iiinova — where your digital self keeps evolving

Paola A. Marignani @pmarignani.bsky.social · 04/10/2026

At 5 am I decided to make gnocchi, but first had to make sugo. 6 hours later, gnocchi. All good.

Paola A. Marignani @pmarignani.bsky.social · 30/09/2026

You are very much alive. What amazing stories of how research was conducted and how we really have so much more to discover. I particularly like the first step in protein purification😳. Old school

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Paola A. Marignani @pmarignani.bsky.social · 30/09/2026

Excited to share Episode 1 of my podcast Precision Science. Episodes will include scientists, patient advocates, healthcare professionals and more. Please that for my first episode, I interviewed the legend @jwoodgett.bsky.social Enjoy. youtube.com/watch?v=18Cf...

youtube.com

Precision Science - Ep 1 - Jim Woodgett

YouTube video by Precision Science

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Paola A. Marignani @pmarignani.bsky.social · 07/09/2026

It's that time of the year when students apply to Professors for MSc, PhD or PDF mentorship. Great! Tip: Please remember to state in your email, where you received your undergraduate or graduate degrees, country & year. Be unique. Stand out.

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Paola A. Marignani @pmarignani.bsky.social · 01/09/2026

Wow. Halifax is glowing tonight. Makes grant writing more enjoyable.

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Reposted by Paola A. Marignani

American Society of Clinical Oncology @ascocancer.bsky.social · 14/08/2026

Attn. senior investigators! @conquercancer.bsky.social is accepting LOI’s for the Research Professorship in Ovarian Cancer. This award provides flexible funding to full professors dedicated to training the next generation of oncology leaders. LOIs due Sept. 23: bit.ly/45lusff

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Paola A. Marignani @pmarignani.bsky.social · 28/06/2026

❤️🇨🇦🇨🇦🇨🇦🇨🇦🇨🇦⚽

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Paola A. Marignani @pmarignani.bsky.social · 25/06/2026

This level of energy input is not for the weak.

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Reposted by Paola A. Marignani

LKB1 (STK11) @stk11.bsky.social · 22/06/2026

LKB1 loss suppresses estrogen, progesterone, and androgen signalling pathways, and that HLA-DRB5 is consistently downregulated across all STK11-mutated subtypes, suggesting an immune evasion component. A lot going on beyond the canonical AMPK-mTOR axis.

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Paola A. Marignani @pmarignani.bsky.social · 22/06/2026

Preprint from marignanilab.com. LKB1 isn't just a tumour suppressor kinase with metabolic function; there's more😁. We used scRNAseq, CRISPR, patient tumours, METABRIC genomics & new mouse model to ask:what is the impact of losing LKB1 expression on breast cancer? www.biorxiv.org/content/10.6...

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Paola A. Marignani @pmarignani.bsky.social · 20/06/2026

.....perfect balance of protein, lipids and carbs! #bibimbap

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Paola A. Marignani @pmarignani.bsky.social · 19/06/2026

🌤️☕👩🏻‍💻 Spatial distribution of the proteome in the human body and in cancers. The authors present a comprehensive human proteomic landscape, by profiling>13,000 proteins across 2,856 samples. Dataset spans 58 major tissue types, 251 specific tissue subtypes and 25 distinct carcinomas. t.co/GxtrlhTjMb

t.co

https://www.nature.com/articles/s41586-026-10660-y

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Paola A. Marignani @pmarignani.bsky.social · 17/05/2026

....slowly easing back into climbing....very slow. Just getting here took some time. Goal: climb midway with controlled descent. Aim1. Put climbing shoes on Aim2. Chalk up hands Aim3. Just do it.

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Paola A. Marignani @pmarignani.bsky.social · 07/05/2026

There is still time to register for Hot Topics in Basic and Translational Science @iaslc.bsky.social in Dublin, Ireland, June 26-27, 2026! ht26-iaslc.eventsair.site

ht26-iaslc.eventsair.site

Home

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Paola A. Marignani @pmarignani.bsky.social · 04/05/2026

I am deeply honoured to receive the Alumni of Distinction Award for Excellence in Basic Science Research, Schulich School of Medicine and Dentistry 2026- Western University www.schulich.uwo.ca/about/news-e...

schulich.uwo.ca

Alumni of Distinction Awards celebrate impact and leadership - Schulich School of Medicine & Dentistry - Western University

This year’s six honourees exemplify excellence, with meaningful contributions across their professions and communities.

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Paola A. Marignani @pmarignani.bsky.social · 25/04/2026

Today, April 25th, my family commemorates Festa della Liberazione. 🇮🇹 1945, the Italian Resistance, and Allied forces, liberated Italia from fascist dictatorship and Nazi occupation. We honor the courage of the Marchigiani partigiani who fought for the liberty Italy enjoys tod #25Aprile #Italy

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Paola A. Marignani @pmarignani.bsky.social · 11/04/2026

Welcome back Earthlings👽😁🧑🏻‍🚀👨🏾‍🚀👨🏻‍🚀👨🏻‍🚀🚀🛸🌑

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Paola A. Marignani @pmarignani.bsky.social · 06/04/2026

🌞☕👩🏻‍💻 Landscape and functional impact of variants of unknown significance of immune response genes in human cancer. www.linkedin.com/safety/go/?u...

linkedin.com

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Reposted by Paola A. Marignani

Canadian Women in STEM @cdnwomenstem.bsky.social · 02/04/2026

#ChristinaKoch, first #Woman in history to the moon. Talk about breaking barriers. @cdnwomenstem.bsky.social #CDNWomenSTEM congratulates the little girl that had a big dream and the woman that fulfilled that dream. #STEMWomen #LeadByLifting 🚀🌘👩🏻‍🚀🫰🏻

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Paola A. Marignani @pmarignani.bsky.social · 01/04/2026

🚀 History is happening. For the 1st time in 53yrs, humans are on their way to the Moon. NASA's #ArtemisII crew; Commander Reid Wiseman, Pilot Victor Glover, Mission Specialist Christina Koch, and 🇨🇦 astronaut Jeremy Hansen have lifted off aboard the Orion #NASA #Artemis #SpaceExploration #Moon

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Paola A. Marignani @pmarignani.bsky.social · 27/03/2026

There is always room for Bibimbap.

