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Roberto De Filippo @roberto-defilippo.bsky.social · 08/10/2026

thanks, if you press on a paper a side panel appears to see the ranking over time, the title on the side panel brings you directly to the paper on biorxiv 👍

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Reposted by Roberto De Filippo

Alex Kwan @alexkwan.bsky.social · 19/06/2026

We worked hard to revise our #psilocybin & #ketamine snRNA-seq study to make it a resource. Interactive web portal: psilo-seq.kwanlab.org Annotated to @alleninstitute.org’s 16 neuronal and non-neuronal cell types, with updated analyses in preprint: www.biorxiv.org/content/10.1... Check it out!

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Reposted by Roberto De Filippo

Alex Kwan @alexkwan.bsky.social · 05/10/2026

Serotonin biology as a basis for explaining psychedelic drug action - I learned a lot writing this review with @neuroknox.bsky.social www.cell.com/current-biol... We know a good deal about serotonin, which should teach us how psychedelics work. But what’s the same? What’s different? 🤔

cell.com

Serotonin biology as a basis for explaining psychedelic drug action

Knox et al. compare and contrast the biological effects of endogenous serotonin with psychedelics.

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Roberto De Filippo @roberto-defilippo.bsky.social · 04/10/2026

Too many neuro preprints to keep track of, so I made a monthly ranking of the most-read ones on bioRxiv. Not a measure of quality, just what people are reading. Here's the fresh ranking for September: robertodf.github.io/biorxiv-top/

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Ivan Tomic @ivntmc.bsky.social · 10/06/2026

Feeling really proud of this one: a review of Bayesian efficient coding with Máté Lengyel and Paul Bays (@bayslab.org) is now available online in TICS! authors.elsevier.com/a/1nF3i4sIRv...

Screenshot of a Trends in Cognitive Sciences article header. Title: 'Bayesian efficient coding as a theory of perception: progress, controversies, and prospects.' Authors: Ivan Tomić, Máté Lengyel, Paul Bays. Available online 9 June 2026, In Press, Corrected Proof.

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Neuroskeptic @neuroskeptic.bsky.social · 04/09/2026

"Under psilocybin, expected image repetitions aberrantly recruited change-encoding ensembles and shifted cortical population dynamics towards trajectories normally evoked by genuine stimulus changes." www.biorxiv.org/content/10.6... (In mice)

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Nate Heller @nate-h-heller.bsky.social · 26/08/2025

🚨 Limited spots! 👉 🌈🧠 SfN Psychedelic Research Event 🌈🧠 Join us before #SfN2025 (Friday, Nov 14) for a deep dive into cross-species psychedelic neuroscience. Register + speaker profiles: 👉 hopkinspsychedelic.org/sfn2025 Posters, 🎤 panels, 🔑 keynotes,🍸 cocktails + 🥟 bites. #psychedelicresearch

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Reposted by Roberto De Filippo

Torben Ott @torbenottlab.org · 02/09/2026

6/ Now on BioRxiv: Psilocybin collapses visual change detection and drives cortical dynamics toward a state of surprise. t.co/Y8A4Su3rph #Psychedelics #Neuroscience #PsychedelicScience

t.co

https://www.biorxiv.org/content/10.64898/2026.08.21.745777v1

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Torben Ott @torbenottlab.org · 02/09/2026

5/ Our findings point to a previously unrecognized role for SST interneurons in the acute psychedelic state, potentially linking altered surprise signals to visual distortions. A huge thank-you to the entire OpenScope team, especially @jeromelecoq.bsky.social, for making this work possible!

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Torben Ott @torbenottlab.org · 02/09/2026

4/ Unexpectedly, psilocybin's effect were not global or uniform but dependent on the image structure: Only images with long, continuous contours recruited change-encoding neurons that were modulated by psilocybin.

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Torben Ott @torbenottlab.org · 02/09/2026

3/ Surprisingly, despite this oscillation, image id encoding was completely intact! By contrast, this oscillation was closely linked to CHANGE encoding, pushing visual cortex dynamics in SST interneurons towards states usually associated with surprise.

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Torben Ott @torbenottlab.org · 02/09/2026

2/ We found a striking behavioral effect: psilocybin reduced change-detection performance to chance, without causing obvious motor deficits. At the same time, visual stimuli drove a strong 4-Hz oscillation across visual cortex, especially in VISp and SST interneurons.

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Torben Ott @torbenottlab.org · 02/09/2026

#Psilocybin🍄 shifts visual cortex dynamics towards a state of surprise! Thrilled to share our work w/ OpenScope at @alleninstitute.org lead by postdoc @roberto-defilippo.bsky.social. We combined visual change detection w/ Neuropixels recordings in mice to uncover how psilocybin changes circuits 1/

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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 25/08/2026

Psilocybin collapses visual change detection and drives cortical dynamics toward a state of surprise www.biorxiv.org/content/10.64898/20…

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Alex Kwan @alexkwan.bsky.social · 31/08/2026

Two large-scale electrophysiologyical studies of psilocybin's effects in mice, from @alleninstitute.org @torbenott.bsky.social and others. Should be a treasure trove of data for those interested in perceptual effects of #psychedelics www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6...

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