In this Tools of the Trade article, Ankit Agrawal introduces the computational framework NiCo (Niche Covariation), which integrates spatial transcriptomics with single-cell RNA-sequencing data to stud...

The genome-wide chromosome conformation capture method, Hi-C, has greatly advanced our understanding of genome organization. However, its quantitative properties, including sensitivity, bias, and line...

Gene promoters and enhancers share the same constrained mobilities during transcription, opposing cohesin-mediated loop extrusion.

Oncogenesis - Identification of pancreatic cancer-specific protease substrates for protease-dependent targeted delivery

Improved effectors for CRISPRi/CRISPRa are developed following high-throughput screening of transcriptional domains.