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EssJay PURPLE PURPOSE

@purplepurpose.bsky.social
1.5K followers 1.3K following 1.8K posts

Advocating progress on pancreas cancer, #BRCA, support for carers. Partner survived #PDAC 8+ yrs at MSKCC. Law (JD); science; marine life. #StandUpForScience #PancreaticCancer

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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 30/09/2026
Via The National Pancreas Foundation Emerging Treatments in Pancreas Cancer Nov 11 at 6 PM ET A webinar to help patients understand what’s new in pancreatic cancer treatment, emerging therapies, & genetic & tumor testing that may help identify treatment options. Register ⬇️ zoom.us/webinar/regi...
zoom.us
Welcome! You are invited to join a webinar: Emerging Treatments in Pancreatic Cancer. After registering, you will receive a confirmation email about joining the webinar.
Pancreatic cancer treatment continues to evolve, with researchers exploring new ways to detect, understand, and treat the disease. Advances in genetic testing, precision medicine, targeted therapies, ...
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 28/09/2026
#ChildoodCancerAwareness month is coming to an end. From that other site, a rare post ⬇️ — about which we can all agree — highlighting the courage of a child with cancer. RIP, Jake.
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 23/09/2026
Wordle 1,922 5/6* ⬜🟨🟨⬜⬜ ⬜🟨🟨🟨⬜ ⬜🟩🟨⬜🟨 ⬜🟩🟩🟩🟩 🟩🟩🟩🟩🟩
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 20/09/2026
White House Moves to Take Control of N.I.H. Grants www.nytimes.com/2026/09/20/s...
nytimes.com
White House Moves to Take Control of N.I.H. Grants
Federal officials are drafting an executive order that would place grants under review by an outside panel, the latest effort to redirect billions of dollars in research spending.
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Lempradl Lab @lempradllab.bsky.social · 17/09/2026
Thrilled to be at the #RallyForMedicalResearch with the Michigan delegation. Grateful to @faseborg.bsky.social for supporting my participation. #FundNIH
Michigan delegation with the rally for medical research in front of the Capitol building.
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 15/09/2026
Via Listgarten.org Tomorrow, explore new frontiers in pancreas cancer biology via zoom: the role of dietary fats in driving disease, disrupting the molecular pathways that fuel tumor growth, understanding how the nervous system influences cancer development. Register ⬇️ events.zoom.us/ev/Agolu169h...
events.zoom.us
Where Tomorrow’s Breakthroughs Begin
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 12/09/2026
Via pancan.org Triple your impact! Today, your support can go THREE TIMES as far to fuel breakthrough research, connect more patients to lifesaving care & drive progress in this unrelenting disease. This org was incredibly helpful during my hub’s pancreas cancer journey. pancan.org?form=FUNWQYW...
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 09/09/2026
Living up the road, CSHL was a big deal for me in high school with visits & AP courses. Thrust into the PDAC community as an adult, I followed David Tuveson’s breakthrough research at CSHL with great interest. I wish him well as the new director at Duke Cancer. medschool.duke.edu/news/david-t...
medschool.duke.edu
David Tuveson to join Duke Health as executive director of the Duke Cancer Institute
David Tuveson, MD, PhD, will join Duke Health as executive director of the Duke Cancer Institute (DCI), effective October 31, 2026. Tuveson, a preeminent cancer biologist, is currently the Roy J. Zuck...
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 06/09/2026
The admin’s disregard for health & safety led me down an internet rabbit hole to learn how Pseudomonas aeruginosa (and other bacteria) can survive in cleaning products recently recalled by CPSC. Erosion of safety standards & oversight = manufacturer shortcuts = pathogenic risk to citizens. Scary.
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 03/09/2026
Dolly & Gloria entered my consciousness in the 70s. Dolly’s quick, easy, wit taught me *not* to judge a book by its cover, while Gloria showed there is no one *right* way to be a woman. Both so smart & energetic. One beloved by all; the other frequently derided even by feminists. Giants, both. RIP.
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 26/08/2026
Today, the FDA approved Rasonque (daraxonrasib), a RAS inhibitor, for treatment of the most common form of pancreatic cancer. Congratulations & thanks to all the scientists, physicians, & patients who dedicated themselves to this moment. This is just the beginning! 💜 www.fda.gov/news-events/...
fda.gov
FDA Approves First in Class Targeted Therapy for Metastatic Pancreatic Cancer
The U.S. Food and Drug Administration today approved Rasonque (daraxonrasib), a RAS inhibitor for the most common form of pancreatic cancer—delivering a new treatment option to patients with advanced ...
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 06/08/2026
I know this is old & played, but how do they get away with selling bullshit wellness products with pitches that say things like “slows aging at the cellular level.” When nobody regulates this stuff, & there are no standards & the public eats it up, real, evidence-based science is hurt.
