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Amanda Randles 🧪⚛️ 👩‍🔬

@profamandarandles.bsky.social
3.7K followers 8.2K following 233 posts

Director of the Duke University Center for Computational and Digital Health Innovation. Professor of Biomedical Engineering. Research in HPC and digital twins for health.

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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 02/10/2026
❤️ Research in motion! We’re kicking off a regular look at images and animations from the Randles Lab. First up: a full-body blood flow simulation with HARVEY, exploring how blood moves through the body’s interconnected vessels. #RandlesLab #HARVEY
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 02/10/2026
📚 CCDHI CompHealth Corner: Could gut protection start before radiation exposure? A study co-authored by John Hickey found that blocking LATS1/2 before radiation promoted intestinal regeneration and improved survival in mice. duke.is/gut-radiatio...
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 30/09/2026
Five PhD milestones to celebrate in the Randles Lab! 🎉 We had so much to celebrate this semester that papers got their own party a few weeks ago. Yesterday was for milestones! Everyone gets a signed bottle, and I keep the cork with their initials. My box is filling up! So proud of this group!
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 30/09/2026
📚Meet featured researcher Hanting Ye of Duke’s I3T Lab! From an XR rehabilitation game for people with Parkinson’s disease to smart glasses for health monitoring, he’s exploring how technology could support people beyond the clinic. comphealth.duke.edu/featured-res...
comphealth.duke.edu
Featured Researcher: Hanting Ye - Center for Computational and Digital Health Innovation
Here’s what Hanting Ye, a Postdoctoral Associate in the Intelligent Interactive Internet of Things (I3T) Lab, is thinking about and working on.
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 25/09/2026
🧪Friday research image 🫀 This rotating pulmonary artery model is part of our work using HARVEY to create digital twins for noninvasive heart failure monitoring. Want to see more? Come meet the researchers at CCDHI Demo Day today, 3–6 PM in the Wilkinson Building!
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 25/09/2026
Today’s the day! 🎉 Join CCDHI Demo Day at Duke’s Wilkinson Building, 3–6 PM. Meet the Randles, Big IDEAs, I3T, Hickey, Grill, and Injury Biomechanics labs, plus Duke Innovation Co-Lab. Come see what the teams are building and chat with the people behind the work!
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 24/09/2026
Our software has a new look. We’ve updated the logos for HARVEY, HarVIS, and HarVI and would love your thoughts: do they feel connected while still giving each tool its own identity? Explore the updated software page: randleslab.pratt.duke.edu/research/har...
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 24/09/2026
How many red blood cells can we simulate at once? As we keep pushing that limit, we’re revisiting this image from earlier work by Ayman and Aristotle. Here, HARVEY simulates individual red blood cells moving through a complex vessel. #HARVEY #BloodFlow #RedBloodCells #ComputationalScience
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 23/09/2026
How can AI forecast a patient’s health from irregular clinical data? Join us today at 3 PM ET for a virtual CCDHI seminar with Duke’s Rishi Kamaleswaran, PhD, on multimodal data and clinical foundation models. Join here: duke.is/CompHealthSe...
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 22/09/2026
What’s next in digital health at Duke? Come see it in action. 👀 Join us for CCDHI Demo Day 2026—featuring live demos, hands-on tech, research posters, and work from labs across Duke. 📅 Sept. 25 | 3–6 PM 📍 Wilkinson Building Come curious. Leave connected.
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 21/09/2026
Our Fall newsletter is here! 🍂 Explore new digital health initiatives, student work on PULSE, recent awards, and upcoming events—including our September 25 Demo Day. Read it: comphealth.duke.edu/newsroom/new...
comphealth.duke.edu
Newsletter - Center for Computational and Digital Health Innovation
Newsletter Latest Issue Previous Issues
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 18/09/2026
🧪📚 Duke research pairs 1D blood flow modeling with machine learning to assess coronary disease noninvasively, achieving 92.6% accuracy in the test set. comphealth.duke.edu/publications...
comphealth.duke.edu
Optimizing Non-invasive Fractional Flow Reserve Estimation with Machine Learning-Enhanced 1D Hemodynamic Modeling - Center for Computational and Digital Health Innovation
Patient-specific computational models exhibit strong concordance with invasively measured fractional flow reserve (FFR)—the clinical gold standard for diagnosing coronary ischemia. However, current mo...
