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New questions will provide new answers

Much of the intense controversy that swirls around antidepressants arises from not understanding how they help.

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The intense situation where decisions are made

Vicious cycles are everywhere once you recognize them

EMPH is an open access Oxford University Press journal sponsored by the International Society for Evolution, Medicine, and Public Health

Severely limiting the power of genetic predictions

Join us as we celebrate NCSE's 2025 Friend of Darwin and Friend of the Planet awardees. This online event is free and will include a Q&A after brief comments from the winners. This year's Friend of D...

But foraging theory is crucial for understanding it

This post is adapted from my 2016 essay that inspired the 2025 PNAS Nexus article with Guru Madhavan and Jay Labov on the origins of failure in bodies and machines.

Randy Nesse's Essays on why evolution left us vulnerable to sickness, suffering, and simplistic thinking. Click to read Nessays, by Randolph Nesse, a Substack publication. Launched 3 days ago.

“Individuals with disorders often have advantages, but that does not make the disorder an adaptation.”

PDF | Why do genes for mental disorders persist? This article argues it is because traits with a cliff-edged fitness function are shaped to a... | Find, read and cite all the research you need on Rese...

Scientists who have dedicated their careers to studying autism remain highly skeptical that a definitive answer to what causes autism can be reached within a few short months — if at all.

Abstract. Engineers have long studied the origins of design features that make machines prone to failure, but biologists have only recently begun investiga

Abstract. Engineers have long studied the origins of design features that make machines prone to failure, but biologists have only recently begun investiga

Randolph M. Nesse, MDnesse@umich.edu@RandyNesse@RandyNesse.bsky.social See you at ISEMPH2025 July 5-10, Nashville, TN

Welcome! You are invited to join a meeting: Club Ev Med: Bringing Up Baby. After registering, you will receive a confirmation email about joining the meeting.