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QSPainRelief EU Project @qspainrelief.bsky.social · 07/07/2026

This initiative aims to better understand people living with chronic pain and contribute to improving future pain treatment. This survey is part of the EU-funded QSPainRelief project. Study: ClinicalTrials.gov NCT07453524. On behalf of Pain Alliance Europe & the QSPainRelief-patientPREF study team.

clinicaltrials.gov

ClinicalTrials.gov

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QSPainRelief EU Project @qspainrelief.bsky.social · 07/07/2026

Do you live with #ChronicPain? 👉 Take this short survey: lnkd.in/e3XT8YPK 🙂 Share your views on #painmanagement, satisfaction, #SideEffects, and what you value most from your pain medication. ☝ Every #patient experience is different. 🦻 We want to hear your voice! #painresearch #painrelief

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QSPainRelief EU Project @qspainrelief.bsky.social · 03/10/2025

✨Final spotlight of this series: Our open access protocol on a self-medication #MouseModel of #ChronicPain that helps assess spontaneous #PainRelief & #DrugAbuse liability 🔗 doi.org/10.21769/Bio... Cabañero et al. (2022), co-authored by Beltrán Álvarez & Rafael Maldonado #Neuroscience #Analgesics

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QSPainRelief EU Project @qspainrelief.bsky.social · 03/10/2025

5️⃣ García-Blanco et al. (2002): www.jci.org/articles/vie... 📖 miRNA signatures associated with vulnerability to food addiction in mice & humans 💡Common #miRNA #signatures in mice & humans may underlie vulnerability to #FoodAddiction. 💡Targeting those miRNAs may modify maladaptive eating phenotypes.

jci.org

JCI - miRNA signatures associated with vulnerability to food addiction in mice and humans

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QSPainRelief EU Project @qspainrelief.bsky.social · 03/10/2025

2️⃣García-Blanco et al., 2023 www.sciencedirect.com/science/arti... 📖 #CB2 #CannabinoidReceptor & the development of food addiction in mice 💡CB2R is a modulatory node in the control of hedonic feeding and vulnerability to #FoodAddiction, making it a potential therapeutic target for eating disorders

sciencedirect.com

Role of CB2 cannabinoid receptor in the development of food addiction in male mice

The endocannabinoid system plays an important role in multiple behavioral responses due to its wide distribution in the central nervous system. The ca…

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QSPainRelief EU Project @qspainrelief.bsky.social · 03/10/2025

🧬🐭👩‍🦰👨‍🦰 Translational research - from mice to humans - was central to #QSPainRelief: For better #PainRelief, safer #PainMedication and improved #ChronicPain treatment. ✅ Less pain 😵‍💫 Fewer side effects ☺️ Better QoL ✨ Here are 5 key papers about 🧠-mechanisms linked to #addiction #cognition #impulsivity

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QSPainRelief EU Project @qspainrelief.bsky.social · 03/10/2025

A more #PainRelief-relevant follow-up of the 2020 Sci. Rep. paper is this article by Ricarte, Dalton & Giraldo (2021), a year later: 🔗 doi.org/10.1021/acs.... 🧬 Structural assessment of #agonist #efficacy at the μ-opioid receptor #MOR 👉 #morphine and #fentanyl elicit different activation patterns

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QSPainRelief EU Project @qspainrelief.bsky.social · 03/10/2025

🔬 Wanna know the P-values for #agonist-dependent #GPCR activation? 👏 One of our 2 high-impact Nature publications was also the 1st QSPainRelief article: 📈 Bruzzese, Dalton & Giraldo (2020) present their #MolecularDynamics work & the best statistics to analyse it. 🔗 www.nature.com/articles/s41...

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QSPainRelief EU Project @qspainrelief.bsky.social · 03/10/2025

Here's another important QSPainRelief publication about allosteric sites at #GPCRs: They can be identified by looking at how strongly certain receptor sites are coupled to #conformational changes that occur during activation. 🔗 doi.org/10.3390/ijms... #allostery #pharmacology #receptors #ligands

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QSPainRelief EU Project @qspainrelief.bsky.social · 03/10/2025

Speaking of #allostery: What happens when you mutate the #CannabinoidReceptor (CB1) in silico with a single-point mutation? Find out👉: doi.org/10.1021/acso... Spoiler😉: The F237L mutation mimics #allosteric #ligand effects, globally altering #receptor conformations and hindering activation #GPCR

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QSPainRelief EU Project @qspainrelief.bsky.social · 03/10/2025

🎯Feature Alert 🚨 This paper delves into how #BindingKinetics reshape our understanding of #allosteric modulation. When it comes to cooperativity effects, it's all about 👉 WHERE molecules bind 👉 HOW FAST 👉 and in WHICH SEQUENCE 🔗 doi.org/10.1016/j.dr... #allostery #pharmacology #DrugDesign #GPCRs