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Paola A. Marignani @pmarignani.bsky.social · 27/03/2026

Also allows one to tailor the CV for each different grant application submitted. Important/relevant information specific to that grant application.

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Paola A. Marignani @pmarignani.bsky.social · 10/03/2026

What do Signal Transduction, Neural Networks, Artificial Intelligence and Agentics, all have in common? COMMUNICATION. Join us at @dalhousie.bsky.social for an afternoon of science, technology and Guglielmo Marconi. events.dal.ca/medicine/eve...

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Paola A. Marignani @pmarignani.bsky.social · 09/03/2026

Please join us on March 11th to celebrate the Evolution of Communication: Marconi to Agentic AI. Faculty of Medicine,Tupper Medical Bldg,Theatre A,4pm. Welcome Italian Ambassador to Canada H.E Alessandro Cattaneo to @dalhousieu.bsky.social @dalhousie.bsky.social 🇨🇦🇮🇹 Open to our Halifax community.

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Paola A. Marignani @pmarignani.bsky.social · 08/03/2026

Happy International Women's Day! Today, I am celebrating the incredible strength, resilience, and achievements of women that lift me. In a world facing instability, it's women and girls who are often most affected, facing increased risks and deeper inequalities. #InternationalWomensDay #IWD2026

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Paola A. Marignani @pmarignani.bsky.social · 05/03/2026

At the end of the day.....of CIHR grant submission. 🎻

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Paola A. Marignani @pmarignani.bsky.social · 04/03/2026

❄️☕👩🏻‍💻 🧐SCC demonstrates sensitivity with immunochemotherapy, but non-SCC, especially with KRAS+KEAP1/STK11 co-mutations, represents a distinct, immune-cold, high-risk subtype. www.jto.org/article/S155...

jto.org

Neoadjuvant Immunochemotherapy in Resectable NSCLC With SMARCA4 Alterations

Neoadjuvant immunochemotherapy has improved pathologic complete response (pCR) rates and event-free survival in resectable NSCLC, yet its efficacy in SMARCA4-altered NSCLC, a subset associated with po...

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Paola A. Marignani @pmarignani.bsky.social · 17/02/2026

Am I the only one that becomes obsessed with #Olympic 🥌? Riveting at 5 am!!

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Paola A. Marignani @pmarignani.bsky.social · 15/02/2026

Ravi, what features form the basis of the algorithm? Margins, grammar?? And do you know if your discoveries that firm the basis of your grant (ideas, innovations, prelim data) are now part of the "cloud" and are being mined by others? How about the pre-lim data? Just curious.

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Paola A. Marignani @pmarignani.bsky.social · 15/02/2026

Today is National Flag of Canada Day. At the stroke of noon on February 15, 1965, Canada's red and white maple leaf flag was raised for the very first time on Parliament Hill. 🇨🇦🇨🇦🇨🇦🇨🇦🇨🇦🇨🇦🇨🇦🇨🇦

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Reposted by Paola A. Marignani

BCCHR ResDev (DM) @resdevbcch.bsky.social · 12/02/2026

Wow. UBC has internal signature deadline that’s about 5 days before submission deadline, which is the day before CIHR deadline. People can work on Grant between signature deadline and submission deadline. (Schedule is advanced by ~1week if there’s a private sector partnership)

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Paola A. Marignani @pmarignani.bsky.social · 12/02/2026

What is your University internal deadline like? Single deadline or double deadline? -CIHR LOI date Feb 4, 2026 -Dalhousie FoM internal deadline on Uni server Feb 12, 2026 -Dalhousie ORS internal deadline on Uni server & ResearchNet Feb 17, 2026 CIHR Deadline Mar 4, 2016 @dalhousieu.bsky.social

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Paola A. Marignani @pmarignani.bsky.social · 11/02/2026

Today, on the #IWD2026, we celebrate the incredible contributions of women in STEM. It takes everyone working together to break down barriers and inspire the next generation of female scientists, innovators and tech entrepreneurs. @cdnwomenstem.bsky.social

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Paola A. Marignani @pmarignani.bsky.social · 10/02/2026

❄️☕👩🏻‍💻 Proanthocyanidins enhance antitumor immunity by promoting ubiquitin-proteasomal PD-L1 degradation via stabilization of #LKB1 and SYVN1 www.jci.org/articles/vie...

jci.org

JCI - Proanthocyanidins enhance antitumor immunity by promoting ubiquitin-proteasomal PD-L1 degradation via stabilization of LKB1 and SYVN1

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Paola A. Marignani @pmarignani.bsky.social · 08/02/2026

❄️☕👩🏻‍💻 Alessia Cara's overview of the Olympic fire in Canada. Happy Sunday🥇🥈🥉 #MilanoCortina2026 youtube.com/watch?v=pmVK...

youtube.com

The Gold Within: Family & Fire #cbcsports #milanocortina2026

YouTube video by CBC Sports

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