iiinova — where your digital self keeps evolving

Richard Mitchell

@richardmitchell210.bsky.social

18 followers 17 following 0 posts

Posts Replies Media

Reposted by Richard Mitchell

Maria Antoniak @mariaa.bsky.social · 17/07/2025

Is disruption in science decreasing? Maybe not... "Due to a factual plotting mistake, database entries with zero references were omitted in the CD index distributions, hiding a large number of outliers with a maximum CD index of one, while keeping them in the analysis" the classic Seaborn bug 🫣

arxiv.org

Dataset Artefacts are the Hidden Drivers of the Declining Disruptiveness in Science

Park et al. [1] reported a decline in the disruptiveness of scientific and technological knowledge over time. Their main finding is based on the computation of CD indices, a measure of disruption in c...

55210

Reposted by Richard Mitchell

Nature @nature.com · 28/06/2025

Nature research paper: RNA codon expansion via programmable pseudouridine editing and decoding go.nature.com/3G8f3G4

go.nature.com

RNA codon expansion via programmable pseudouridine editing and decoding - Nature

An RNA codon-expansion strategy enables incorporation of non-canonical amino acids into proteins of interest orthogonally to existing methods by inserting pseudouridine codons into specific mRNA transcripts and using an engineered decoder tRNA.

0337

Reposted by Richard Mitchell

Sri Kosuri @srikosuri.bsky.social · 08/02/2025

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

841009846

Reposted by Richard Mitchell

Phoebe Glazer @glazerchemistrylab.bsky.social · 02/12/2024

Congrats to @richardmitchell210.bsky.social for an excellent study leveraging metabolic analysis! This paper shows how photodynamic therapy photosensitizers and photoactivated chemotherapeutics exhibit distinct bioenergetic profiles - now in Chemical Science (a 🧵) pubs.rsc.org/en/content/a...

pubs.rsc.org

Photodynamic therapy photosensitizers and photoactivated chemotherapeutics exhibit distinct bioenergetic profiles to impact ATP metabolism

Energy is essential for all life, and mammalian cells generate and store energy in the form of ATP by mitochondrial (oxidative phosphorylation) and non-mitochondrial (glycolysis) metabolism. These pro...

5328