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QSPainRelief EU Project @qspainrelief.bsky.social · 03/10/2025

🚀 Time-dependent #ligand-receptor #BindingKinetics and functionality in a #heterodimeric receptor model by Ortiz et al. (2024): Predicting how 2 drugs bind to a receptor complex over time - with implications for combination-therapies and #DrugDesign💊 🔗 doi.org/10.1016/j.bc... #Pharmacology #GPCRs

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QSPainRelief EU Project @qspainrelief.bsky.social · 03/10/2025

🔦 Spotlight on link.springer.com/article/10.1... 🧠 Using the LeiCNS-PK3.0 PBPK model, they predicted mouse #brainECF #pharmacokinetics for 10 drugs ✅ Accurate for 7 drugs ✅ First mechanistic #CNS PBPK #model in mice ✅ Strong translational potential #TranslationalPharmacology #DrugDevelopment

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QSPainRelief EU Project @qspainrelief.bsky.social · 03/10/2025

The paper by Budda et al. (2024) relates to the earlier publication by Gülave et al. (2023): doi.org/10.1016/j.ej... 🧠The transport of #morphine across the #BBB is non-linear - this is important for #receptor #occupancy predictions. Find out how BBB dynamics inform smarter, safer dosing strategies!

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QSPainRelief EU Project @qspainrelief.bsky.social · 03/10/2025

🧠 Non-linear blood-brain barrier #BBB transport & dosing influence #receptor #occupancy ratios of #morphine and #MorphineMetabolites (M3G + M6G) in the #pain matrix. 💡This might also explain some inter-individual differences! 🔗 bpspubs.onlinelibrary.wiley.com/doi/10.1111/... #ChronicPain #opioids

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Reposted by QSPainRelief EU Project

Juvenile Arthritis Research @jarproject.bsky.social · 14/06/2025

We have exceptional treatments for RMDs but that doesn't always mean the chronic pain is treated. We need to be open to pain specialists. Patients need to keep advocating for themselves when still in pain despite their RMD appearing under control. Nadia Malliou at #eular2025 @eular.org

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QSPainRelief EU Project @qspainrelief.bsky.social · 03/10/2025

🔬By Bertayli et al (2024): PK-PD modelling of #morphine, #pregabalin & their combination shows synergistic #analgesia. Potential impact: 👉 Lowering #opioid doses 👉 Maintaining treatment efficacy 👉 Reducing side effects & abuse liability 🔗 www.page-meeting.org/default.asp?... #ChronicPain #Pain

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QSPainRelief EU Project @qspainrelief.bsky.social · 03/10/2025

📖 Just published 💊 👉 Introducing a rigorous theoretical framework for better #quantification of #drug-target #ResidenceTime (RT) - a key metric in #BindingKinetics that has lacked a firm quantitative foundation to date 👏 🔗 www.sciencedirect.com/science/arti... #Pharmacology #ComputationalBiology

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QSPainRelief EU Project @qspainrelief.bsky.social · 03/10/2025

🧪 Our new paper on the #pharmacokinetics of P-glycoprotein substrates in #brainECF shows how #invitro transport data can guide #invivo 🧠🐭🚶‍♀️predictions, but that high variability still limits the robustness of these predictions. 🔗 link.springer.com/article/10.1... 👉LeiCNS-PK3.4 PBPK model #CNS #brain

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QSPainRelief EU Project @qspainrelief.bsky.social · 03/10/2025

🫶 Our recent review shows that #SocialSupport is a powerful boost for #MentalHealth in #ChronicPain ⚡ , but its impact on pain intensity and daily function is less clear. 👉 Social support is crucial, but HOW matters 🔗 doi.org/10.1371/jour... #QoL #PainResearch #Pain @plosone.org @efic.bsky.social

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QSPainRelief EU Project @qspainrelief.bsky.social · 01/10/2025

🧠 Predicting how well #drug molecules cross the blood-brain barrier: Gülave et al. built a #MachineLearning model for the unbound brain-to-plasma partition coefficient (98 compounds). link.springer.com/article/10.1... 👉Best algorithm: Random Forest 💡Great for #CNS drug discovery! #BBB #PBPK #ML

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QSPainRelief EU Project @qspainrelief.bsky.social · 30/09/2025

💊 Morphine is a P-glycoprotein substrate, but do P-gp inhibitors meaningfully change #CNS exposure? 🧠 Likely not: A physiology-based pharmacokinetic #PBPK model predicts negligible impact across populations. #BBB #DrugInteractions #morphine #modelling #brain 🔗 link.springer.com/article/10.1...

