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Reproductive BioMedicine Online

@rbmonline.bsky.social
448 followers 334 following 756 posts

An international journal dedicated to biomedical research on human conception and the welfare of the human embryo. www.linktr.ee/rbmo #ReproMed #IVF #Embryology #Fertility

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Reproductive BioMedicine Online @rbmonline.bsky.social · 3h
Evidence on hypertensive disorders of pregnancy remains inconclusive, due to the limitations in available RCTs. Adequately powered, multicenter RCTs are needed to determine clinically meaningful differences exist in any outcomes, and guide evidence-based protocol selection. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 9h
This new study led by Sergi Novo, compares the laboratory performance of two commercially available denuding preparations, Cumulase® and Hyase, under controlled sibling-oocyte conditions, providing a robust assessment of hyaluronidase type in routine ICSI practice. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 08/10/2026
This new Countercurrent argues that IVF has concentrated innovation in the embryo laboratory while neglecting to identify the major measure of patients at risk of dropout. The paper presents a four-step agenda to measure this as an outcome, with existing clinic data. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 08/10/2026
Day 7 euploid blastocyst transfer is associated with a moderately lower live birth rate than day 5 or day 6 transfer, but the outcomes are still clinically acceptable, and importantly, no increase in maternal or neonatal risks was observed. doi.org/10.1016/j.rb... #Periconception
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Reproductive BioMedicine Online @rbmonline.bsky.social · 07/10/2026
These findings highlight the heterogeneity of treatment effects in ART and support the consideration of individual-specific factors, including the POSEIDON criteria, when choosing the embryo transfer strategy. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 07/10/2026
Overnight hypothermic transport of ovarian tissue appears feasible within a centralized cryobanking model in routine practice. No differences were detected between ONT (+) and ONT (-) cohorts regarding endocrine activity restoration, clinical pregnancy, or live birth. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 06/10/2026
Unlike prior research which predominantly treated age as a categorical variable, this study modelled age as a continuous variable, and confirmed that endometrial aging has a significant impact on pregnancy outcomes, with 33 years of age being a critical threshold. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 05/10/2026
This new paper investigated whether scores from the MAGENTA™ platform, associated with embryo development and cumulative outcomes after freeze-all ICSI, add information beyond the embryo Known Implantation Data score (KIDScore). doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 02/10/2026
This new study supports the use of random start NPPOS with oral micronized progesterone as an effective, flexible and patient-friendly alternative to the conventional GnRH-antagonist protocol for elective freeze-all cycles. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 02/10/2026
This study from Takahashi Women’s Clinic, Chiba, provides comprehensive evidence supporting that simplified warming protocols do not compromise outcomes for either cleavage-stage embryos or blastocysts. doi.org/10.1016/j.rb... #ClinicalEmbryology #Cryopreservation
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Reproductive BioMedicine Online @rbmonline.bsky.social · 01/10/2026
This systematic review examines the relationship between chronic endometritis and RIF, with specific attention to prevalence, diagnostic approaches and therapeutic strategies, and their impact on clinical pregnancy and live birth rates. Read the full Review for free doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 01/10/2026
It's the first Thursday of the month, which means a new issue of RBMO Insights is out! This month we start a new series demystifying journal jargon, and our regular article highlights, section profile, and Talking Points. Enjoy! bit.ly/insights53
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Reproductive BioMedicine Online @rbmonline.bsky.social · 30/09/2026
Many women recover spontaneous ovarian function and fertility after OTC, while for those who do not, subsequent OTT offers a possibility of restoring both menstruation and fertility, confirming OTC/OTT as an effective long-term strategy for fertility preservation. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 29/09/2026
Prof Esteves on the practical diagnostic recommendations for semen analysis in the WHO Guideline for the prevention, diagnosis and treatment of infertility #RBMOlive #Andrology #SpermStandards #SemenAnalysis #WHOguidelines
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Reproductive BioMedicine Online @rbmonline.bsky.social · 29/09/2026
He recently published a Commentary in RBMO, with Allan Pacey and Christopher De Jonge that adds greater insights: Paternal reproductive health in focus: new World Health Organization infertility guideline interpreted through a biological and clinical lens doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 29/09/2026
Prof Esteves discusses the WHO Guideline for the prevention, diagnosis and treatment of infertility: summary of recommendations Full guidelines are here: iris.who.int/items/aee659...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 29/09/2026
Prof Martins da Silva discussing the extended carrier screening - intended to identify a range of genetic conditions, specifically recessive and X-linked disorders, but due to uncertain or poorly understood genetic findings, ECS is not currently recommended. #RBMOlive #UKDonorGuidelines
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Reproductive BioMedicine Online @rbmonline.bsky.social · 29/09/2026
Prof Martins da Silva talking through the screening guidance for bacterial infections for sperm, egg and embryo donors from the UK Guidelines for the Medical and Laboratory Procurement and Use of Sperm, Egg and Embryo Donors (2025) Access the paper open access for free doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 29/09/2026
Fantastic to see so much interest in male infertility and andrology tonight. it's not too late to join us, if you are able: us02web.zoom.us/webinar/regi... Follow for more posts from the evening as it happens! #RBMOlive #Andrology #SpermStandards
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Reproductive BioMedicine Online @rbmonline.bsky.social · 29/09/2026
We are LIVE! with International IVF Initiative for our 17th webinar. Nico Garrido and Sandro Esteves welcome a huge international audience to our session tonight – from USA, Spain, Brazil, Jordan, Egypt, Canada, Jamaica, Nigeria, Madagascar, India, Turkey, Iraq, Greece, UK….and many more!
