https://pubmed.ncbi.nlm.nih.gov/42818647/?utm_source=Chrome&utm_medium=rss&utm_campaign=pubmed-2&utm_content=12GmDGiSiGA9an3uAk7xg5WeD6SUYkvXu9hh-tydPALMY8vQtD&fc=20241229120800&ff=20261001125438&v=2.20.1

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Beacon lights path to FDA approval with pivotal trial win for rare vision loss gene therapy

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AbbVie-backed ADARx plans IPO to bankroll array of clinical-stage siRNA therapies

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Danicopan for Geographic Atrophy Secondary to Age-Related Macular Degeneration: Results From the Phase 2 Randomized OnwarD Trial

Editor’s Corner: Why an AstraZeneca-Bristol Myers Squibb merger is a bad idea

Moss-derived recombinant Factor H, CPV-104, effectively antagonizes alternative pathway C3/C5 convertases stabilization by NeFs from patients with primary C3 glomerulopathy - PubMed

Jasper finds new purpose in merger with Kira, while offloading Tavneos rival to Mirador

House passes bill directing FDA to update animal testing rules

Restoration of impaired lysosomal function mitigates drusen-like deposit formation and cell death in Malattia Leventinese - PubMed

J&J axes eye disease gene therapy after key phase 2b readout

Association of FHR5 With Disease Severity in ANCA-Associated Vasculitis - PubMed

Exogenous mitochondrial transplantation attenuates oxidative stress-driven retinal degeneration in a sodium iodate - induced mouse model - PubMed

ApoE- and Cfh-deficient mice exhibit structural and molecular features of human early-intermediate retinal degeneration - PubMed

Avacincaptad Pegol Slows Progressive Ellipsoid Zone Degradation/Loss in Eyes With Geographic Atrophy - PubMed

Pharmacological Characterization of a Novel Complement C3 Inhibitor Antibody Fragment - PubMed

Choriocapillaris Flow Deficits Are Spatially Linked to Retinal Pigment Epithelium and Photoreceptor Integrity in Geographic Atrophy - PubMed

OCT-based AI-assisted phenotyping of intermediate AMD in the prospective PINNACLE trial: PINNACLE Study Report 9 - PubMed

US Retina Specialists' Preferences for Geographic Atrophy Treatment - PubMed

Development of a conceptual, HOV-inspired spatial weighting model for quantifying geographic atrophy severity - PubMed

Decoding the Factor H‐Related Proteins: Gatekeepers of Complement Dysregulation in AMD

Complement-Modulating Mechanisms of Ginkgo biloba Extract in Dry AMD: Insights From Molecular Docking and Dynamics Simulations - PubMed

Tissue-resident macrophages maintain choroidal homeostasis by complement dependent and independent mechanisms - PubMed

Geographic Atrophy in Patients with Age-Related Macular Degeneration Is Associated with Rare Variants in Complement Factor H and Complement Factor I - PubMed

Paired DNA and RNA sequencing uncovers common and rare variation regulating human retinal gene expression

Efficacy of Continuous Pegcetacoplan Treatment for Subfoveal Geographic Atrophy in Age-Related Macular Degeneration: 36-Month Results from OAKS, DERBY, and GALE Open-Label Extension - PubMed

Development of a humanized anti-fibrin monoclonal antibody for the treatment of neuroinflammatory and retinal diseases - PubMed

Visual noise in augmented reality improves vision in age-related macular degeneration - PubMed

Ray Therapeutics shines a light on $125M round targeting genetic eye therapy

Complement Factor H as a Novel Predictive Biomarker for Deep Vein Thrombosis Recurrence: A Prospective Cohort Study - PubMed

Single-Cell Gene Expression and eQTL Analyses in the Human Retina, RPE, and Choroid in Macular Degeneration - PubMed

Human retinal organoid model of disease-relevant photoreceptor cell death amenable to drug screening - PubMed

FDA urges clinical trial sponsors to report the results of their studies

Discovery of (3 R,4 R)-15: An Advanced Factor B Inhibitor Entering Phase 3 for Complement-Mediated Diseases - PubMed

Dual Role of Factor H-Related Protein 1 in IgA Nephropathy Kidney Injury - PubMed

Metabolic vulnerability index and MetaboHealth score as risk factors for age-related macular degeneration in a large-scale prospective cohort - PubMed

Artificial Intelligence-based characterization of therapeutic response in fluid types and volumes influencing retinal function in neovascular age-related macular degeneration - PubMed

Complement regulatory proteins are associated with progression rate of geographic atrophy secondary to age-related macular degeneration - PubMed

Distinct Genetic Profiles Associated With Subretinal Drusenoid Deposits and Cardiovascular Risk in Age-Related Macular Degeneration - PubMed