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 16/09/2026
Can foundation models forecast patient deterioration before it becomes visible? Join us September 23 for a Computational & Digital Health Seminar with Duke’s Rishi Kamaleswaran, PhD, on multimodal time-series models for predictive, whole-patient care. duke.is/CompHealthSept2026Seminar
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 15/09/2026
One of the best parts of leading CCDHI is seeing our amazing students thrive. I am so proud of undergraduate researcher Ella, along with Jorik and Ayman, for receiving an Outstanding Paper Award at IEEE HPEC 2026! 🏆 Thank you to Viridien for its collaboration and support.
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 12/09/2026
🧪📄 New paper! Simulations using advances in our adaptive physics refinement framework reveal how red blood cells influence circulating tumor cell trajectories and adhesion while reducing memory use by an order of magnitude. link.springer.com/article/10.1...
link.springer.com
An adaptive physics refinement framework to investigate red blood cells’ impact on adhesive tumor cell transport - Biomechanics and Modeling in Mechanobiology
Red blood cells play a dominant mechanical role in blood flow and strongly influence the transport and arrest of circulating tumor cells during metastasis. Circulating tumor cells (CTCs) are subject t...
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 11/09/2026
📚 CCDHI CompHealth Corner: Can math help design smarter cancer-fighting cells? A new Duke-led preprint, co-authored by CCDHI AD of Education Cameron Kim, models synNotch-CAR T cells to identify promising targets for more precise, controllable cancer therapies. www.biorxiv.org/content/10.6...
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 31/08/2026
The first-ever ACM AI Leadership Summit kicks off today in Atlanta! I’m giving a featured talk on AI & Scientific Discovery, and Nusrat Khan is presenting our work on coronary digital twins. Proud to have the Randles Lab represented at this inaugural summit!
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 28/08/2026
🧪📚 CCDHI CompHealth Corner — What are we reading this week? New in Nature Biotechnology: CCDHI Co-Associate Director of AI John Hickey and collaborators introduce a single-cell approach to uncover barriers to therapeutic antibody delivery in solid tumors. 🔗 duke.is/naturebiotech
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 26/08/2026
🧪It was great talking with fellow Duke alum Katy Hansell about the future of digital twins and what they could mean for proactive healthcare. We covered HARVEY, AI, wearables, and where this technology is headed. Watch here: www.youtube.com/watch?v=B4RL...
youtube.com
The Future of Medicine: How Digital Twins Can Predict Your Health
YouTube video by Katy Hansell: The Impact Whisperer® podcast
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 26/08/2026
Big week in the Randles Lab! 🎉 We’re back for a new semester and already celebrating: Guinevere Ferreira and Jorik Stoop both passed their preliminary exams and are officially PhD candidates! So proud of them both and excited for what comes next. 🥂🎓
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 21/08/2026
One of the best parts of running a lab: celebrating students! 🥂 This week: Guin’s first first-author paper + Wendy’s first first-author and first top-tier paper! Our tradition: everyone signs the champagne bottle, they keep it & I keep the cork. 🍾 What does your lab do?
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 14/08/2026
Our vascular digital twin work is moving toward a bigger goal: understanding not just a patient’s cardiovascular health today, but where it is heading. Thanks to Cardiovascular Business for highlighting our work toward proactive, personalized care. cardiovascularbusiness.com/topics/patie...
cardiovascularbusiness.com
Duke's digital twin technology could take hemodynamic assessments to a whole other level
Researchers at Duke are hard at work on digital twins that could help care teams make important treatment decisions.
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 14/08/2026
🧪What keeps antibody therapies from reaching cancer cells? A new @NatureBiotech study co-authored by CCDHI Co-Associate Director of AI John Hickey maps drug delivery at single-cell resolution, revealing stromal barriers that may limit treatment. #CancerResearch #CompHealth
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 13/08/2026
🧪 Almost 20 years ago, I realized I didn’t just want to build supercomputers. I wanted to use them to solve problems that mattered. Great to talk with TheScientist about that journey and our work using HARVEY to build vascular digital twins. www.the-scientist.com/digital-twin... #DigitalTwins #HPC
the-scientist.com
Digital Twins Modeling Blood Flow Could Predict Heart Problems | The Scientist
The HARVEY platform leverages supercomputing, physics-based simulations, and wearable device data to monitor real-time hemodynamics and spot heart failure early.