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Reproductive BioMedicine Online @rbmonline.bsky.social · 29/09/2026
This review examines how automation may be integrated into IVF laboratories through a set of conceptual distinctions, with the aim of improving consistency and laboratory capacity, while preserving clinical responsibility, trust in automation, and professional satisfaction. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 28/09/2026
This new study demonstrates that continuous dienogest administration led to a significant decrease in endometrioma diameter and volume over follow-up, with the highest reduction observed within the first 6 months of treatment. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 25/09/2026
For female same-sex couples, IUI alone had a similar success rate to IUI with ovarian stimulation. In women aged <35 years, >50% are likely to achieve pregnancy after six IUI cycles, but in those aged ≥35 years, alternative fertility treatment should be expedited. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 25/09/2026
The results in this new study suggest that congenital uterine anomalies (CUA) may be associated with a less favourable implantation environment and early gestational adaptation, with the most consistent adverse findings observed in septate uterus. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 24/09/2026
This review synthesizes over 20 years of research, through January 2025, into endometrial scratch techniques, examining whether methodological variations explain conflicting outcomes and assessing the clinical significance of reported benefits. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 24/09/2026
This new paper from an international group of authors is one of the most comprehensive investigations demonstrating the impact of a systematic internal audit system on embryological and clinical outcomes in IVF laboratories. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 23/09/2026
Join us for next live webinar next week, Tuesday 29th, with Nico Garrido, Sandro Esteves, Sarah Martins da Silva and Ahmad Metwalley discussing on the latest advances and guidance in sperm standards and male infertility management Follow the link for full details sh1.sendinblue.com/3g3ej2855z9p...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 23/09/2026
The results presented by Laura Melado and co-authors in this paper may provide valuable complementary information on follicular sensitivity during ovarian stimulation. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 23/09/2026
This paper details how microchimerism can be detected in menstrual blood, with data showing its presence in all groups of women, irrespective of group or parity. Published open access, the full paper is available from the Periconception section of our November issue, now: doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 22/09/2026
This new Commentary strives towards collaboration between neurologists, endocrinologists and immunologists to ensure reproduction in MS would no longer be only a matter of protecting fertility, but an opportunity to better understand the biology of the disease itself. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 22/09/2026
This study demonstrates the success of using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) combined with machine learning, to accurately classify embryos by ploidy status using spent embryo culture media (SECM). doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 21/09/2026
This new Review article provides an updated overview of the effects of chemotherapy on the ovary, and summarize current and emerging gonadoprotective strategies doi.org/10.1016/j.rb... Chemotherapy #Fertility
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Reproductive BioMedicine Online @rbmonline.bsky.social · 21/09/2026
This new paper presents the first US study to report on the pregnancy outcomes from fast vitrification protocols in the setting of both standard warming and fast warming protocols - adding to the literature supporting the adoption of fast vitrification and warming protocols. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 18/09/2026
This is the first study to systematically detail the regulatory role and molecular mechanism of pyruvate carboxylase in the progression of endometriosis, indicating a role as both a biomarker and a potential therapeutic target for endometriosis. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 18/09/2026
In women with infertility and in those who have experienced RPL or RIF, diffuse adenomyosis involving the inner myometrial layer was associated with a significantly higher prevalence of chronic endometritis in this cohort. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 17/09/2026
The session will conclude with our regular panel discussion session giving you a chance to put your questions to our speakers. Registration is free and open now! Join us and hundreds of live attendees for what we are sure will be a fascinating and useful session. bit.ly/RBMOlive17 6/6