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Barb McQuade @barbmcquade.bsky.social · 22/07/2026
It’s so refreshing to see a senator who knows how to ask questions. Too often, witnesses deflect and the senator moves on. Ossoff does what a good trial lawyer does—persists until he gets an answer or a refusal to answer. Both responses can be deeply revealing.
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 23/07/2026
Trump’s science adviser told lawmakers yesterday that the administration intended to drastically overhaul the country’s approach to scientific research by shifting research funding away from universities & toward individual researchers and private companies. www.nytimes.com/2026/07/22/u...
nytimes.com
Trump’s Plan for Science: More Money for A.I., Less for Universities
Michael Kratsios, President Trump’s science adviser, proposed overhauling how the government funds research. Democrats said Mr. Trump’s actions had weakened science.
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Jeremy Berg @jeremymberg.bsky.social · 22/07/2026
New White House plan for science and technology released yesterday www.whitehouse.gov/releases/202... 1/9
whitehouse.gov
OSTP Director Releases Landmark Report and Recommendations for Renewing American Scientific Discovery
WASHINGTON, DC – Today, Assistant to the President and Director of the White House Office of Science and Technology Policy (OSTP) Michael Kratsios
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 22/07/2026
Sup Ct justices sometimes act as though they exist outside & above the Constitution, but ”That’s not true. They’re public servants, they’re part of our constitutional system, they’re part of checks and balances.” A roadmap for Supreme Court Term Limits⬇️ majorquestions.substack.com/p/want-supre...
majorquestions.substack.com
Want Supreme Court Term Limits? Here’s How to Do It
The Brennan Center has laid out a compelling roadmap for Congress to follow.
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 07/07/2026
How 2 explain Team USA’s sluggish play? The asshole-in-chief threw his weight around 2 bend the rules, & ended up with a dispirited team that got the message loud & clear that their president felt they needed special intervention. He ruins everything he touches. www.theguardian.com/commentisfre...
theguardian.com
Trump’s World Cup intervention has ruined the game | Robert Reich
We try to teach our children to follow the rules. Now an American president has chosen the opposite tack
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 02/07/2026
Last month, the CDC held a seminar focused on measuring vaccine effectiveness. Ben Lopman, a professor of epidemiology & global health, argues that this is part of a wider scheme by Trump admin leadership to manufacture a scientific debate where there isn't one.⬇️ www.statnews.com/2026/07/02/m...
statnews.com
CDC leadership continues to try manufacture a scientific debate on vaccines where none exists
CDC leadership continues to try manufacture a scientific debate on vaccines where none exists, writes Ben Lopman.
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 29/06/2026
I grew up idolizing Chris Evert’s astonishing concentration & baseline passing shots. (I sucked, but my Mum called me ‘little Chrissie’). Now I get to admire Chris’s tenacity in fighting ovary cancer, and the attention she brings to BRCA mutations & the importance of genetic testing. Go Chris!
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 26/06/2026
Dr Ralph Steinman had PDAC — & won a Nobel prize posthumously — just as J was diagnosed with pancreas cancer. We became avid readers of anything we could find about the promise of immunotherapy. The incredible story of the medical researcher who treated himself ⬇️ www.rockefeller.edu/news/1816-no...
rockefeller.edu
The Rockefeller University » Nobel laureate Ralph Steinman dies at 68
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 24/06/2026
Via pancan.org A Virtual Event - KRAS & PANCREATIC CANCER: A NEW ERA OF TREATMENT. Tomorrow! Thursday, June 25, 2026 | 11 a.m. PT | 2 p.m. ET. Register below ⬇️ pancan.org/facing-pancr...
pancan.org
KRAS and Pancreatic Cancer: Entering a New Era of Treatment - Thursday, 6/25
Join PanCAN on Thursday, June 25, at 11 a.m. PT / 2 p.m. ET, for a webinar focused on KRAS and pancreatic cancer. Our panel of special guests will talk about what KRAS is and why it’s important, the l...
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 22/06/2026
My kind of CONNECTIONS, quickly solved. Strictly word or symbol meanings, plus a little fun problem solving — pop culture knowledge not required! Connections Puzzle #1107 🟩🟩🟩🟩 🟪🟪🟪🟪 🟨🟨🟨🟨 🟦🟦🟦🟦
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 14/06/2026
They did it!! 🧡🔵🟠🔵🟠💙 No better illustration of tRump’s uncanny knack for screwing up everything he touches than the Knicks’ only loss in the 4-1 NBA Finals occurring when he upends & offends our entire town by attending game 3. They did it!! 💙🟠🔵🟠🔵🧡
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 11/06/2026
Infuriating. www.nytimes.com/2026/06/02/w...
nytimes.com
Hospitals See Diseases Resurge as Vaccinations Decline
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 06/06/2026
A helluva lot nicer than the Tang-colored octogenarian who wants to put his own scowling visage on American banknotes.
