Our “zoo experiment” in Cell Reports @cellpress.bsky.social shows that extracellular cytokine molecules are encoded by surface receptors as quantized signaling units, independent of ligand affinity. A new principle for how cells sense and interpret their environment. www.cell.com/cell-reports...
cell.com
NEMO recruitment at single cytokine-receptor complexes shows quantized dynamics independent of ligand affinity
Kim et al. leverage natural variation in IL-1β affinity across species to show that
while ligand affinity sets activation thresholds, each IL-1 receptor signaling complex
outputs a fixed, quantized bu...