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Reproductive BioMedicine Online @rbmonline.bsky.social · 17/09/2026
and Professor Sandro Esteves will give his perspectives on the WHO infertility guidelines, highlighting the need to move toward equitable global standards in the management of male infertility. doi.org/10.1016/j.rb... 5/6
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Reproductive BioMedicine Online @rbmonline.bsky.social · 17/09/2026
Professor Sarah Martins da Silva will discuss the important practical applications in the recently published ‘UK Guidelines for the Medical and Laboratory Procurement and Use of Sperm, Egg and Embryo Donors, of which she was the lead author. doi.org/10.1016/j.rb... 4/6
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Reproductive BioMedicine Online @rbmonline.bsky.social · 17/09/2026
Dr Ahmad Metwalley will provide valuable information on the productive management of globozoospermia and similar cases associated with sperm structural abnormalities or fertilization deficiency. doi.org/10.1016/j.rb... 3/6
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Reproductive BioMedicine Online @rbmonline.bsky.social · 17/09/2026
RBMO Editor Nico Garrido and Male Reproductive Health and Fertility Section Editor Sandro Esteves will host this session of talks and panel discussion on the latest advances in sperm standards and male infertility management. 2/6
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Reproductive BioMedicine Online @rbmonline.bsky.social · 17/09/2026
Reproductive BioMedicine Online invite you to the 17th edition of our quarterly webinar series, in this special session with our andrology editors and special guest speakers. Register now, and read this thread for more details! bit.ly/RBMOlive17 1/6
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Reproductive BioMedicine Online @rbmonline.bsky.social · 17/09/2026
The wave motion quantification approach developed by Sania Latif and her research team, showcased in this new paper, provides an objective, reproducible method for assessing uterine peristalsis on TVS. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 17/09/2026
This systematic review discusses the impacts of idiopathic premature ovarian insufficiency on pregnancy, and emphasize the need for well-designed future studies in this field. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 16/09/2026
The preliminary findings in this new study shows that endometriosis is associated with a distinct follicular fluid steroid profile during ovarian stimulation, and may contribute to the infertility associated with the condition. doi.org/10.1016/j.rb... #FemaleReproductiveHealthAndFertility
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Reproductive BioMedicine Online @rbmonline.bsky.social · 15/09/2026
In this new Countercurrent contribution, Maria Longo and Antonio La Marca discuss conceptual, biological, and clinical issues around the renaming of polycystic ovary syndrome (PCOS) to “Polyendocrine Metabolic Ovarian Syndrome” (PMOS). doi.org/10.1016/j.rb... RBMOcountercurrent #PCOS #PMOS
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Reproductive BioMedicine Online @rbmonline.bsky.social · 15/09/2026
This large retrospective cohort study of more than 1000 fresh embryo transfers found no association between embryo exposure time to a hyaluronic acid-enriched transfer medium (EmbryoGlue) and live birth rates. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 14/09/2026
This new study supports the clinical adoption of quantitative hormonal monitoring for patients attempting to conceive and provide the validation needed for expanded research into personalized reproductive health management. The full paper is available open access, now: doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 11/09/2026
This study compares six commercial AI ploidy algorithms across 1000 PGT-A-validated blastocysts. Though one system was developed explicitly for ploidy prediction, all algorithms displayed a similar pattern of euploidy enrichment across higher score strata. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 11/09/2026
This scoping review aims to synthesise existing evidence, identify gaps in the literature and propose a committee opinion on 2.1PN zygotes, including a working provisional definition, to guide clinical practice and future studies. doi.org/10.1016/j.rb...
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Reproductive BioMedicine Online @rbmonline.bsky.social · 10/09/2026
This new study reassure patients undergoing multiple planned oocyte cryopreservation cycles that a second ovarian stimulation immediately or up to 180 days after the first oocyte retrieval is not inferior to an intercycle interval of 29–90 days. doi.org/10.1016/j.rb...
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