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QSPainRelief EU Project @qspainrelief.bsky.social · 29/09/2025

Preoperative #susceptibility to secondary #hyperalgesia is associated with cough-evoked #pain 2 months after #thoracotomy (Gousset et al., 2025) 👉 onlinelibrary.wiley.com/doi/10.1002/... ⚕️Patients with high secondary hyperalgesia pre-op had more cough-evoked pain 2 months later. #PainPrediction

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QSPainRelief EU Project @qspainrelief.bsky.social · 26/09/2025

🧠 Central sensitisation drives #ChronicPain. This PhD thesis by Solenn Gousset (2025) bridges experimental pain models and clinical perspectives, exploring methods to measure and predict #CentralSensitisation. 👉 Explore the mechanisms behind persistent pain! 🔗 dial.uclouvain.be/pr/boreal/ob...

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QSPainRelief EU Project @qspainrelief.bsky.social · 25/09/2025

🧠 Ever wondered what affects how #morphine works in the brain? This modelling study found #beta-endorphin to be a major player in how morphine occupies its µ-opioid receptors (MORs) in rat #hypothalamus 🐭 #EndogenousOpioids matter, folks! #BindingKinetics #MOR www.sciencedirect.com/science/arti...

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QSPainRelief EU Project @qspainrelief.bsky.social · 24/09/2025

💡What happens when you combine 2 analgesics? 🔬 Bakker et al. (2025) used a nociceptive test battery to investigate #morphine + #pregabalin. Result: Increased #PainTolerance, only minimal side effects. A promising step toward safer #PainRelief & lower #opioid doses. pubs.acs.org/doi/10.1021/...

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QSPainRelief EU Project @qspainrelief.bsky.social · 20/09/2025

20% live with #ChronicPain - many without effective treatment The QSPainRelief database uses published data, existing meds & advanced models to help design more effective therapies 🎥 Intro video: youtu.be/0VWoc2fqks8 🔗 Database: qspainrelief.lacdr.leidenuniv.nl #PainRelief #PersonalisedMedicine

youtu.be

Introduction to the QSPainRelief Database (by Daan van Valkengoed, Leiden University, NL)

YouTube video by concentris research management

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QSPainRelief EU Project @qspainrelief.bsky.social · 30/07/2025

🎓 Dive into the complexity of #OpioidReceptors with Prof. Andrea Bedini (from @unibo.it) in his insightful Masterclass. 👉 A must-watch for anyone interested in #MOR, #KOR, and chronic pain therapeutics! ▶️ youtu.be/dcGBm03nvhI #GPCR #ChronicPain #Pharmacology @iasp.bsky.social @efic.bsky.social

youtu.be

QSPainRelief Masterclass - Opioid Receptors & Quantitative Systems Pharmacology (Andrea Bedini)

YouTube video by concentris research management

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QSPainRelief EU Project @qspainrelief.bsky.social · 28/05/2025

🧪 Day 2 Magic: 👉 Clinical efficacy, ethical considerations, and the final reporting 📰 👉 A power session on #dissemination, #IP, and how our #innovations will go commercial 🚀 👉 Brainstorming on next steps and funding pathways to keep our momentum going 💸 👉 Final wrap-up & virtual high-fives 🙌

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QSPainRelief EU Project @qspainrelief.bsky.social · 26/05/2025

🧠 Highlights from Day 1: 👉 Updates on our #QSPainRelief #ModelPlatform after a warm welcome by Liesbeth 👉 Deep dives into data management, in silico computations, cellular signalling, and preclinical validation 🔬 👉 Coffee-fueled discussions ☕ on how our model translates into real-world impact 💡

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QSPainRelief EU Project @qspainrelief.bsky.social · 26/05/2025

Wrapping things up for our final deliverables in fresh #SpringTime spirit: Our Steering Committee assembles for the last time as we shift into top-gear productivity 🚀until the end of June! 😎 #ChronicPain #PersonalisedMedicine #DrugCombinations #PainRelief @horizoneu.bsky.social @efic.bsky.social

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QSPainRelief EU Project @qspainrelief.bsky.social · 04/04/2025

🥳 Congrats, Solenn Gousset, from André Mouraux's group at Université catholique de Louvain for defending your PhD thesis "Novel approaches to investigate #CentralSensitization: From #experimental models to #clinical perspectives" on 25 March - what an accomplishment! 👏 #PainResearch #Neuroscience

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QSPainRelief EU Project @qspainrelief.bsky.social · 21/01/2025

🌟 Highlights ✨of the 6th #QSPainRelief General Assembly (GA) in Bologna from 9-11 Dec 2024. We still have much work ahead in 2025 but gained lots of energy & momentum during our final in-person GA! 💪 #PainRelief #ChronicPain #SystemsPharmacology #neuroscience #PersonalisedMedicine @efic.bsky.social

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QSPainRelief EU Project @qspainrelief.bsky.social · 16/01/2025

☺️ Welcome! 😊 You can now also follow us here on Bluesky. Spearheaded by ULEI (@unileiden.bsky.social), 10 partners joined forces for the QSPainRelief project in January 2020 to develop personalised #QSP (Quantitative Systems Pharmacology) based combinatorial treatments for #ChronicPain patients.

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