Seva Viliuga @proteinator.bsky.social · 06/01/2026A proper way of commuting through piles of snow 🤣 020
Seva Viliuga @proteinator.bsky.social · 31/12/2025Biggest achievement of 2025 😂😂 First ever self-made cake seems to be a success!! 1111
Seva Viliuga @proteinator.bsky.social · 05/12/2025Had a great time presenting our work on flexibility-conditioned protein structure design at @embl.org and right after our recent work on generating conformational ensembles of proteins at @euripsconf.bsky.social together with Nico. Follow along - we will be soon releasing more exciting things :) 050
Seva Viliuga @proteinator.bsky.social · 17/07/20255/6 We introduce a framework in which we generate candidate protein structures conditioned on flexibility with FliPS and use BackFlip to select the candidates whose predicted flexibility profile best matches the target before running expensive MD simulations. 100
Seva Viliuga @proteinator.bsky.social · 17/07/20254/6 We also introduce BackFlip - an equivariant network that can accurately predict backbone flexibility as derived from MD simulations. Crucially, BackFlip infers flexibility solely from the backbone geometry without requiring evolutionary information, making it useful for de novo protein design. 110
Seva Viliuga @proteinator.bsky.social · 17/07/20253/6 In a series of experiments, we demonstrate that FliPS samples novel, realistic proteins with diverse secondary structure composition and a remarkable resemblance to custom target flexibility profiles, as verified in 300ns Molecular Dynamics (MD) simulations of the designed samples. 100
Seva Viliuga @proteinator.bsky.social · 17/07/20252/6 Our model FliPS is a conditional flow matching model for protein structure generation. FliPS receives a flexibility profile as conditional input feature and learns how to generate realistic protein structures while respecting target flexibilities. 100
Seva Viliuga @proteinator.bsky.social · 17/07/20251/6 One of the key features of functional proteins is their inherent structural flexibility. In our recent work at #ICML, we introduce flexibility to protein structure design! More in a thread below. Code / Tutorial: github.com/graeter-grou... Poster: W-109, Thu 17 Jul 11 a.m. PDT — 1:30 p.m. PDT 1228
Seva Viliuga @proteinator.bsky.social · 13/07/2025First time transatlantic and such a view over Greenland 🤯 Wish there were more glaciers :/ 000
Seva Viliuga @proteinator.bsky.social · 15/06/2025Attending conferences in Italy seems to be a great idea 🥸 020
Seva Viliuga @proteinator.bsky.social · 29/05/2025I finally won a lottery and got the CA visa?! Something must be wrong.. Guess that means me + ICML 2025! 😀 010
Seva Viliuga @proteinator.bsky.social · 23/03/2025Enjoyed a lot meeting all my old friends and listening to their great talks at Mosbacher Kolloquium this week! @leif-seute.bsky.social @maxfus.bsky.social 020
