CONCLUSIONS: Patients withMwoA exhibited widespread GMV reductions across brain regions involved in emotional and pain-related processing. In addition, patients with higher depressive symptom levels showed a distinct cortical morphological feature characterized by lower LGI in...

CONCLUSION: VM patients are more likely to report depressive symptoms than PVM patients, suggesting an association between VM pathophysiology and depressive symptoms.

CONCLUSIONS: Perceived headache responses to exercise are highly heterogeneous and vary according to migraine burden and clinical characteristics. These findings underscore the importance of individualized clinical counseling over uniform exercise recommendations in migraine m...

CONCLUSION: Among CaMEO-I respondents with migraine, opioid users were more likely to have moderate or severe disability and patient-reported cognitive impairment, although causality cannot be determined from cross-sectional analyses. These results support the need for better ...

CONCLUSIONS: The study finds that analysis of migraine discourse across the 5 Gulf countries reveals active engagement by patients and HCPs in migraine-related discussions on various social media platforms. However, many rely on self-management and alternative medicine instead...

Migraine and epilepsy frequently coexist, but evidence on the safety of calcitonin gene-related peptide (CGRP)-targeting therapies in people with epilepsy is lacking. We evaluated long-term migraine and epilepsy outcomes in a real-world multicenter retrospective cohort of adul...

Migraine and obesity are highly prevalent, chronic conditions that frequently coexist, presenting a significant clinical and therapeutic challenge. Their relationship is multifactorial and bidirectional, albeit with more consistent evidence supporting obesity as a contributor ...

CONCLUSION: Statins might be considered for migraine treatment and prevention in individuals with chronic migraine, aura, hyperlipidemia, hypertension, a family history of cardiovascular disease, or other cardiovascular risk factors. We hope that the present article will encou...

No abstract

CONCLUSION: Topiramate and amitriptyline both were effective in decreasing headache frequency and headache-related disability among chronic migraine patients. Topiramate was slightly more effective and better tolerated than amitriptyline.

CONCLUSION: This study highlights how migraine differentially affects women and men. Subtle variations by sex in factors provocative of a migraine attack and reasons for rimegepant use were observed. Regardless of sex, rimegepant has potential for STP of migraine. Women and me...

CONCLUSION: NC showed analgesic effect, and p38β MAPK was most likely to be the targets against vasospastic cold-coagulation migraine.

No abstract

CONCLUSION: This meta-analysis suggests migraine is associated with a significantly increased risk of glaucoma. While the association persisted directionally after adjusting for potential publication bias, its magnitude varied by data source, diagnostic method, and population ...

Migraine is the most prevalent neurological disorder presenting to primary and secondary care. It can be severely disabling. Its effective management improves quality of life of our patients. Over the last few decades, new acute and preventive treatment options have arrived th...

Migraine is a chronic neurovascular disorder characterised by recurrent attacks of moderate-to-severe head pain, accompanied by transient but disabling symptoms such as aura, nausea, vomiting, phonophobia, and photophobia, reflecting the involvement of multiple systems. Migrai...

CONCLUSIONS: PID is associated with significantly elevated long-term risks of both migraine and tension headache. These findings highlight the potential neurological sequelae of systemic inflammation and central sensitization triggered by PID.

PurposeMotion sickness (MS), visually induced motion sickness (VIMS), hyperemesis gravidarum (HG), and migraine share a spectrum of symptoms, including nausea, vomiting, dizziness, and heightened motion sensitivity. These commonalities suggest a potential shared neurophysiolog...

CONCLUSION: In Kawasaki, awareness and use of new migraine therapies remain limited, especially among nonspecialists. Specialty independently influenced the prescription of anti-CGRP monoclonal antibodies but not triptans, highlighting the need for enhanced education and colla...

Gallardo and colleagues reported higher serum neurofilament light (sNf-L), greater susceptibility-weighted imaging signal in the left rostral anterior cingulate cortex, and lower fractional anisotropy in the right cuneus in patients with high-frequency migraine. Their prospect...

CONCLUSION: In selected patients with treatment-resistant CM, triple preventive therapy was associated with delayed but clinically meaningful reductions in migraine burden and disability. No major tolerability issues were observed, although the small sample size precludes conc...

CONCLUSION: Rimegepant was effective and safe for the acute treatment of migraine. Co-primary endpoints at 2 h post dose were not met in patients that are HL; exploratory analyses suggest that patients that are HL may experience a 1-2 h delayed response to rimegepant, with a g...

To investigate the protective effects of ligustrazine (Lig) against nitroglycerin (NTG)-induced migraine and explore its underlying mechanisms, with a particular focus on mitochondrial energy metabolism and the coordinated regulation of protease-activated receptor 2 (PAR2), cy...

CONCLUSION: Both patient-preference cohorts showed within-group improvement over six months. Preference-based allocation, baseline phenotype differences, incomplete follow-up and the sensitivity of the between-group comparisons to multiplicity and covariate adjustment prevent ...

CONCLUSIONS: Temporally organized cerebral perfusion changes were observed during and after Japanese-style acupuncture in both healthy controls and patients with episodic migraine. Compared with healthy controls, patients with episodic migraine exhibited cerebral perfusion cha...

CONCLUSIONS: Temporally organized cerebral perfusion changes were observed during and after Japanese-style acupuncture in both healthy controls and patients with episodic migraine. Compared with healthy controls, patients with episodic migraine exhibited cerebral perfusion cha...

