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Rabi Hanna - Cell & Gene therapy Doc

@rabihannamd.bsky.social
241 followers 51 following 53 posts

Chief of Pediatric hem-Onc & BMT @ClevelandClinic #CleClinicCancer @cleclinickids #CleClinicPedsCancer #ChildhoodCancer #pedcsm #bmtsm. Posts are my own opinion.

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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 02/04/2026
So proud to be part of these studies and advance #GeneEditing therapies for #SCD and #TDT by editing gamma globin promoters and mimic nature like persistent feral haemoglobin. Thanks 🙏 for patients , research team @clevelandclinic.bsky.soci and great team of investigators 👏🎉
nejm.org
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 02/04/2026
so honored and excited tos hare on behalf of all our team and co-investigators the results of RUBY study #EditasMedicine that used novel first-in human CRISPR-Cas12a Gene Editing of HBG1 & HBG2 Promoters to treat #SickleCell Disease which was published today in @nejm.org www.nejm.org/doi/full/10....
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Reposted by Rabi Hanna - Cell & Gene therapy Doc
Aaron Logan, MD, PhD, MPhil @hemedoc.bsky.social · 08/12/2025
#ASH25 #bmtsm Soiffer: although cGVHD reduced overall, this benefit of cryo was not seen in pts getting PTCy. Given higher OS in spite of lower GRFS with cryo, fresh grafts remain the preferred standard (but still reasonable when logistically useful).
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 09/12/2025
Dr. Lucy Fox for outstanding talk at #LBA #ASH25 Whole Genome Sequencing upfront in large cohort of adult & pediatric pts with suspected IBMFS found high diagnostic rate (37.1%) - cost is ~8100 $ but expected to 📉 - impact on patient counselling & therapy - new discoveries
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 08/12/2025
Grateful for the wonderful ‘You Have Been ASH’d experience ✨. WE are the ones who should be thanking @ash.hematology.org for bringing us together, building community, and inspiring the next generation of trainees 🙌. Hem is simply the best — a family and a field that inspires us every day ❤️ #ASH25”
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 08/12/2025
It’s always inspiring to meet global colleagues, mentors, and mentees at the #ASH25 meeting. Medicine is the ultimate team sport — we learn, grow, and advance together. Grateful to @ash.hematology.org for fostering a truly global hematology community. 🌍🩸
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Reposted by Rabi Hanna - Cell & Gene therapy Doc
Aaron Logan, MD, PhD, MPhil @hemedoc.bsky.social · 06/12/2025
#ASH25 #bmtsm Kuball: no strong evidence for different outcomes using frozen G mobilized DLI (ie, leftover from graft collection) vs fresh steady state collection.
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 06/12/2025
Dr. Lachelle Weeks presented interesting data about #CHIP present in #SCD patient and I am surprised to see it as early in childhood (up to 7% by age 11) and how the incidence increases. It was not observed in sickle trait. Unknown are the implications for 🧬 #GeneTherapy #ASH25
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 06/12/2025
Congratulations 🎉👏 Dr. Crawford Strunk @clevelandclinic.bsky.social for a powerful #ASH25 presentation on integrating palliative care into SCD management. Inspiring to see how this approach not only enhances patient well-being but also improves length of stay #SickleCell
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 05/12/2025
🚀 Calling all ASH trainees! This is your chance to shape the future of hematology. Join the ASH Trainee Council and amplify your voice, your ideas, and your impact. Scan the code below and apply today! 🌟 #ASH25 #HemeTrainees #Leadership
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 05/12/2025
Grateful for the opportunity to join #BloodBuddies at #ASHApalooza #ASH25 @ash.hematology.org ‬⁩ Fast-paced mentorship, big ideas, and even bigger passion from trainees — truly energizing. I also learn from them more than they know- it is like highway /knowledge flows both ways
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 05/12/2025
Excited to participate in #ASH-a-palooza at #AS25 #BLOODBUDDIES Designed for undergraduates, medical and graduate students, residents, and fellows, ASH-a-Palooza provides a variety of opportunities for trainees attending @ash.hematology.org meeting #ASH25 youtu.be/aVAJg-qp99Y
youtu.be
ASH-a-Palooza
YouTube video by American Society of Hematology
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 30/10/2025
How immuniry change wuth age - age-dependent TH2 bias in CD4 T cells and CD8 T cells is broadly driven by reduction in T cell signalling strength over time www.nature.com/articles/s41...
