iiinova — where your digital self keeps evolving

RNA Medicine Group (Oxford) @ribomedicine.bsky.social · 03/09/2026

New research on the challenges of targeting uORFs for TTN up-regulation: Functional analysis of TTN uORFs reveals context-dependent translational regulation. A great collaboration with Prof Hugh Watkins' team #OxfordPaediatrics #IDRMOxford #TTN #uORF #CRISPR #cardiomyopathy doi.org/10.1016/j.om...

010

RNA Medicine Group (Oxford) @ribomedicine.bsky.social · 03/08/2026

New research from my group: treatment timing with peptide-conjugated exon skipping drugs makes a big difference to therapeutic effects in a DMD mouse model. Starting treatment early is more effective. #OxfordPaediatrics #IDRMOxford #DMD #MuscularDystrophy #ExonSkipping #dystrophin

010

RNA Medicine Group (Oxford) @ribomedicine.bsky.social · 07/04/2026

New research from my group using a novel mouse model to better understand spatial dystrophin localisation in dystrophic muscle. onlinelibrary.wiley.com/doi/10.1002/... #OxfordPaediatrics #IDRMOxford #DMD #MuscularDystrophy #MyonuclearDomains #dystrophin

020

RNA Medicine Group (Oxford) @ribomedicine.bsky.social · 14/02/2025

Recent work from my group concerning efforts to target upstream open reading frames (uORFs) using molecular medicine approaches. (More to come soon!)

130

Reposted by RNA Medicine Group (Oxford)

Institute of Developmental & Regenerative Medicine @idrm.ox.ac.uk · 11/12/2024

📢 Huge News! 📢 The MRC has launched two centres of research excellence to transform gene therapies: IDRM’s Paul Riley will co-direct the MRC/BHF CoRE in Advanced Cardiac Therapies & Stephan Sanders will direct the MRC CoRE in Therapeutic Genomics. Read more: lnkd.in/g-3CmAsP #GeneTherapies

0115

RNA Medicine Group (Oxford) @ribomedicine.bsky.social · 19/11/2024

A brief commentary that I wrote for Methods & Clinical Development on exon skipping therapy for DMD patients with exon 2 duplications (from the Flanigan lab) www.sciencedirect.com/science/arti...

sciencedirect.com

Long-term dystrophin restoration supports development of splice correction therapy for DMD patients with exon 2 duplications

100

RNA Medicine Group (Oxford) @ribomedicine.bsky.social · 19/11/2024

A talk that I gave for the EVClub on recent work from my group on the subject of extracellular vesicles and their role in the regulation of myogenic differentiation. www.youtube.com/watch?v=CMxr...

youtube.com

Tom Roberts: Functional consequences of EV dose and co-isolates

YouTube video by EVClub: Extracellular Vesicle Club

000

RNA Medicine Group (Oxford) @ribomedicine.bsky.social · 19/11/2024

Hi BlueSky! I'm going to move some of my old tweets over here #Xodus

020