iiinova — where your digital self keeps evolving

Reposted by Natalia Nombera Aznaran

Nephrology Journal Club @nephjc.bsky.social · 16/01/2026

1/10 Last #NephJC we discussed Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN #TenPostNephJC Given the central role of complement dysregulation in C3 glomerulonephritis, we assessed whether complement-targeted therapies confer therapeutic benefit. www.nejm.org/doi/full/10....

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Natalia Nombera Aznaran @roxnonna23.bsky.social · 14/01/2026

Maybe as an early option for biopsy proven recurrent with proteinuria, declining egfr and active lesions. Not as first line though for low grade proteinuria. #NephJC

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Natalia Nombera Aznaran @roxnonna23.bsky.social · 14/01/2026

Let’s keep in mind that VALIANT had less than 10% history of transplant #NephJC

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Natalia Nombera Aznaran @roxnonna23.bsky.social · 14/01/2026

We need to see longer follow up recurrence, progression to ESKD. Maybe sequential or switching for partial responders or intolerant but still food for thought #NephJC

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Natalia Nombera Aznaran @roxnonna23.bsky.social · 14/01/2026

Yes and because it was hierarchical design they couldn’t get conclusion for the other outcomes - staining #NephJC

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Natalia Nombera Aznaran @roxnonna23.bsky.social · 14/01/2026

Even if they started with lower UPCR in the placebo, the shift is good in intervention vs placebo! #NephJC

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Natalia Nombera Aznaran @roxnonna23.bsky.social · 14/01/2026

Change in activity score didn’t differ though 🧐 #NephJC

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Natalia Nombera Aznaran @roxnonna23.bsky.social · 14/01/2026

Pts with intervention had lower egfr and higher UPCR 🧐🧐 #NephJC

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Natalia Nombera Aznaran @roxnonna23.bsky.social · 14/01/2026

Not all completed the open label period 🧐 #NephJC

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Reposted by Natalia Nombera Aznaran

Nephrology Journal Club @nephjc.bsky.social · 14/01/2026

🎨Beautiful visual abstract by Dr Akshaya Akshaya Jayachandran #NephJC

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Natalia Nombera Aznaran @roxnonna23.bsky.social · 14/01/2026

Hi Natalia Nombera here 🙌🏼🙌🏼 No COI Just a Stranger Things fan! #NephJC

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Reposted by Natalia Nombera Aznaran

Juan Carlos Q Vélez, MD @juancarlosqvelez.bsky.social · 21/11/2025

7. Personal level. Beyond his talent and expertise, I met an extraordinary man. Humble, altruistic, wise, friendly, and with a great sense of humor. I brought him a vacuolar cast tie as a present and he wore it proudly right away 🤩

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Reposted by Natalia Nombera Aznaran

Juan Carlos Q Vélez, MD @juancarlosqvelez.bsky.social · 21/11/2025

6. Prof. Fogazzi. Definitely a big highlight for me was to meet for the 1st time Dr Giovanni Fogazzi, an icon in the field. Still remember when I bought his book early in my career. One my fave pics is this one that captured a moment when he stood up to ask a ? after my talk. Very cool. #BigFan

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Reposted by Natalia Nombera Aznaran

Juan Carlos Q Vélez, MD @juancarlosqvelez.bsky.social · 21/11/2025

1/n Recently attended an international congress about Urinalysis in Santiago, Chile 🇨🇱. I was expecting a small meeting. I was wrong. Pleasantly surprised with the size of the meeting and the energy and interest from the participants. Let me share the highlights of my experience:

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Reposted by Natalia Nombera Aznaran

Hemily Zandybell, MD @zandybellnefro.bsky.social · 06/11/2025

Day 1, #kidneywk 25, We attended the poster presentation, which focused on an important topic: Reducing gaps and strengthening training in urinary sediment analysis. We were joined by someone passionate about U-sed. @juancarlosqvelez.bsky.social , @roxnonna23.bsky.social .

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Reposted by Natalia Nombera Aznaran

Nephrology Journal Club @nephjc.bsky.social · 29/10/2025

Problem here is - especially in places like ours (India), affordability remains a problem - with the amount they spend on a biopsy they could afford 6 months of non immune therapy - so our biopsies are probably- At diagnosis and then only when absolutely indicated #NephJC

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Reposted by Natalia Nombera Aznaran

Nephrology Journal Club @nephjc.bsky.social · 29/10/2025

🎨Beautiful visual abstract by Dr Natalia Nombera @roxnonna23.bsky.social #NephJC www.nephjc.com/news/...