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 03/06/2026
Via Lustgarten.org, a webinar All about Daraxonrasib, a first-of-its-kind RAS-targeting therapy that demonstrated a near doubling of survival for patients with previously treated metastatic pancreatic cancer. JUNE 17 12:00 PM EDT. Register here! ⬇️ events.zoom.us/ev/AkDCv123Y...
events.zoom.us
A Deeper Dive into Our Understanding of Daraxonrasib
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 02/06/2026
Via pancan.org, a virtual event. KRAS AND PANCREATIC CANCER: A New Era Of Treatment Thursday, June 25, 2026 | 11 a.m. PT |2 p.m. ET Register here! pancan.org/facing-pancr...
pancan.org
KRAS and Pancreatic Cancer: Entering a New Era of Treatment - Thursday, 6/25
Join PanCAN on Thursday, June 25, at 11 a.m. PT / 2 p.m. ET, for a webinar focused on KRAS and pancreatic cancer. Our panel of special guests will talk about what KRAS is and why it’s important, the l...
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 01/06/2026
How is it that we are not TERRIFIED by a mad POTUS ranting in real time in the middle of the night & his finger on the nuclear codes? He is berserk, he is dangerous, & he is showing us his mental illness day & night. Dispirited some hosts at MSNOW play him 4 laughs as they share his maniacal posts.
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 31/05/2026
I’m sure Jack Schlossberg is a perfectly nice person, & he should take some of that quirky energy & put it to good use. But many of us are over the Kennedy coronation thing….as his mother Caroline learned during her short quest to be appointed to HRC’s senate seat. www.nytimes.com/2026/05/28/o...
nytimes.com
Opinion | He’s Entitled and Nepotistic. This Is Not What Democrats Need.
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Colette Delawalla, PhD @cdelawalla.bsky.social · 29/05/2026
- Political Appointees Take Control of Grant Awards (§200.205) - DEI, Gender Research, and Related Topics Banned as Grant Conditions (§200.300) - Peer Review Is No Longer Binding (§200.205(d)) - Applicants Can Be Denied Based on Organizational “Affiliations” (§200.206) 2/x
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 21/05/2026
Via NPR.org The tRump administration is finding new ways to punish science. Money approved by Congress is not reaching scientists at the rate it should be, & a lack of transparency at the NIH is compromising the integrity and reliability of research. www.npr.org/2026/05/21/n...
npr.org
Researchers say the Trump administration is finding new ways to punish science
Even with federal grants largely restored, scientists say the Trump administration is still preventing those funds from reaching them. The consequences, they say, are already becoming clear.
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 17/05/2026
Hard to reconcile the comments of Letai & Kennedy (X screenshot) with the reality of pediatric cancer funding as described in the NY Times. www.nytimes.com/2026/05/13/o...
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Sam Bagenstos @sbagen.bsky.social · 12/05/2026
RFK may have gone underground with it, but he's continuing to work aggressively to turn HHS against vaccines. Don't let the relative public silence fool you. www.nytimes.com/2026/05/11/h...
nytimes.com
Kennedy Is Driving a Vast Inquiry Into Vaccines, Despite His Public Silence
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 11/05/2026
Today, thousands of Nat Academies Science, Engineering, & Medicine members have signed & submitted an Open Letter to Congress demanding Trump restore the 22 National Science Board members he illegally fired on April 24th. Support by adding your name here ⬇️ www.standupforscience.net/nasem-letter...
standupforscience.net
NASEM Open Letter to Congress demanding the restoration of the NSB — STAND UP FOR SCIENCE
Support NASEM's open letter to Congress by signing your endorsement now!
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 10/05/2026
Via lustgarten.org Your Mother’s Day gift in support of pancreas cancer research will be doubled today! PDAC has a 5-yr survival rate of just 13%. Lustgarten drives research in 3 priority areas: early detection, personalized medicine, & therapeutics development. Donate ⬇️ lustgarten.org/mothersday/
lustgarten.org
Mother's Day Challenge
Join our Mother’s Day Matching Gift Challenge in support of the innovations that will one day transform pancreatic cancer into a curable disease.
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 10/05/2026
Profiteering, grift, corruption, graft. The tRump family has used the presidency to steal billions: crypto deals, government contracts, foreign influence & payments, upgrades to tRump properties, & pay to play. Is tracking this all we are doing about it?! oversightdemocrats.house.gov/trump-family...
oversightdemocrats.house.gov
Trump Family Digital Grift Wealth Tracker | The U.S. House Committee on Oversight
The Official U.S. Congressional website of The Democrat Oversight Committee
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 09/05/2026
Cancer cachexia a baffling aspect of J’s PDAC history. Post Whipple, he regained nearly all weight & we worked hard 2 maintain. For 6 yrs, success; last 2 yrs not. Scans continued 2 show stable disease whilst continuing chemo/parp inhibitor….yet profound weight loss www.medrxiv.org/content/10.6...
medrxiv.org
Anatomical dynamics define cancer cachexia subtypes and identify systemic inflammation as a marker of lethal wasting
Cancer cachexia is a wasting syndrome that remodels the anatomy of the patient. How this remodeling unfolds across tissues, whether it defines distinct disease states, and how these states relate to u...