CONCLUSION: This protocol describes a randomized, single-blind trial that will evaluate the efficacy of acupuncture for acute migraine and explore plasma protein biomarkers potentially associated with short-term acupuncture response. The exploratory model is intended to assess...

CONCLUSION: From the Chinese health system perspective, erenumab as preventive treatment provides modest health gains for adults with chronic migraine but is unlikely to be cost-effective at its current price.

CONCLUSION: This protocol describes a randomized, single-blind trial that will evaluate the efficacy of acupuncture for acute migraine and explore plasma protein biomarkers potentially associated with short-term acupuncture response. The exploratory model is intended to assess...

CONCLUSION: From the Chinese health system perspective, erenumab as preventive treatment provides modest health gains for adults with chronic migraine but is unlikely to be cost-effective at its current price.

CONCLUSION: Higher overall diet quality was associated with lower migraine burden and caregiver burden in children with migraine. These findings support the relevance of overall dietary assessment, while prospective studies are needed to clarify temporal and causal relationshi...

CONCLUSION: Higher VSS-C total symptom burden was associated with larger anterior-superior hypothalamic volume in women with migraine. This result identifies a subregional target for prospective replication with component-level symptom assessment and formal vestibular phenotyp...

CONCLUSIONS: In appropriately selected patients with chronic intractable migraine with focal frontal trigger sites, positive diagnostic nerve block, and refractory disease, supraorbital and supratrochlear nerve decompression can produce durable and sometimes complete relief of...

CONCLUSIONS: NIBS, particularly rTMS, may be effective in reducing headache severity and disability in non-migraine primary headache disorders. However, further high-quality, large-scale studies are needed to establish its role in routine clinical practice.

CONCLUSIONS: We report a novel homozygous TRPM6 frameshift variant in a patient with profound hypomagnesemia who experienced a severe migraine attack initially unresponsive to treatment. The rapid response to IV magnesium is consistent with a possible contribution of magnesium...

CONCLUSIONS: The study concludes that administering 200 U of OnaBT-A, significantly decreases the frequency and duration of headaches when compared to 155 U. It recommends considering this dosage for patients who do not accomplish adequate relief with 155 U of OnaBT-A. The pro...

CONCLUSIONS: The study concludes that administering 200 U of OnaBT-A, significantly decreases the frequency and duration of headaches when compared to 155 U. It recommends considering this dosage for patients who do not accomplish adequate relief with 155 U of OnaBT-A. The pro...

CONCLUSION: The anti-migraine effect of XZQF is a synergistic result in the forms of "multi-component -target -pathway" regulation. Mechanistically, by activating 5-HT(1)B expression and suppressing the TPH2/CGRP axis, as well as inhibiting the overactivation of PI3K and cAMP ...

CONCLUSION: In some patients unsuitable for triptans, rimegepant can provide rapid onset (within 1-2 h) of migraine symptom improvement. Improvements may be observed up to 48 h. Rimegepant may be appropriate when triptans are not suitable, particularly in individuals who faile...

CONCLUSION: In this retrospective comparative observational study, ultrasound-guided continuous radiofrequency of the C2 dorsal root ganglion was associated with greater improvements in headache symptoms, psychological status, and functional disability compared with oral zolmi...

CONCLUSIONS: CRCR provided therapeutic benefits against chronic migraine through regulating the MAPK/ERK/CREB pathway. LIG represents a higher content in the blood and brain of migraine rats and remarkably suppresses MAPK/ERK/CREB pathway. Targeting MAPK mediated neuroinflamma...

OBJECTIVE: To describe suspected acute acrylamide toxicosis in dogs following ingestion of consumer polyacrylamide-based hydrogel migraine caps, eye masks, and wraps, and to quantify acrylamide monomer concentrations in associated products.

CONCLUSION: This case underscores the importance of recognizing HM as a stroke mimic. Integration of the clinical context with MRI findings - particularly the absence of ADC restriction - can help differentiate HM from acute ischemic stroke and guide appropriate clinical manag...

CONCLUSION: This case underscores the importance of recognizing HM as a stroke mimic. Integration of the clinical context with MRI findings - particularly the absence of ADC restriction - can help differentiate HM from acute ischemic stroke and guide appropriate clinical manag...

CONCLUSION: This case underscores the importance of recognizing HM as a stroke mimic. Integration of the clinical context with MRI findings - particularly the absence of ADC restriction - can help differentiate HM from acute ischemic stroke and guide appropriate clinical manag...

BACKGROUND: Despite the recent therapeutic advances, approximately one-third of patients with chronic migraine fail to achieve clinically meaningful benefit, and existing oral preventive therapies remain limited by tolerability and off-target effects. There is, therefore, a pr...

Migraine remains under-recognised despite its substantial global burden. This Correspondence presents Migraine 1-2-3-4-5 as a candidate communication aid for adults aged 18 years or older with recurrent headache. It reorganises selected positive clinical features of migraine w...

CONCLUSIONS: This feasibility trial demonstrated that a pediatric nutrition-based migraine intervention integrating dried blood spot biomarker collection, repeated dietary recalls, validated patient-reported outcomes, and structured remote follow-up is feasible and acceptable ...

Meniere's disease and vestibular migraine are common episodic vestibular syndromes whose overlapping vertigo, auditory, and migraine-associated features can complicate differential diagnosis. In this narrative review, we compared the diagnostic criteria, symptom patterns, path...

CONCLUSION: Following rimegepant 75-mg treatment initiation, it is expected that 50% of patients will experience first ≥ 50% reduction in WMDs by week 2 and sustained reduction by week 3. Graphical abstract available for this article.