nature.com
Multi-omic profiling reveals age-related immune dynamics in healthy adults - Nature
This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes w...
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 06/10/2025
Grateful to our amazing @CleClinic_PHO team for shining so brightly at #LightTheNight 🌟 Your passion and advocacy bring hope to leukemia & lymphoma patients and families every day. Together, we’re lighting the path toward a cure. ❤️🕯️ #LLS #TeamClevelandClinic @bloodcancerunited.bsky.social
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 06/09/2025
You want to feel good and 🤩👏… come to @velosano . Nothing feels as good as being with previous #ChildhoodCancer patients who are now #Survivors and #riding for the #Cure
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 06/09/2025
Here we go ; safe ride to all #Riders @bikeVeloSano 25 miles. 🙏thank you so much for all you do to raise $ for #CancerResearch at @ClevelandClinic 💯 for the #Cure . Cancer impact goes beyond one patient , one family … it affects the community and together 💪 can make an impact
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 05/07/2025
The impact of CMV reactivation on mortality after chimeric antigen receptor T-cell therapy url: ashpublications.org/bloodadvance...
ashpublications.org
The impact of CMV reactivation on mortality after chimeric antigen receptor T-cell therapy
TO THE EDITOR:
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 25/06/2025
Join us on July 26 at the Cleveland Metroparks Zoo for a one-of-a-kind bike ride for kids ages 3–10 to raise funds for pediatric #cancer #research at @clevelandclinic.bsky.social . www.velosano.org/trike-bike www.velosano.org/trike-bike/
velosano.org
Trike & Bike | VeloSano
Kids can help fight pediatric cancer with Trike & Bike. Join community bike rides supporting Cleveland Clinic Children’s. 100% of funds go to research.
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 15/06/2025
This is sad news abd huge loss to #Medicine #Pediatric and #Science in general . May his menory be a blessing . pioneerpressobits.space/atul-butte-s...
pioneerpressobits.space
Atul Butte San Francisco, CA Obituary, American pediatrician and UCSF professor Atul Janardhan Butte Dies From Cancer - Pioneer
Dr. Atul Janardhan Butte, San Francisco, CA Obituary, Death: The vibrant San Francisco and global scientific communities mourn the loss of Dr. Atul Janardhan Butte, 55, who passed away on June 13, 202...
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 09/05/2025
Mentorship is a powerful way to give back in #PedsHemOnc. I am so honored to be among #mentors at the American society of pediatric hematology - oncology speedy mentorship supporting the next generation boosts career satisfaction, fosters personal growth & strengthens our field for the future.
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 01/05/2025
Dr. Caitlyn Duffy from @stjude.bsky.social presented great talk at poem_group about Implementation science in leukemia 1- discussed the 17 year odessy - translation of discovery to delivery 2- EPIS implementation framework
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 01/05/2025
So grateful to be invited to #POEM 4th Scientific Conference! Connecting with ped oncologists to improve care & access for kids with cancer has been truly inspiring. 👏🎉 Dr. rawad rihani and Dr. Gevory Tamamyan for fantastic reception to start #POEM2025 #PediatricOncology #CancerCare
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 24/04/2025
open.spotify.com/episode/4SnN...
open.spotify.com
Finding the Words: Talking Cancer with Children
Little Health: A Cleveland Clinic Children’s Podcast · Episode
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 05/04/2025
A heartfelt thank you to our incredible team at Cleveland Clinic Children’s for coming together in support of St. Baldrick’s Foundation. Your dedication, generosity, and passion for making a difference in the lives of children with cancer is truly inspiring #StBaldricks m.youtube.com/watch?v=azNy...
m.youtube.com
St. Baldrick's Foundation foundation hosts head shaving event, raises money for kids with cancer
The St. Baldrick's Foundation hosted a fundraising event for kids with cancer Sunday afternoon.