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 07/08/2026
🧪📚 Can virtual reality help patients recover in the ICU? New research from CCDHI Associate Director of XR Maria Gorlatova’s lab explores a VR exergame for engaging, measurable, patient-centered rehabilitation in critical care. Read more: duke.is/VRgame #VirtualReality #DigitalHealth #XR
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 03/08/2026
How do you simulate cellular interactions at physiologically relevant scales? R&D World highlights our research on Adaptive Physics Refinement, a framework that preserves cellular detail where it matters most while enabling larger vascular simulations. duke.is/rdworld #HPC #CancerResearch
duke.is
How a Duke-led HPC method improved cell-scale cancer simulation
Researchers at Duke University created a physics-based technique that can capture a how a cancer cell moves through a blood vessel.
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 03/08/2026
For decades, computational models have helped explain experimental observations. My latest guest column in Drug Discovery Online explores how computational mechanics is changing drug discovery: duke.is/ddo #DrugDiscovery #HPC
duke.is
The Changing Role Of Computational Mechanics In Drug Discovery
Computational models will never replace experimental biology, but their emerging role is different.
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 03/08/2026
Our inaugural CCDHI Code+ team wrapped up an incredible summer! Together with Duke OIT, they helped build PULSE, our new wearable research platform. Coming soon: fitness tracking, Duke Rec integration, PulsePets, and more. Huge thanks to Alexis, Steven, and an amazing student team!
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 31/07/2026
🧪📚 CCDHI CompHealth Corner: Can we better predict stroke risk in atrial fibrillation? A new study from researchers including CCDHI's Schuyler Jones and Manesh Patel shows that adding routine clinical data to standard risk scores significantly improves prediction of stroke and major bleeding.
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 28/07/2026
Excited for #PEARC2026 in Minneapolis! I'll be giving Tuesday's keynote on how HPC is enabling trajectory-based science and digital twins for personalized healthcare. I'm also looking forward to meeting students interested in HPC, AI, and biomedical engineering!
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 27/07/2026
🧪Making cardiovascular digital twins more accessible starts with reducing reliance on invasive pressure measurements. Randles Lab BME PhD student Guinevere Ferreira will present her latest work on pressure scaling for cardiovascular digital twins at #EMBC2026 on Wednesday. Join us!
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 17/07/2026
From K-ville to Full Professor. I came to Duke as an undergraduate, left for a few years, and was fortunate to return as faculty. Grateful to the mentors, trainees, colleagues, collaborators, and family who have supported me throughout this journey.
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 13/07/2026
This week's CompHealth Corner highlights our latest work on APR-AD. Proud of this collaboration with Aristotle Martin, William Ladd, and Runxin Wu, advancing tissue-scale simulations of circulating tumor cells and cancer transport. Paper: comphealth.duke.edu/publications...
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 09/07/2026
Excited to share our new perspective in IEEE Computing in Science & Engineering! Co-authored with Ewa Deelman, Jack Dongarra, Bruce Hendrickson, Daniel Reed, Edward Seidel, and Katherine Yelick, we revisit the Lax Report and the future of HPC. www.computer.org/csdl/magazin...
computer.org
CSDL | IEEE Computer Society
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 03/07/2026
🧪 Pleased to have authored the accompanying editorial in the New England Journal of Medicine discussing the scientific foundations behind two clinical trials evaluating computationally enabled physiological assessment for coronary artery disease. duke.is/nejm
duke.is
Physiological Assessment of Coronary Artery Disease | NEJM
The author describes the scientific foundations of two trials comparing how noninvasive and invasive assessments of fractional flow reserve affect clinical outcomes.
