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#SingleCell preprints

@prepub-singlecell.bsky.social
746 followers 1 following 7.5K posts

feeds: biorxiv, medrxiv, arxiv.q-bio, arxiv.cs, arxiv.math, Research Square regex: '(single(- )(cell|nuclei)|s[cn]RNA-seq)' If you have suggestions, please get in contact with @willmacnair :)

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#SingleCell preprints @prepub-singlecell.bsky.social · 1h
The RNA helicase KREH2 directly binds the RESC1-RESC2 complex in trypanosomatid mitochondrial RNA editing #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 1h
An amyloid-β/APP regulatory layer in human brown adipocyte recruitment identifies repurposable drugs for thermogenic fat expansion #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 1h
A regenerative fibroblast competence field supports multiple cell fates in adult skin regeneration #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 1h
BRN2 suppresses stress-induced hair greying #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 1h
Epigenetic regulators partition the genome by evolutionary and developmental constraint #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 1h
EndoMT: An R Package Resource for Endothelial-Mesenchymal Transition Gene Set Enrichment Analysis #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 1h
methylTFR: Computational quantification of transcription factor activity from DNA methylation #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 4h
Construction of a Prognostic Model for Pancreatic Cancer Based on mitochondrial dynamics-Related Genes: Application of Multiple Machine Learning Methods #SingleCell 🧪🧬🖥️ www.researchsquare.com/article/rs-1…
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#SingleCell preprints @prepub-singlecell.bsky.social · 4h
KIF3A as a transcriptomic marker of ciliation status in human striatal parvalbumin interneurons: single-cell evidence linking intraflagellar transport to the LRRK2-Rab-ciliogenesis axis #SingleCell 🧪🧬🖥️ www.researchsquare.com/article/rs-1…
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#SingleCell preprints @prepub-singlecell.bsky.social · 4h
Single-Cell Multiplex Immune Biomarker Prediction from Histopathology Across Cancer Types and Clinical Endpoints #SingleCell 🧪🧬🖥️ www.researchsquare.com/article/rs-1…
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#SingleCell preprints @prepub-singlecell.bsky.social · 4h
Introducing Nanoscale Dynamic Force Spectroscopy to Resolve the States of Live Cells #SingleCell 🧪🧬🖥️ www.researchsquare.com/article/rs-1…
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#SingleCell preprints @prepub-singlecell.bsky.social · 10h
Integrated single-cell transcriptomic analysis reveals KLF6-associated macrophage-alveolar epithelial crosstalk in sepsis-associated acute lung injury #SingleCell 🧪🧬🖥️ www.researchsquare.com/article/rs-1…
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#SingleCell preprints @prepub-singlecell.bsky.social · 16h
PerturbCellRL: Aligning Distributions and Grounding Biology via Post-Training Perturbation Generators #SingleCell 🧪🧬🖥️ arxiv.org/abs/2606.27752
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#SingleCell preprints @prepub-singlecell.bsky.social · 16h
Simulation-Free Learning of Population Dynamics with Wasserstein Lagrangian Residuals #SingleCell 🧪🧬🖥️ arxiv.org/abs/2610.03679
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#SingleCell preprints @prepub-singlecell.bsky.social · 16h
Quantifying reticulocyte biomechanics in health and disease #SingleCell 🧪🧬🖥️ arxiv.org/abs/2607.21810
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#SingleCell preprints @prepub-singlecell.bsky.social · 16h
Generalizable single-cell perturbation response prediction using energy-guided flow matching #SingleCell 🧪🧬🖥️ arxiv.org/abs/2610.02232
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#SingleCell preprints @prepub-singlecell.bsky.social · 04/10/2026
Development and Validation of a Machine Learning–Based Cell Death– Immune Prognostic Model for Risk Stratification in Diffuse Large B-cell Lymphoma #SingleCell 🧪🧬🖥️ www.researchsquare.com/article/rs-1…
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
Method-dependent biases in cell type detection between single-cell and single-nucleus RNA sequencing in the photosymbiotic acoel Praesagittifera naikaiensis #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
Low-Density Lipoprotein Cholesterol and Cerebral Pericyte Dysfunction in Acute Ischemic Stroke: Clinical and Experimental Evidence #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
Corallimorpharian genome supports the monophyly of Scleractinia and illuminates the cellular evolution of coral calcification #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
Topoisomerase-mediated resolution of negative DNA supercoiling sustains human transcription and gene activation #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
RasGRP1 promotes efficient intestinal tuft cell differentiation #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
Spatially coordinated RTK-ERK signaling dynamics shape osteosarcoma single-cell drug response in the lung microenvironment #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