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 05/04/2025
Thank you 👏 Dr. Jim Fernandez for organising great conference #PrimaryImmunodeficiency at @ClevelandClinic and great talk about #IVIG . It is amazing to see the use increase significantly. Did you know it takes 8-9 months to make IVIG and it approximately collected from 15,000 donors
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 04/04/2025
Great advice by Troy Torgerson about what to do when you have VUS “variable unknown significance “ at @clevelandclinic.bsky.social #PrimaryImmuneDeficiency symposium
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 04/04/2025
Still time to join us at #UodateInPrimaryImmunodeficiency at @clevelandclinic.bsky.social endorsed by immune deficiency foundation Very educational agenda and world renowned experts discussing diagnosis and management of different immune deficiencies www.clevelandclinicmeded.com/live/courses...
clevelandclinicmeded.com
Join us for the inaugural Updates in Primary Immunodeficiency CME symposium. This course provides an educational forum for faculty to deliver in-depth reviews of common and rare inborn errors of immunity (IEI), a group of more than 400 complex, chronic disorders.
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Reposted by Rabi Hanna - Cell & Gene therapy Doc
BMT InfoNet @bmtinfonet.bsky.social · 02/04/2025
Celebrating a Second Chance at Life Symposium May 3 - 9, 2025 A week packed full of information, inspiration and community. symposium.bmtinfonet.org
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 30/03/2025
The fight against # ChildhhodCancer is not just medical challenge - it is calling - beyond medication to wholistic care So proud of our music therapist 🎉👏 Emily Ervin @CleClinicKids for supporting kids - see picture below 👇 with one of our kids cutting her hair
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 30/03/2025
So proud and inspired by our team : Preston , Katie and Stacey participating in @clevelandclinic.bsky.social #StBaldrick shave for the cure event We are doing what we do to support kids & their families and organisations like St Baldrick so we can do research to find more cure and better therapies
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 21/03/2025
So excited to welcome our #Pediatric residents at @clevelandclinic.bsky.social To join all our care givers in our mission “Caring for life, researching for health, educating those who serve”
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 12/03/2025
Childhood cancer survivors have a more than two-fold increased risk of developing melanoma during their lifetime, compared to the general population, as well as a two-fold increased risk of death associated with a melanoma diagnosis consultqd.clevelandclinic.org/study-reveal...
consultqd.clevelandclinic.org
Study Reveals New Clues Into Childhood Cancer Survivors’ Increased Risk of Melanoma
Childhood cancer survivors have a more than two-fold increased risk of developing melanoma during their lifetime, compared to the general population, as well as a two-fold increased risk of death asso...
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 09/03/2025
fotoshare.co/i/20j6sp6 so excited to celebrate the grand finale of #LLS
fotoshare.co
Student Visionaries of the year
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 26/02/2025
The Pediatric Rare Disease Priority Review Voucher Program, incentivizing research peds rare diseases expired Dec/2025. Research for #ChildhoodCancer is affected . ask Congress to reauthorize the program by supporting the Give Kids a Chance Act of 2025 (H.R. 1262) www.votervoice.net/mobile/Bioco...
votervoice.net
Urge Reauthorization of the Rare Pediatric Disease Priority Review Voucher Program
Rare pediatric diseases are an area with extreme unmet need in our health care ecosystem. The challenges associated with rare diseases, such as small populations, unknown cause and/or course of the di...
