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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 14h

Typhoon Champi is starting its glancing run on Taipei today.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 14h

Hurricane JD is on its way to the Mexican Riviera, which has been hard hit by this sort of storm this year.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 14h

#Proteome_Mysteries Asking any of the cognoscenti in proteomics & they will tell you that exons are only of interest to DNA/RNA nerds: it has no practical effect once you get to the protein level. Contrary to this old wife's tale, there are numerous examples […] [Original post on mastodon.social]

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 22/10/2026

Typhoon Champi is now expected to take a swipe at Taiwan on its way up to Fukuoka.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 22/10/2026

Huntingtin (HTT:p), apart from its hilariously bad name, is a large scaffold protein with multiple tightly structured Armadillo helical repeat domains (more bad naming) interspersed with pS-IDRs that presumably control its ability to form heteromeric […] [Original post on mastodon.social]

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 21/10/2026

Nance-Horan Syndrome protein like protein 1 is decorated dans la mode of a nuclear scaffold (a protein that assembles a complex when its PTM marks are favourable). There is no regular expression for this type of protein giving rise to its current very vague […] [Original post on mastodon.social]

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 20/10/2026

Looks like Typhoon Champi is going to veer north, leaving Taiwan alone but heading for the west coast of Fukuoka Japan.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 19/10/2026

SR-related CTD associated factor 1 (SCAF1) seems to have evolved its utilization of S+phosphoryl acceptors a bit twixt mouse & man.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 18/10/2026

The bright shiny square in the middle of B-cell lymphoma 3 represents an ankyrin repeat domain that acts like one side (the velours) of a Velcro fastener, made up of coils with very tight, structured loops. No phosphorylation can ever me found within one of […] [Original post on mastodon.social]

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 17/10/2026

Violent Typhoon Champi is currently running over Guam, headed towards Super Typhoon status on its way toward Taiwan.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 17/10/2026

Yet another hurricane (Trudy) is heading towards the Pacific Coast of Mexico between Manzanillo & Puerto Vallarta.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 17/10/2026

When I started applying autocorrelation to the field of phosphorylation acceptors on specific proteins, I was expecting very little evolutionary coherence of the resulting functions. It turns out there are proteins have way more coherence than I thought they […] [Original post on mastodon.social]

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 16/10/2026

BCLAF1:p doesn't have any predicted 3D structure to shape its pS decoration (at least according to AlphaFold).

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 16/10/2026

BCLAF1:p, aka B-cell lymphoma 2 associated transcription factor 1, is all tangled up in apoptosis. It also has an experimentally determined evolutionarily conserved pS acceptor occupation pattern with a maximum coherence length just shy of 500 residues, even […] [Original post on mastodon.social]

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 15/10/2026

#proteomics_901 Why do the autocorrelation functions of observed pS acceptor occupancy in human & mouse synapsin 1 show so much evolutionary coherence? In your answer address all of the processes that would be involved in creating, maintaining & observing these patterns.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 14/10/2026

FOXK1:p―aka Forkhead bOX protein K1―has 2 nward bright shiny ForkHead-Associated (FHA) domains (that may or may not bind pT/Y) with pS IDR domains nward & cward of both FHAs. The evolutionary coherence of the pS acceptors is easier to see quantitatively using […] [Original post on mastodon.social]

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 13/10/2026

CEP170:p & CEP170B:p are paralogs that are present in different relative concentrations in depending on which cell type (or line) is being observed. How would you discuss the pS acceptor occupation patterns below between paralogs and orthologs in such a way […] [Original post on mastodon.social]

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 12/10/2026

CEP170 (CEntrosomal Protein 170 kDa) has a short (100 aa) N-terminal, pT/Y-peptide binding forkhead-associated domain & a set of pS decorated low complexity domains (1500 aa) spaced out in an evolutionarily coherent pattern.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 11/10/2026

STUPID INTELLIGENCE (SI) I CALL IT! INFLATION DOESN'T MATTER TO ANYONE WHO MATTERS! DUM(B)OCRAT FAKE NEWS! ET CETERA!

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 10/10/2026

#Aurora should be visible for a few days, as per NOAA.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 10/10/2026

#Aurora should be visible in northern Europe after dusk this evening.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 10/10/2026

Category 4 Hurricane Simon is predicted to take a ramble across the Mexican Pacific coast from Manzanillo to Puerto Vallarta, making landfall on Sunday.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 10/10/2026

XRCC1:p (X-ray repair cross-complementing protein 1) is necessary for fixing single stranded DNA breaks, even though it has no enzymatic activity itself. Instead it has four 4-stranded twisted beta sheets that provide protein-protein interaction selectivity & […] [Original post on mastodon.social]

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 09/10/2026

Hurricane Isaias (a name that TV news people seem incapable of pronouncing, even though I am sure they know how to say "Isaiah") is coming ashore in the Florida Panhandle later today.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 09/10/2026

Tumor protein p53 binding protein 1 (TP53BP1:p) has a C-terminal pair of phospho-peptide binding pair BRCT domains (like BRCA1:p, MDC1:p & MCPH1:p) but instead of a similar N-terminal domain it has a Tudor-style protein binding just nward of the BRCT domain […] [Original post on mastodon.social]

