iiinova — where your digital self keeps evolving

Davit Potoyan

@potoyan.bsky.social

262 followers 165 following 3 posts

We are a curiosity-driven theoretical/computational biophysics lab at Iowa State University. Interested in biomolecular condensates, allostery, gene regulatory networks, chromatin, the origin of life, and RNA functions

Posts Replies Media

Davit Potoyan @potoyan.bsky.social · 04/11/2025

Our RNA condensate work is finally out! Using simulations, we uncover the origin of the lower critical solution temperature (LCST) behaviour underlying thermo, iono-sensing functions in pure RNA condensates. www.pnas.org/doi/10.1073/...

092

Davit Potoyan @potoyan.bsky.social · 24/02/2025

A new paper shows how LCD sequence patterns encode condensate dynamics and material properties. 🔹 Periodic repeats → Elasticity-dominated 🔹 Disordered sequences → Viscosity-dominated 🔹 Minimum sticker spacing is crucial for fluidity, preventing transitions to glassy states. doi.org/10.1371/jour...

072

Davit Potoyan @potoyan.bsky.social · 06/12/2024

In collaboration with @priya-r-banerjee.bsky.social we dive a little deeper into the microscopic interactions and sequence patterns that are shaping condensate activation energies pubs.acs.org/doi/10.1021/... For more context see also our prior work www.science.org/doi/10.1126/...

041