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Rachel Yan

@rachelyan.bsky.social

Reposted by Rachel Yan

xinhexue.bsky.social @xinhexue.bsky.social · 28/12/2024

Excited to share my latest preprint on establishing a generalizable toolkit for decoding the gene regulatory landscape using two types of CRISPR screens. Big thanks to my amazing mentor @nevillesanjana.bsky.social for the in-depth thread below. Looking forward to feedback and comments!

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Reposted by Rachel Yan

Neville Sanjana @nevillesanjana.bsky.social · 26/11/2024

Delighted to share new work from our lab: MultiPerturb-seq 🎛️ ❌ ↕️ Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.

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Reposted by Rachel Yan

Nature Biotechnology @natbiotech.nature.com · 21/11/2024

Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling go.nature.com/4hXER5O

go.nature.com

Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling - Nature Biotechnology

MultiPerturb-seq profiles gene expression and chromatin accessibility in single-cell pooled CRISPR screen.

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