In IgA nephropathy, dapagliflozin slowed eGFR decline, especially in patients with faster pre-treatment loss. The pre-treatment eGFR slope predicted post-treatment benefit, suggesting value in guiding therapy.
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Pre-treatment GFR slopes predict dapagliflozin response in IgA nephropathy
Dapagliflozin exerts renoprotective effects in patients with IgA nephropathy (IgAN).
However, the association between the pre-treatment estimated glomerular filtration
rate (eGFR) slope and post-treat...