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 26/02/2025
so honored to be part of the team led by Dr. Adetola kassim #BMTCTN CTN1507 Haplo-HCT for patients with severe sickle cell disease; - Of 42 Adult pts underwent haplo-HCT: 95% alive at 2 yrs, 88% are potentially cured at fraction of the cost of gene therapy evidence.nejm.org/doi/pdf/10.1...
evidence.nejm.org
Haploidentical Bone Marrow Transplantation for Sickle Cell Disease
Related human leukocyte antigen (HLA)–haploidentical bone marrow transplantation (BMT) with posttransplant cyclophosphamide may be curative for sickle cell disease. However, graft failure, severe g...
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 13/02/2025
Great job 👏 👏 by Dr. Mark Walters @uscfb.bsky.social to present RUBY study sponsored @editasmed -Gene therapy for #SCD - sustained normal hemoglobin and hgb F above >40% - F cells >>99.3% - pain free in 27/28 patients - improved QOL
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 06/02/2025
Watch this incredible story and then ask me why i chose to be pediatric oncologist- A fight for survival 💪 These kids are inspiration Our team of clinician and scientists working on #Tumor Vaccine for Ewing Sarcoma www.wkyc.com/article/news... www.wkyc.com/article/news...
wkyc.com
Cleveland Clinic works on breakthrough cancer vaccine, even as funding for pediatric research lags
A 12-year-old Atlanta girl has turned to Cleveland researchers for treatment of her Ewing Sarcoma, and the hope a breakthrough vaccine is on the way.
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 06/02/2025
2024 was an incredible year of innovation for our Division of Pediatric Hematology & Oncology! We’re proud to share some of our key accomplishments from the past year: www.linkedin.com/posts/clevel...
linkedin.com
Cleveland Clinic Children’s on LinkedIn: 2024 was an incredible year of innovation for our Division of Pediatric…
2024 was an incredible year of innovation for our Division of Pediatric Hematology & Oncology! We’re proud to share some of our key accomplishments from the…
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 06/02/2025
I enjoyed listening to tbe new @clevelandclinic.bsky.social podcast about pediatric health related topics “Little health” open.spotify.com/episode/2uKa...
open.spotify.com
Eat, Sleep, Poop, Grow!
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 05/02/2025
Cord blood transplant was associated with less risk of relapse in MRD positive AML getting MAC regimen HCT. www.nature.com/articles/s41...
nature.com
Relationship between donor source, pre-transplant measurable residual disease, and outcome after allografting for adults with acute myeloid leukemia - Leukemia
Leukemia - Relationship between donor source, pre-transplant measurable residual disease, and outcome after allografting for adults with acute myeloid leukemia
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 05/02/2025
AR Marderstein et al showed increased mitochondrial mass & oxidative stress in #Downsyndrome led to mutations in regulatory regions genes in HSCs which explain increased #Leukemia in DS Single-cell multi-omics of human fetal blood in #Down Syndrome @nature.com www.nature.com/articles/s41...
nature.com
Single-cell multi-omics map of human fetal blood in Down syndrome - Nature
Using single-cell and multi-omics data of fetal blood, a high-resolution molecular map of dysregulated haematopoiesis in Down syndrome is provided.
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 22/01/2025
Transplant-Free Strategies for Low-Risk Relapsed Hodgkin Lymphoma offer excellent cure and should be considered for selected patients to avoid long term side effects of high dose chemo / autologous transplant www.medpagetoday.com/hematologyon...
medpagetoday.com
Enthusiasm for Transplant-Free Strategies for Low-Risk Relapsed Hodgkin Lymphoma
Studies show promising EFS, PFS, and OS at 3 to 8 years
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 21/01/2025
Thrilled to be again in Kuwait and excited to hear about #PedBMT program growth presented by Dr Sondus Alsharidah at the 4th Kuwait 🇰🇼 Ped BMT & Gene therapy conference. 👏🎉 work. BMT is not quick surgery and rather a long journey and best care is local where patients families can be supported
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 13/01/2025
Thank yoh @vjhemonc.bsky.social for highlighting advances and barriers to make gene therapy for SCD more accessible www.vjhemonc.com/video/odfje4...
vjhemonc.com
The promise of gene therapy approaches in SCD and barriers that remain to their implementation | VJHemOnc
In this video, Rabi Hanna, MD, Cleveland Clinic, Cleveland, OH, comments on the promise of gene therapy approaches in the...
