Reposted by Radek Kaczmarek Marcin Czerwinski @czerwinsmarcin.bsky.social · 09/09/2026Erythrocyte Binding Antigen-140 ( PfEBA-140) orthologues in human- and ape-infective Laverania species recognize Neu5Ac and Neu5Gc, but prefer ape-specific Neu5Gc. tinyurl.com/2s36m59n #glycotime #malaria 151
Reposted by Radek Kaczmarek Marcin Czerwinski @czerwinsmarcin.bsky.social · 10/08/2026Fabry disease: a mutation in the GLA gene leading to deficient α-galactosidase A activity, resulting in lysosomal accumulation of globotriaosylceramide (Gb3). Adamantyl-GalCer inhibits the A4GALT activity, causing a decrease in Gb3 production in fibroblasts. tinyurl.com/4cb3wrrz #glycotime 121
Reposted by Radek Kaczmarek Marcin Czerwinski @czerwinsmarcin.bsky.social · 06/08/2026@kmikolajczyk.bsky.social demonstrates small extracellular vesicles derived from Caco-2 and HEK293T cells and functionalized with Gb3 trisaccharide (Galα1→4Galβ1→4Glc) as potent neutralizers of Shiga toxins. #glycotime tinyurl.com/29y8n5yc 152
Reposted by Radek Kaczmarek Marcin Czerwinski @czerwinsmarcin.bsky.social · 04/02/2026Can adeno-associated virus (AAV) gene therapies for hemophilia trigger tumorigenesis? Not really, as @rkaczmarekdr.bsky.social explains... tinyurl.com/3wpfsw3p #hemophilia 022
Reposted by Radek Kaczmarek Marcin Czerwinski @czerwinsmarcin.bsky.social · 05/02/2026Where is coagulation factor VIII (FVIII) produced? After decades of research, the new data show that FVIII comes from liver sinusoidal endothelial cells located in zones 2 and 3 of hepatic lobules in mice and humans, with minimal expression in Zone 1 @rkaczmarekdr.bsky.social tinyurl.com/ydtaar2a 042
Reposted by Radek Kaczmarek Isabella Presch MD MBA @isabellapresch.bsky.social · 25/06/2025Last day starts with an Inspiring presentation @rkaczmarekdr.bsky.social #ISTH2025 #hemophilia #genetherapy #Toleranceinduction Will gene therapy be used for tolerance induction in future? 162
Reposted by Radek Kaczmarek RPTH @rpth.bsky.social · 16/06/2025What percentage of hemophilia patients develop inhibitors? New data from the European Haemophilia Safety Surveillance Inhibitor reveals inhibitor rates of Hemophilia A: 4.2 per 1000 treatment years Hemophilia B: 0.1 per 1000 treatment years Read more here: www.rpthjournal.org/article/S247...rpthjournal.orgInhibitor development in nonsevere hemophilia: data from the European Haemophilia Safety Surveillance (EUHASS) registryInformation on inhibitor development in nonsevere hemophilia and its association with clotting factor concentrate type is limited. 023
Reposted by Radek Kaczmarek Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 07/05/2025Nice #glycotime review that pulls together the emerging story of glycosyltransferase specificity for cellular substrates chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...chemistry-europe.onlinelibrary.wiley.comGlycoproteins, Glycolipids, or Both: Why do Glycosyltransferases Recognize Different Acceptors?Glycosylation is an important post-translational modification catalyzed by glycosyltransferases (GTs), which comprise a large group of enzymes with diversified specificity. Most GTs show high specifi... 14816
Reposted by Radek Kaczmarek Marcin Czerwinski @czerwinsmarcin.bsky.social · 07/05/2025Specificity in glycosylation! Have you ever wondered why some glycosyltransferases recognize glycoproteins, some glycolipids, and some both? Together with @kmikolajczyk.bsky.social and @rkaczmarekdr.bsky.social, we try to answer that complicated question. #glycotime tinyurl.com/5b6kxhp3 02413
Reposted by Radek Kaczmarek Ben Samelson-Jones, MD, PhD @samelsonjones.bsky.social · 30/04/2025It is essential for #genetherapy progress for unsuccessful clinicals trials to be published. We discuss recent study showing no benefit for prophylactic steroids after #AAV for #hemophilia. authors.elsevier.com/a/1k-re5TuFx... w/ @rkaczmarekdr.bsky.socialauthors.elsevier.com 012
Reposted by Radek Kaczmarek ProfMakris @profmakris.bsky.social · 31/03/2025Comprehensive review of gene therapy in #hemophilia accepted for publication by Molecular Therapy. The pre-proof is on line at tinyurl.com/3sb4nuex 043
Reposted by Radek Kaczmarek ProfMakris @profmakris.bsky.social · 03/04/2025Our paper on inhibitor trends is now published in the journal Haemophilia. The number of inhibitors in previously untreated patients has markedly reduced, but it is possible that this is due to delayed exposure to FVIII. tinyurl.com/2mr3t5e3 081
Radek Kaczmarek @rkaczmarekdr.bsky.social · 08/12/2024I was pleased to moderate the session on basic and translational research in coagulation and fibrinolysis with Dr. Carlos Bravo-Perez at #ASH2024 earlier today. Six excellent presentations are now available on the Virtual Platform. 221
