatic ...

Digitalization is transforming the pharmaceutical industry, offering innovative solutions to enhance sustainability across the pharmaceutical value chain. From drug discovery to patient care, digital ...

Poly(β-amino ester) (PBAE)-based nanoparticles have emerged as promising carriers for RNA delivery, yet clear design rules linking formulation parameters to performance are still lacking. In this…

The COVID-19 pandemic underscored the urgent need for advanced drug delivery systems to enhance the safety and efficacy of existing antiviral therapies. This study presents an inhalable powder formula...

Levodopa (LD) remains the most effective therapy for Parkinson's disease; however, its short plasma half-life necessitates frequent dosing and contributes to fluctuating drug levels and motor complica...

Lipid nanoparticles (LNPs) are self-assembled nanocarriers made up of ionizable cationic lipids, membrane lipids, sterols, and PEGylated lipids in a predetermined proportion to encapsulate nucleic aci...

Engineered living materials (ELMs), which integrate live microorganisms into biocompatible matrices, are emerging as powerful platforms for therapeutic applications. Among these, hydrogels encapsulati...