Population reweighting and reporter distortion obscure ribosome regulation during translation inhibition #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
Extracellular cGAMP transmission exacerbates neuroinflammation in aging and multiple sclerosis #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
Clonally expanded CD8 T cells in AML adopt an NK-like program distinct from canonical exhaustion #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
SCITRAM: a Single-cell Integrated transcription regulation modeler for predicting master transcription factors #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
RecBCD Prevents Bacterial Autoimmunity by Clearing Self-DNA Ends Produced During Replication Termination #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
scTrilemma: Balancing Identity, Invariance, and Fidelity in Single-Cell Representation Learning #SingleCell 🧪🧬🖥️ arxiv.org/abs/2609.38840
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
When Do Biological Reasoning Models Use Their Biological Inputs? #SingleCell 🧪🧬🖥️ arxiv.org/abs/2610.00898
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
A Shared Taste for Model-Written Text: The Generator-by-Selector Matrices of "AI-AI Bias" Show No Detectable Own-Model Premium #SingleCell 🧪🧬🖥️ arxiv.org/abs/2610.00369
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
Exponential quantum advantage in processing massive classical data #SingleCell 🧪🧬🖥️ arxiv.org/abs/2604.07639
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
Pheno-GS: Phenoscape-scale Geodesic Sinkhorn #SingleCell 🧪🧬🖥️ arxiv.org/abs/2609.27633
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
Diagnostic and Prognostic Gene Signatures Linking Endoplasmic Reticulum Stress and Metabolic Reprogramming in Colon Cancer #SingleCell 🧪🧬🖥️ www.researchsquare.com/article/rs-1…
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
Computational aberration-corrected volumetric imaging of single retinal cell dynamics in the living eye #SingleCell 🧪🧬🖥️ www.researchsquare.com/article/rs-1…
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
Astrocytic coactivation of Wnt beta catenin and pyroptosis pathways in neuropathic pain with human genetic evidence and drug prioritization #SingleCell 🧪🧬🖥️ www.researchsquare.com/article/rs-1…
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
A transcriptomic readout of chromosomal instability reveals genome-stress states beyond proliferation in colorectal cancer #SingleCell 🧪🧬🖥️ www.researchsquare.com/article/rs-1…
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
Exploration of N7-methylguanosine and immune-related biomarkers in Acute Aortic Dissection by combining bulk RNA-seq sequencing data and single-cell RNA sequencing #SingleCell 🧪🧬🖥️ www.researchsquare.com/article/rs-1…
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
Rank-Preserving Alignment Enables Cross-platform Learning and Phenotyping for Single-Cell and Spatial Proteomics #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 02/10/2026
Genetic risk and inflammatory signaling converge on cell type-specific regulatory programs in type 1 diabetes #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 01/10/2026
Diabetes related antibody signature highlights ZnT8 as a novel antigenic target in rheumatoid arthritis #SingleCell 🧪🧬🖥️ www.medrxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 01/10/2026
Nuclear acetyl-CoA accumulation drives reversible RBP hyperacetylation and transcriptome-wide splicing shifts in age-equivalent Alzheimer's disease neurons #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 01/10/2026
Limitations of differential expression for cell-type marker discovery in single-cell RNA sequencing atlases #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 01/10/2026
Cerebral organoids recapitulate interneuron chain migration in the human cortex #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 01/10/2026
TET loss of function selects for aneuploidies that confer a proliferative advantage #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 01/10/2026
A Metacell Model of Single Cell RNA-seq Counts Yields a Gaussian Mixture Model in PCA Space #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 01/10/2026
Systems-level multi-omics integration identifies a survival-linked myeloid program in pancreatic ductal adenocarcinoma #SingleCell 🧪🧬🖥️ www.researchsquare.com/article/rs-1…
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#SingleCell preprints @prepub-singlecell.bsky.social · 01/10/2026
Stressed alga-free coral cells can initiate coral bleaching #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 01/10/2026
Early dynamics of a neutrophil interferon program drive immunotherapy resistance and limit durable anti-tumor immunity #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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#SingleCell preprints @prepub-singlecell.bsky.social · 01/10/2026
Multi-Model Machine Learning Consensus Identifies a Dual-Interferon Gene Signature in Ischemic Stroke: An Integrative Single-Cell Transcriptomic Analysis #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
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