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Reposted by Natalia Nombera Aznaran

Assad SM @assadsm.bsky.social · 01/10/2025

Fascinating finding: many patients lost chimerism but stayed IS-free. 🤔 This suggests chimerism is a transient 'switch' to turn on tolerance, not the long-term mechanism itself. We urgently need to identify that mechanism for safer weaning protocols. #NephJC

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Reposted by Natalia Nombera Aznaran

Nephrology Journal Club @nephjc.bsky.social · 01/10/2025

T0J Lets learn about the GVHD - the lethal complication of transfer of immunocompetent cells to the immunosuppressed recipient. #NephJC

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Reposted by Natalia Nombera Aznaran

Nephrology Journal Club @nephjc.bsky.social · 01/10/2025

T0h A Chimera was an ancient beast with 🦁,🐐, and 🐍 parts. In modern times, genetic chimerism has been used to create immune tolerance. Infusion of donor hematopoietic stem cells & the presence of the cells in the recipient's blood stream, has been shown to induce functional tolerance. #NephJC

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Reposted by Natalia Nombera Aznaran

Nephrology Journal Club @nephjc.bsky.social · 01/10/2025

T0f Immune tolerance is defined as “a state of indifference or non-reactivity towards a substance that would normally be expected to excite an immunological response.” This is one potential strategy that would allow withdrawal of immunosuppressive medications. #NephJC

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Reposted by Natalia Nombera Aznaran

Nephrology Journal Club @nephjc.bsky.social · 01/10/2025

T0d Look at the mortality of renal transplant recipients with graft and without graft function. Top 3: 1) Cardiovascular mortality, 2) Infections, 3) Cancers All three of these are aggravated by immunosuppressive drugs (ANZADATA registry- 2300 patients) #NephJC

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Natalia Nombera Aznaran @roxnonna23.bsky.social · 01/10/2025

For now, the key is prevention of kidney disease #NephJC

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Natalia Nombera Aznaran @roxnonna23.bsky.social · 01/10/2025

Hi! Natalia Nombera, research scholar from UAB #NephJC 🐐🦁🐍

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Reposted by Natalia Nombera Aznaran

Hemily Zandybell, MD @zandybellnefro.bsky.social · 22/09/2025

👩🏻 48-year-old woman 📌 History: membranous nephropathy, hypothyroidism, morbid obesity 📈 Admitted for: Massive proteinuria: 10 g/24 h 🧪 Creatinine: 1.4 mg/dL 🟡 Automated urine: no red blood cells We performed urinary sediment and found the following:

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Reposted by Natalia Nombera Aznaran

Nephrology Journal Club @nephjc.bsky.social · 17/09/2025

Careful flozins, there’s a new multi-tasker in town 😎 #NephJC

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Reposted by Natalia Nombera Aznaran

Brian Rifkin @brianrifkin.bsky.social · 17/09/2025

The GLP1: good for weight, heart, kidney, diabetes, liver (now approved for NASH/MASH). Starting to eclipse the flozins #NephJc

media.tenor.com

the sun is partially obscured by the moon during a solar eclipse

ALT: the sun is partially obscured by the moon during a solar eclipse

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Reposted by Natalia Nombera Aznaran

Nephrology Journal Club @nephjc.bsky.social · 17/09/2025

T1h Next up – Secondary HTN. The guideline provides a thorough table including 15 causes of secondary HTN with indications for additional testing and diagnostic screening tests for each. #NephJC

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Natalia Nombera Aznaran @roxnonna23.bsky.social · 17/09/2025

good list! i think since a pt is diagnosed, is important to always look for end organ damage! #nephjc

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Reposted by Natalia Nombera Aznaran

Nephrology Journal Club @nephjc.bsky.social · 17/09/2025

T1f When nudged, wearers are told to log their BP for 7 days using a BP cuff and then share results with their provider. It is expected over 1 million people with undiagnosed HTN will be notified within the first year!! That’s some real impact…will this be a game changer? #NephJC

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Natalia Nombera Aznaran @roxnonna23.bsky.social · 17/09/2025

still used a lot back in peru, although more focused when there is variability, resistant hypertension, etc #nephjc

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Jordy Cohen @jordybc.bsky.social · 17/09/2025

The guidelines point out literature that home BP seems prognostically similar to ABPM and better for repeatability/longitudinal monitoring. We still use ABPM a lot, but for situations where we need more detailed data (BP lability, new target organ damage, unclear if home BPs are accurate) #nephjc

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Natalia Nombera Aznaran @roxnonna23.bsky.social · 17/09/2025

agree! should be more focused on cv kidney risk reduction, bp goals, and there is inconsistency in the threshold around the world #NephJC

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Natalia Nombera Aznaran @roxnonna23.bsky.social · 17/09/2025

Hi, Natalia Nombera - nephrology research fellow, excited to be here 😀#NephJC

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