Expanding editing scope while reducing byproducts is now possible for prime editing. Here, authors develop reverse prime editing (rPE), a SpCas9-based tool enabling editing in reverse window with high...

Directed evolution is a powerful method to optimize protein fitness. Here, authors develop an active learning workflow using machine learning to more efficiently explore the design space of proteins.

Alt: Otto from the Simpsons is playing a mad riff to the enjoyment of the children

10-11 December 2024, Ghent, Belgium A VIB Tools and Technologies conference

A major goal in synthetic development is to build gene regulatory circuits that control patterning. Here the authors discover that elevated cell density dampens SynNotch signaling, enabling the design...