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Jonas Meisner

@rosemeis.bsky.social

Assistant Professor NNF Center for Basic Metabolic Research University of Copenhagen github.com/Rosemeis

Reposted by Jonas Meisner

Human Genetics and Genomics Advances @hggadvances.bsky.social · 08/01/2026

📣New from @rosemeis.bsky.social 📄Accurate and scalable genome-wide ancestry estimation using haplotype clusters 🖥️ github.com/Rosemeis/hapla 👉 bit.ly/3YuFb3C

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Jonas Meisner @rosemeis.bsky.social · 04/09/2025

Happy to introduce an ancestry estimation submodule in the hapla framework. If you have phased genotype data, unsupervised ancestry estimation has never been faster or more accurate! 🦾 Preprint: www.biorxiv.org/content/10.1... Code: github.com/Rosemeis/hapla

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Reposted by Jonas Meisner

bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 03/09/2025

Accurate and scalable genome-wide ancestry estimation using haplotype clusters www.biorxiv.org/content/10.1101/202…

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Jonas Meisner @rosemeis.bsky.social · 07/01/2025

@naturecomms.bsky.social

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Jonas Meisner @rosemeis.bsky.social · 07/01/2025

Please have a look at the paper and the software! I have just released a new and faster version of *hapla*, and I'm excited about the potential future applications of the inferred haplotype clusters.

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Jonas Meisner @rosemeis.bsky.social · 07/01/2025

We further find that reference-based PRSs computed from large-scale GWAS summary statistics on depression and schizophrenia are highly correlated with estimated principal components in the iPSYCH cohort, thus, indicating residual confounding due to population structure in the GWASs.

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Jonas Meisner @rosemeis.bsky.social · 07/01/2025

We show that we can utilize inferred haplotype clusters to compute more accurate heritability estimates and reference-free polygenic scores compared to standard genotype-based approaches in extensive simulations and the iPSYCH cohort for depression and schizophrenia disorders.

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Jonas Meisner @rosemeis.bsky.social · 07/01/2025

I am excited that our *hapla* framework for fast and scalable haplotype clustering in phased genotype data has been published in Nature Communications! GitHub: github.com/Rosemeis/hapla Paper: www.nature.com/articles/s41...

nature.com

Leveraging haplotype information in heritability estimation and polygenic prediction - Nature Communications

Here the authors develop a framework to leverage haplotype information through clustering for heritability estimation and polygenic prediction. Their approach estimates disease risk more accurately th...

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Jonas Meisner @rosemeis.bsky.social · 13/12/2024

fastmixture is now also officially out in Peer Community Journal! Download it on GitHub and give it a spin: github.com/Rosemeis/fas...

github.com

GitHub - Rosemeis/fastmixture: Software for ancestry estimation in unrelated individuals

Software for ancestry estimation in unrelated individuals - Rosemeis/fastmixture

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Jonas Meisner @rosemeis.bsky.social · 20/11/2024

Delighted that our fastmixture manuscript has now been peer-reviewed and recommended in PCI Evol Biol, now 30x faster than ADMIXTURE! #openscience doi.org/10.24072/pci... BioRxiv: doi.org/10.1101/2024... GitHub: github.com/Rosemeis/fas...

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Reposted by Jonas Meisner

Patrícia Pečnerová @patriciachrzan.bsky.social · 12/11/2024

▪️ Open postdoc position ▪️ 🔎🧬🐘 I'm recruiting a postdoc to work with me on mapping the genomic legacy of the elephant ivory trade in Europe using ancient DNA. Hosted by Lund University 🇸🇪 with Bengt Hansson Please RT! Info and apply here: lu.varbi.com/en/what:job/...

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