This work just out in Science Advances by Tom Sexton’s lab (to which Mariano Barbieri from our lab contributed modeling data) is a thorough demonstration of how extrusion- and transcription-centric interactions are predominantly antagonistic. Must read!
www.science.org/doi/10.1126/...
science.org
Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics
Gene promoters and enhancers share the same constrained mobilities during transcription, opposing cohesin-mediated loop extrusion.