iiinova — where your digital self keeps evolving

👤 Creator: Donghai Chen, Yayin Luo, Yuhao Zhang, Wenlong Zhang, Zhuqing Yuan, Zhixuan He, Haochong Xie, Meijun Qu, Tong Lin, Jiawei Li, Qingwei Song, Yanwei Miao, Zhe Wang, Jian Jiang, Renwang Pu

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편두통 연구알리미 @research.migraine.kr · 6h

🆔 PMID: 42861105 📄 PMC: PMC13654134 🔗 DOI: 10.21037/qims-2026-1113

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편두통 연구알리미 @research.migraine.kr · 6h

for multiple comparisons, and the cross-sectional study design, these results should be validated in larger longitudinal cohorts. (🧵 14/14)

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편두통 연구알리미 @research.migraine.kr · 6h

the right superior temporal gyrus, which was not detected by VBM. Given the exploratory nature of these findings, the lack of significant brain-clinical correlations after correction (🧵 13/14)

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편두통 연구알리미 @research.migraine.kr · 6h

CONCLUSIONS: Patients with MwoA exhibited widespread GMV reductions across brain regions involved in emotional and pain-related processing. In addition, patients with higher depressive symptom levels showed a distinct cortical morphological feature characterized by lower LGI in (🧵 12/14)

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편두통 연구알리미 @research.migraine.kr · 6h

Exploratory partial correlation analyses indicated that no imaging metric was significantly associated with HAMD-17 scores or other clinical measures after FDR correction (all q＞0.05). (🧵 11/14)

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편두통 연구알리미 @research.migraine.kr · 6h

in the MwoA-HS group showed significantly lower LGI in the right superior temporal gyrus than those in the MwoA-LS group (cluster size =73; FDR-corrected q=0.019). (🧵 10/14)

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편두통 연구알리미 @research.migraine.kr · 6h

(two clusters, size =218, q=0.046 and size =177, q=0.046), and right angular gyrus extending into the middle occipital gyrus and precuneus (cluster size =427; q=0.036). No significant between-group differences were observed in any SBM measure. In the subgroup analysis, patients (🧵 9/14)

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편두통 연구알리미 @research.migraine.kr · 6h

RESULTS: Compared with HC, patients with MwoA exhibited significant reductions in GMV in the left amygdala (cluster size =305; FDR-corrected q=0.046), left parahippocampal gyrus (cluster size =273; q=0.036), left lingual gyrus (🧵 8/14)

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편두통 연구알리미 @research.migraine.kr · 6h

Statistical significance was defined using a voxel-/vertex-level threshold of P＜0.001 (uncorrected), followed by cluster-level false discovery rate (FDR) correction at q＜0.05. (🧵 7/14)

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편두통 연구알리미 @research.migraine.kr · 6h

using two-sample t-tests within a general linear model framework, with sex, education, total intracranial volume (TIV) (for VBM), mean CT (for SBM), and Hamilton Anxiety Rating Scale (HAMA) scores included as covariates. (🧵 6/14)

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편두통 연구알리미 @research.migraine.kr · 6h

and 40 HC were included. High-resolution T1-weighted magnetic resonance imaging (MRI) data were processed using CAT12 to derive GMV, cortical thickness (CT), local gyrification index (LGI), sulcal depth (SD), and fractal dimension (FD). Between-group comparisons were conducted (🧵 5/14)

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편두통 연구알리미 @research.migraine.kr · 6h

{38 with lower depressive symptoms [MwoA-LS, 17-item Hamilton Depression Rating Scale (HAMD-17) ＜8] and 29 with higher depressive symptoms (MwoA-HS, HAMD-17 ≥8)} (🧵 4/14)

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편두통 연구알리미 @research.migraine.kr · 6h

subgroups stratified by depressive symptom severity, thereby identifying potential structural correlates of depressive symptoms in this population. METHODS: A total of 67 patients with MwoA (🧵 3/14)

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편두통 연구알리미 @research.migraine.kr · 6h

This study integrated voxel-based morphometry (VBM) and surface-based morphometry (SBM) to compare gray matter volume (GMV) and cortical morphology between patients with MwoA and healthy controls (HC) and to further determine whether structural brain alterations vary across MwoA (🧵 2/14)