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Reposted by Rabi Hanna - Cell & Gene therapy Doc
Olli Lohi @lohiolli.bsky.social · 09/01/2025
Children with ETV6::RUNX1 or high-hyperdiploid B-ALL have excellent 5-year EFS (97.7% and 94.7%) with low-intensity therapy. However, high-hyperdiploid B-ALL with slow MRD response needs improved treatments 👇👇👇 ashpublications.org/blood/articl...
ashpublications.org
Outcomes in patients with ETV6::RUNX1 or high-hyperdiploid B-ALL treated in the St. Jude Total Therapy XV/XVI studies
Key PointsAmong NCI high-risk patients, 93% with ETV6::RUNX1 and 54% with hyperdiploid B-ALL had excellent outcomes with low-intensity therapy.NCI high-ris
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 07/01/2025
excited to share our commentary review @jama oncology for Jon-BMT option in relapsed Hodgkin lymphoma . Nontransplant Treatment for Relapsed Pediatric Hodgkin Lymphoma—Less Is More jamanetwork.com/journals/jam...
jamanetwork.com
Nontransplant Treatment for Relapsed Pediatric Hodgkin Lymphoma—Less Is More
Current up-front therapeutic approaches for classic Hodgkin lymphoma (cHL) in children and young adults aim to reduce treatment intensity to minimize long-term treatment-related morbidity. This strate...
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 26/12/2024
ashpublications.org/blood/pages/...
ashpublications.org
2024 Most Read Articles | Blood | American Society of Hematology
2024 Most Read Articles | Blood | American Society of Hematology Top Ten Most Read Articles in 2024 Blood is pleased to announce the following most read articles that were published in 2...
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Rabi Hanna - Cell & Gene therapy Doc @rabihannamd.bsky.social · 10/12/2024
What a fantastic late breaking abstract fantastic by Françoise Bernaudin ⁦‪@ASH_hematology‬⁩ #ASH24: long term outcomes in DREPAGREFFE study evaluating all-HSCT in # SCD with abnormal cerebral velocity. - alloSCT provided better primary prevention of stroke, ⬆️social QoL, working memory
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Reposted by Rabi Hanna - Cell & Gene therapy Doc
Cleveland Clinic @clevelandclinic.bsky.social · 10/12/2024
It was a special connection the moment Katie met the woman who donated a portion of her liver and gave her son, Sonny, a new life. “Sandy gave a piece of herself to save my baby’s life. Organ donation is truly an unconditional gift.” More: cle.clinic/3O66NXk
cle.clinic
Living Donor Meets Boy She Helped Save, Family Shares Gratitude For Unconditional Gift
When Sandy became a living organ donor, she didn’t know she'd ultimately help a little boy named Sonny, who was suffering from biliary atresia.
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Reposted by Rabi Hanna - Cell & Gene therapy Doc
Olli Lohi @lohiolli.bsky.social · 09/12/2024
Fascinating findings from the @cmullighan.bsky.social team: ctDNA was identified in all cases of hematological malignancies, in 19 out of 38 patients with solid tumors, and in just 1 out of 18 brain tumor patients 👇👇👇 www.nature.com/articles/s41...
nature.com
Genomic profiling of circulating tumor DNA for childhood cancers - Leukemia
Leukemia - Genomic profiling of circulating tumor DNA for childhood cancers
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