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 29/06/2026
Busy week for the Randles Lab! After presenting at ICCS 2026, Ayman Yousef is heading to PASC 2026 to present our paper, GPU Halo Replay, by Ayman Yousef, Aristotle Martin, and Amanda Randles. If you're at PASC, stop by and say hello! #PASC2026 #HPC #RandlesLab
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 29/06/2026
The Randles Lab is heading to Hamburg for ICCS 2026! We'll be presenting research on longitudinal cardiovascular digital twins, AI-enabled HPC simulation workflows, and multiscale cancer modeling. Looking forward to great discussions—come say hello if you're attending! #ICCS2026 #HPC #DigitalTwins
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 26/06/2026
One of my favorite sessions at #ISC2026 was on AI and the HPC-edge continuum in digital twin workflows with Peter Coveney and Anuj Kapadia. Digital twins aren't just simulation problems. They're workflow problems requiring VVUQ, data management, orchestration, provenance, automation, and physics.
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 26/06/2026
Excited to speak today at #ISC2026's A2SD Workshop! I'll be presenting "Chronophysiomics: Autonomous Discovery Through Longitudinal Digital Twins," exploring how AI, HPC, wearable data, and physics-based simulation can enable trustworthy autonomous scientific discovery and predictive healthcare.
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 23/06/2026
Weather forecasting transformed how we respond to storms. What if we could do the same for human health? Looking forward to my #ISC26 keynote on HPC for vascular digital twins, chronophysiomics, and the path toward forecasting disease before symptoms appear.
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 23/06/2026
Loved discussing how HPC and AI are helping make healthcare digital twins a reality. From modeling blood flow in patient-specific vascular networks to studying physiology across millions of heartbeats, we're working toward proactive healthcare. www.scientific-computing.com/article/scw7...
scientific-computing.com
The SCW75 Q&A: Building digital twins of human physiology | Scientific Computing World
Amanda Randles discusses building patient-specific digital twins that could transform disease prediction, prevention and personalised healthcare
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 22/06/2026
Wentao Ma and I (Duke U), with Xuning Zhao and Mauro Rodriguez Jr. (Brown U), are co-organizing the mini-symposium “Computational Hemodynamics and Cardiovascular Mechanics” at the USNC-TAM26. Dr. Ma will present new work on scalable cardiovascular flow simulation in compliant vessels.
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 13/06/2026
Congratulations to Randles Lab Ph.D. student Nusrat Sadia Khan on receiving Duke University's Outstanding Teaching Assistant Award! 🎉 Recognized for her exceptional teaching, mentorship, and dedication to student success in BME 307: Transport Phenomena in Biological Systems. #DukeBME
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 13/06/2026
📚 CompHealth Corner A new Lancet Digital Health Viewpoint co-authored by CCDHI Associate Director of Wearables Jessilyn Dunn explores health data commercialization, transparency, privacy, and patient trust. An important read for responsible digital health. comphealth.duke.edu/publications...
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 05/06/2026
📚 CCDHI CompHealth Corner How small are epilepsy-related brain signals? Researchers, including CCDHI members Jonathan Viventi and Gregory B. Cogan, found high-density microelectrodes detected 14× more HFOs, with 93% missed by standard electrodes. comphealth.duke.edu/publications...
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 28/05/2026
Honored to be recognized as part of the inaugural SCW75 by Scientific Computing World — celebrating leaders shaping the future of scientific computing across HPC, AI, simulation and research infrastructure. #SCW75 #ScientificComputing #HPC #AI #ResearchComputing #Simulation
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 26/05/2026
📚 CCDHI CompHealth Corner: A new study from Jessilyn Dunn’s lab, published in Nature Health, used Fitbit + All of Us data to study daylight saving time. The work highlighted how wearable data can reveal impacts of public policy on behavior. → Read more: comphealth.duke.edu/publications...
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 22/05/2026
📚 CCDHI CompHealth Corner this week features our review on circulatory digital twins in Nature Reviews Bioengineering. Read more: comphealth.duke.edu/publications...
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 15/05/2026
CCDHI Graduate Highlight 🎓 Celebrating Sarah Eom and her work in AR, IoT, and healthcare innovation from Duke to Exponent. 💙
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Amanda Randles 🧪⚛️ 👩‍🔬 @profamandarandles.bsky.social · 14/05/2026
Celebrating Perisa Ashar from the Duke Center for Computational and Digital Health Innovation and @drjessilyn.bsky.social ’s BIG IDEAs Lab. NSF GRFP → Georgia Tech 🎓💙
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