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편두통 연구알리미 @research.migraine.kr · 6h

BACKGROUND: Migraine without aura (MwoA) frequently co-occurs with depressive symptoms, yet the neurobiological mechanisms underlying this comorbidity remain insufficiently characterized. (🧵 1/14)

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편두통 연구알리미 @research.migraine.kr · 6h

👤 Creator: Chisato Fujimoto, Naoko Ogata, Kento Koda, Kentaro Ichijo, Mineko Oka, Makoto Kinoshita, Kenji Kondo

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편두통 연구알리미 @research.migraine.kr · 6h

🆔 PMID: 42860634 🔗 DOI: 10.1111/coa.70158

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편두통 연구알리미 @research.migraine.kr · 6h

associations. CONCLUSION: VM patients are more likely to report depressive symptoms than PVM patients, suggesting an association between VM pathophysiology and depressive symptoms. (🧵 7/7)

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편두통 연구알리미 @research.migraine.kr · 6h

There was no significant association between the VM diagnostic category and STAI-1 or STAI-2 scores (p = 0.542 and 0.367; post hoc power = 0.10 and 0.23), suggesting that limited statistical power may have affected detection of anxiety (🧵 6/7)

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편두통 연구알리미 @research.migraine.kr · 6h

RESULTS: The VM diagnostic category was significantly associated with SDS scores, with VM patients showing higher scores than PVM patients (p = 0.0095; post hoc power = 0.92). (🧵 5/7)

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편두통 연구알리미 @research.migraine.kr · 6h

Thirty-four VM patients and 13 PVM patients were included. Multiple regression analyses were performed to see whether the subjects' age, sex or the VM diagnostic category (VM vs. PVM) had an association with SDS, STAI-1 and STAI-2 scores. (🧵 4/7)

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편두통 연구알리미 @research.migraine.kr · 6h

the criteria for PVM. METHODS: We reviewed the medical records of 1736 consecutive patients seen at our clinic between March 2018, when routine measurement of Self-rating Depression Scale (SDS) and State-Trait Anxiety Inventory (STAI) began, and December 2024. (🧵 3/7)

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편두통 연구알리미 @research.migraine.kr · 6h

This study aimed to investigate this association by comparing patients with VM and probable VM (PVM), based on the hypothesis that patients fulfilling the complete diagnostic criteria for VM more closely represent the core clinical phenotype of the disorder than those fulfilling (🧵 2/7)

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편두통 연구알리미 @research.migraine.kr · 6h

INTRODUCTION: It has been previously reported that patients with vestibular migraine (VM) are more prone to anxiety and depressive symptoms. However, the association between the pathophysiology of VM and anxiety and depressive symptoms is still unclear. (🧵 1/7)

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편두통 연구알리미 @research.migraine.kr · 6h

Depressive and Anxiety Symptoms in Vestibular Migraine and Probable Vestibular Migraine ▶️ Read Full Paper 📚 Source: Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 👤 Creator: Chisato Fujimoto et al. 📅

pubmed.ncbi.nlm.nih.gov

Depressive and Anxiety Symptoms in Vestibular Migraine and Probable Vestibular Migraine

CONCLUSION: VM patients are more likely to report depressive symptoms than PVM patients, suggesting an association between VM pathophysiology and depressive symptoms.

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

👤 Creator: Young-Eun Gil, Mi Ji Lee

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

🆔 PMID: 42856068 🔗 DOI: 10.1111/head.70208

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

migraine burden and clinical characteristics. These findings underscore the importance of individualized clinical counseling over uniform exercise recommendations in migraine management. (🧵 10/10)

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

Headache improvement during exercise was associated with older age, CM (vs. LFEM, aOR 1.42, 95% CI 1.09-1.86), and self-reported anxiety (aOR 1.58, 95% CI 1.12-2.25). CONCLUSIONS: Perceived headache responses to exercise are highly heterogeneous and vary according to (🧵 9/10)

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

with greater odds of provocation. Younger age, higher migraine burden (HFEM, CM), the presence of allodynia (Allodynia Symptom Checklist-12 item ≥ 3), and self-reported anxiety were independently associated with exercise-related headache provocation. (🧵 8/10)

