iiinova — where your digital self keeps evolving

rachelkarchin.bsky.social @rachelkarchin.bsky.social · 26/01/2026

New preprint! Structural variant evolution + cancer WGS. SV cancer cellular fraction + SV phylogenies. In longitudinal mCRPC on bipolar androgen therapy. hyper-rearranged subclones are pruned, resistant lineages expand. tinyurl.com/yvpystvt @laurasenamd.bsky.social #ProstateCancer #PrecisionOncology

tinyurl.com

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rachelkarchin.bsky.social @rachelkarchin.bsky.social · 16/01/2026

🚨 New preprint! We introduce PICTographPlus — a method to recover clone‑specific transcriptomes from bulk DNA + RNA sequencing (no single‑cell required!). 🧬💻 See bioRxiv 👉 www.biorxiv.org/cgi/content/... @fertiglab.bsky.social @break-cancer.bsky.social #CancerGenomics #TumorEvolution #Bioinformatics

biorxiv.org

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rachelkarchin.bsky.social @rachelkarchin.bsky.social · 15/03/2025

Excited to share new joint publication with the Tychele Turner lab at WashU now published in Cell Genomics! We do a proteome-wide assessment of differential missense variant clustering in neurodevelopmental disorders and cancers and find some interesting differences! tinyurl.com/2p9j559n

pubmed.ncbi.nlm.nih.gov

Proteome-wide assessment of differential missense variant clustering in neurodevelopmental disorders and cancer - PubMed

Prior studies examining genomic variants suggest that some proteins contribute to both neurodevelopmental disorders (NDDs) and cancer. While there are several potential etiologies, here, we hypothesiz...

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rachelkarchin.bsky.social @rachelkarchin.bsky.social · 25/02/2025

Karchin Lab at Johns Hopkins is excited to announce a postdoctoral position focused on developing innovative methods in computational immuno-oncology. Great opportunity if you are passionate about advancing cancer immunotherapy and bioinformatics. Learn more/apply: karchinlab.org/join-us/

tinyurl.com

Join us – Karchin Lab

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rachelkarchin.bsky.social @rachelkarchin.bsky.social · 25/02/2025

The Karchin Lab at Johns Hopkins is excited to announce a postdoctoral position focused on developing innovative methods in computational immuno-oncology. A great opportunity for researchers passionate about advancing cancer immunotherapy and bioinformatics. Learn more/apply: tinyurl.com/25ehczwb

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rachelkarchin.bsky.social @rachelkarchin.bsky.social · 25/02/2025

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