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Reposted by Vivek Anantharaman

Kumaran Ramamurthi @ramamurthilab.bsky.social · 15/09/2026

How do proteins localize in bacteria? Usually by binding to a prelocalized protein-but how does that protein localize? @vanipande.bsky.social found a #Bacillus subtilis protein that localizes via a lipid cue,undecaprenyl phosphate,that guides it to sites of PG synthesis www.pnas.org/doi/10.1073/...

pnas.org

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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Reposted by Vivek Anantharaman

Kumaran Ramamurthi @ramamurthilab.bsky.social · 06/08/2026

Biofilm formation in #Bacillus subtilis is thought to precede sporulation, but T. Updegrove says that a subpopulation of sporulating cells triggers other cells to become biofilm formers via an intracellular metabolite (glycerol) repurposed as a signaling molecule (!) www.science.org/doi/10.1126/...

science.org

A metabolite morphogen coordinates multicellular development in Bacillus subtilis

Cell-cell signaling using a core metabolite repurposed as a developmental cue coordinates bacterial multicellular development.

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Vivek Anantharaman @proteinverse.bsky.social · 22/08/2026

Biofilm formation and sporulation aren't sequential - they branch. In our new paper w/ @ramamurthilab.bsky.social , we show how sporulating B. subtilis repurposes glycerol as a morphogen to coordinate multicellular development: www.science.org/doi/full/10....

science.org

A metabolite morphogen coordinates multicellular development in Bacillus subtilis

Cell-cell signaling using a core metabolite repurposed as a developmental cue coordinates bacterial multicellular development.

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