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

The perceived likelihood of exercise-related headache provocation was greater among patients with more frequent headaches; compared with LFEM, both HFEM (adjusted odds ratio [aOR] 1.71, 95% confidence interval [CI] 1.19-2.46) and CM (aOR 2.50, 95% CI 1.88-3.31) were associated (🧵 7/10)

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

of 1828 patients responded to the survey. Among them, 883 (48.3%) reported no association between exercise and headache, 443 (24.2%) reported provocation, 457 (25.0%) reported headache improvement during exercise, and 45 (2.5%) reported headache worsening without exercise. (🧵 6/10)

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

Self-reported headache responses to exercise were further analyzed according to monthly headache days (low-frequency episodic migraine [LFEM]: 0-7 days/month, high-frequency episodic migraine [HFEM]: 8-14 days/month, and chronic migraine [CM]: ≥15 days/month). RESULTS: A total (🧵 5/10)

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

Based on the responses to a structured questionnaire, patients were classified into four mutually exclusive groups: no-association, provocation, headache-improvement-during-exercise, and headache-worsening-without exercise. (🧵 4/10)

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

METHODS: We conducted a cross-sectional survey of patients with migraine who visited the headache clinic of a university hospital in Seoul, South Korea, between October 2022 and December 2024. (🧵 3/10)

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

BACKGROUND: Regular exercise is often recommended for patients with migraine; however, it can also trigger migraine attacks. This complex effect makes it challenging for both patients and clinicians to determine the appropriate role of exercise in migraine management. (🧵 2/10)

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

OBJECTIVE: To characterize patient-perceived headache responses to exercise in migraine and to identify associated clinical factors using a large-scale registry. (🧵 1/10)

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

👤 Creator: Elizabeth Leroux, Dawn C Buse, Michel Lanteri-Minet, Fumihiko Sakai, Manjit Matharu, Zaza Katsarava, Kristina M Fanning, Karen Carr, Nicole Naccara, Janette Contreras-De Lama, Richard B Lipton

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

🆔 PMID: 42856050 🔗 DOI: 10.1111/head.70241

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

These results support the need for better treatment optimization. (🧵 14/14)

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

CONCLUSION: Among CaMEO-I respondents with migraine, opioid users were more likely to have moderate or severe disability and patient-reported cognitive impairment, although causality cannot be determined from cross-sectional analyses. (🧵 13/14)

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

(49.3% [1462/2965] vs. 20.3% [1960/9647]), emergency department/urgent care visits (14.4% [426/2965] vs. 3.5% [336/9647]), and hospital stays (19.4% [571/2949] vs. 4.9% [472/9617]) for headache during the past 6 months (p ＜ 0.001). (🧵 12/14)

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

Opioid users had higher median (interquartile range [IQR]) patient-reported cognitive impairment scores on the MCIQ than nonusers (61.1 [44.4, 83.3] vs. 50.0 [33.3, 72.2], p ＜ 0.001). Higher proportions of opioid users than nonusers had one or more doctor visits (🧵 11/14)

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

. Poorer treatment optimization was associated with significantly greater odds of moderate to severe disability (p ＜ 0.001), and opioid use was associated with increased disability across all countries (p ＜ 0.001). (🧵 10/14)

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

(very poor [64.7% {123/190} vs. 49.7% {373/750}], poor [62.6% {1110/1772} vs. 46.5% {2208/4747}], moderate [51.0% {338/663} vs. 35.6% {824/2314}], maximum [38.8% {132/340} vs. 19.9% {366/1836}]) (🧵 9/14)

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

Rates of opioid use for migraine ranged from 6.3% (127/2023) in Japan to 37.2% (814/2186) in France. The proportions of respondents with moderate to severe disability were higher among opioid users than nonusers at each level of treatment optimization on the mTOQ (🧵 8/14)

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편두통 연구알리미 @research.migraine.kr · 10/10/2026

RESULTS: A total of 12,612 respondents with migraine who used prescription or over-the-counter medication for acute treatment of headaches (mean age, 41.8 years; 71.3% female) were included; 23.5% (2965/12,612) used opioids. (🧵 7/14)

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