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 05/05/2026
Immigration changes R driving foreign researchers to leave the U.S. - or not come at all. “International scholars will stay home," said Matthew Alexander, prof of pediatric neurology & genetics at the U of Alabama. "They'll stay in Europe and they'll stay in Asia." www.statnews.com/2026/05/04/t...
statnews.com
Immigration changes are driving foreign researchers to leave the U.S. — or not come to begin with
Labs are seeing fewer applications from international students and researchers, and some doctoral students are considering leaving early.
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 05/05/2026
Watching this dummy Pete Hegseth reminds me of the homicide detective character in Monk — Lt Disher — who inanely insists on giving names to his detecting endeavors (“We’ll call this ‘The Lipstick Killer’ Case”) while others are processing the crime scene.
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 04/05/2026
#11DayPowerPlay raises $ (>$11M since 2017) for cancer causes in WNY. 11DPP has >2,300 pairs of skates hitting the ice in 3-hr shifts in an 11-day hockey game! My bsky buddy‘s sons are participating⬇️ communityshift.11daypowerplay.com/AlexSmiraglia communityshift.11daypowerplay.com/ChristianSmi...
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 03/05/2026
tRump gutted US science by historic margins as it reduced the workforce at research agencies by tens of thousands & terminated grants. The admin also terminated >100 independent advisory panels comprising uni scientists who help guide science priorities. www.scientificamerican.com/article/key-...
scientificamerican.com
Key U.S. science panels are being axed—and others are becoming less open
A new analysis shows that the Trump administration has terminated more than 100 advisory committees to science agencies—and reduced the transparency and independence of those that remain.
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 01/05/2026
UPDATE (5/1/2026): The FDA has just authorized expanded access to daraxonrasib, a targeted therapy designed to treat KRAS-driven cancers. This treatment will now be available outside of clinical trials as a second-line option for pancreatic cancer patients. lustgarten.org/a-turning-po...
lustgarten.org
A Turning Point in Pancreatic Cancer: Daraxonrasib | Lustgarten Foundation: Pancreatic Cancer Research
UPDATE (5/1/2026): The FDA has just authorized expanded access to daraxonrasib, a targeted therapy designed to treat KRAS-driven cancers. For the first time, this treatment is now available outside of...
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 29/04/2026
My kind of CONNECTIONS today, where word meanings & usages take precedence over pop culture & other references that go right over my head. Fast & easy!
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Peter Girnus @gothburz.bsky.social · 23/04/2026
$2.1B in perfectly timed oil bets across five presidential announcements. Every one flagged. Every report filed. Zero prosecutions in fourteen years. I pulled the case files. gothburz.substack.com/p/i-flagged-...
gothburz.substack.com
I Flagged Every Trade
$2.1 billion in perfectly timed oil bets. Every report filed. Zero prosecutions.
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 23/04/2026
"I'm hopeful these treatments allow the disease to be incorporated into someone's life," says Dr. O'Reilly, "as opposed to their life being overtaken by the treatment of cancer."
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 23/04/2026
Tfw you order $75+ worth of cold meds (ok, includes 2 candy bars & a covid test) from your local pharmacy, you add a $15 tip, only to find a teeny bag w/the candy bars & a refund for the meds (not the tip) at your door. So now I still have to go out for what I needed, AND I paid a fortune for candy.
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 23/04/2026
Single-arm Phase 1b trial of patients with locally advanced PDAC. I hope this leads to further investigation in a Phase 2 trial. One notable outcome was that 23% of patients went on to achieve an RO resection.
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 22/04/2026
Fat chance, Columbia.
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Eric Topol @erictopol.bsky.social · 20/04/2026
Good summary of the marked benefit of the molecular glue drug (daraxonrasib) vs pancreatic cancer, from Revolution Medicines, and other progress (adds to the neoantigen vaccine with 6-year survival) gift link wsj.com/opinion/revo...
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EssJay PURPLE PURPOSE @purplepurpose.bsky.social · 20/04/2026
I have so many thoughts. As caregiver to my partner for 8 yrs, l took care of all, went to every treatment. His final 2 yrs were harrowing & I wanted a different life. But I was there for him, & now consider it my greatest demonstration of ❤️. messaging-custom-newsletters.nytimes.com/dynamic/rend...
messaging-custom-newsletters.nytimes.com
The Ethicist: My husband’s illness has me feeling trapped. Do I have to stay?
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