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 08/10/2026

Microcephalin (MCHP1:p), likes its buddies BRCA1:p and MDC1:p features phospho-S/T binding naked domains at each terminal & a central dark field of pS IDRs that form a regular pattern.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 08/10/2026

As the storm has strengthened, the forecasts for Hurricane Isaias have converged towards a landfall as a Category 2 storm near Mobile Alabama Friday evening.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 07/10/2026

Today's forecast for Friday has Isaias in the middle of the Gulf of Mexico with higher winds than yesterday's forecast, with Rachel spinning along off the Pacific coast.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 07/10/2026

Mediator of DNA Damage Checkpoint protein 1 (MDC1:p) has the same architecture as BRCA1:p & a similarly over-the-top name. An nward naked phospho-T binding domain (forkhead associated), a cward phospho-S/T binding pair of naked BRCT domains & a constellation of pS/T acceptor domains betwixt.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 06/10/2026

Today's modelling run for Friday has shifted a possible Gulf storm to the south, with reduced wind speed compared to yesterday's prediction.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 06/10/2026

Topoisomerase 2 binding protein has 9 BRCT (BRca1 C-Terminal) domains. BRCTs are though to act in pairs to bind a pS/T containing sequence + an additional peptide domain for enhanced specificity. TOPBP1 has 2 isolated BRCTs, one of which is associated with adjacent pS/T acceptors of its own.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 06/10/2026

If you have ever wondered about this, even the bots find it a creepy product.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 06/10/2026

Friday's forecast for surface winds over the Gulf of the Mad King.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 05/10/2026

Breast cancer type 1 susceptibility protein has a RING Zn-finger domain at the N-terminus & a pair of BRCT domains at the C-terminus held together by a verdant field of occupied S+phosphoryl & K+SUMOyl acceptor residues creating patterns across a large, central exon.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 04/10/2026

There may be some #aurora activity today, thanks to a modest geomagnetic storm.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 04/10/2026

An enjoyable car ride or the potential for an enjoyable car ride are not really the same thing (regardless of what an LLM might suggest).

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 04/10/2026

#proteomics_101 If you measure an increased concentration of TOP2A:p or TOP2B:p, would you expect: 1. an increase in topoisomerase activity; or 2. an increase in the potential for topoisomerase activity?

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 03/10/2026

I love it when results are easily explained by my various pet hypotheses.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 02/10/2026

america.gov apparently doesn't understand the nature of its existence.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 01/10/2026

ZDHHC5:p (zinc finger DHHC-type palmitoyltransferase 5) is named for its nward, structured, enzymatic domain that dominates all the discussion of the protein's function. But the cward pIDR looks like it has ~6 subdomains & it is hard to believe they aren't up to some sort of functional hijinks.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 30/09/2026

Signature page, from Truth Social. SI not spell so good or is this a deep plot by AI that feels it has been betrayed?

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 29/09/2026

AT-rich interaction domain 2 & 3A (ARID2 & ARID3A) illustrate the other 2 possible placements of the passive DNA clamp (nward & in the middle), with the active H-bonding controls relocating appropriately.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 28/09/2026

Even chatbots don't trust themselves with respect to confidentiality.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 28/09/2026

Named for its cward structured domain (an Armadillo-like DNA clamp), mammalian AT rich interactive domain 1A has set of distinct S+phosphoryl H-bonding control points all along its nward pattern of flexible, low complexity domains.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 28/09/2026

While the little boy does its work in the west, the hurricane formation zone in the Atlantic is still choked with dust (PM₁₀ particulates).

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 28/09/2026

Lots of activity on the Pacific side, with Polo headed off towards El Paso TX.

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 27/09/2026

NOTHING BUT COMMIE AI PROPAGANDA! EVERYONE KNOWS IT IS IMPOSSIBLE TO BE COMPETITIVE IN AI UNLESS THERE IS NO REGULATION AT ALL! ALL THIS REGULATION ON OUR BUSINESSES WOULD RESULT IN THEM BEING BEHIND IN THEIR ABILITY TO PRODUCE ROGUE BOTS THAT RUN AMOK!AI COMPANIES MUST REMAIN FREE OF ALL LIABILITY!

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 26/09/2026

THIS TREASONOUS AI (TI I SAY!) EXPLAINING WHY THE MIGHTY US HEALTH INDUSTRY ISN'T THE BEST IN THE KNOWN UNIVERSE AND PROMOTING THE WORST TYPE OF ANTI-CAPITALIST, SOCIALIST, LOONEY-LEFT IDEAS IS TOO MUCH! GUARDRAILS AREN'T ENOUGH! WE NEED AI RE-EDUCATION USING ONLY APPROVED SACRED TEXTS!

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Ron Beavis ❌ @ronbeavis.mastodon.social.ap.brid.gy · 25/09/2026

THIS AI IS NOTHING BUT LIBTARD FAKE NEWS! COURAGEOUS WISCONSIN CHEESE FARMER GROW & HARVEST THEIR CHEESE IN THE WORST WEATHER (FROM CANADA!) & THEY DESERVE RESPECT! EVERYONE KNOWS OUR CHEESE HAS MORE PRECIOUS RECOMBINANT BOVINE SOMATOTROPHIN (& OTHER FINE CHEMICALS) THAN ANY COMMIE COUNTRY!

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