An experimental injection called CBL-514 reduced both fat beneath the skin and the deeper belly fat liposuction leaves behind in early human studies.

BUFFALO – The other guys, Sabres center Jiri Kulich noted, did the heavy lifting to create his first goal in 343 days, the late winner in Saturday’s thrilling 4-3 come-from-behind victory. Seconds bef...

Forward missed most of last season with blood clot; Thompson has two points for Buffalo

Key PointsPKMYT1 is highly expressed in del(17p) MM, and its inhibition represents a vulnerability.PKMYT1 inhibitor triggers DNA damage and mitotic catastr

A patient’s path to lifesaving treatment is shaped by more than medical innovation. At this year's TIME Health Leadership Forum (Sponsored by NMDP), NMDP Chief Executive Officer Amy Ronneberg joined ...

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We at CLL Ireland fully support this important campaign led by musician and farmer’s daughter Mags McCarthy to secure the go-ahead for a stem cell lab at Cork University Hospital (CUH). Mags spoke w...

Just published in NEJM! “Complete Regression of Hepatoblastoma after Interleukin-15– and Interleukin-21–Coexpressing CAR T-Cell Therapy” A 3-year-old child with metastatic, chemotherapy-resistant G...

Director of photography Bill Greene is retiring after a remarkable career at The Boston Globe. After 41 years, take a look at 41 of his photos.

AbstractDeveloping chimeric antigen receptor (CAR) T cells for acute myeloid leukemia (AML) has been challenging due to a lack of known AML-associated antigens that spare normal hematopoietic precurso...

The critical mineral has driven a wedge between Washington and Vilnius, as the Trump administration pressures a NATO ally to engage with Belarus—sidestepping the EU in the process.

Ringham et al. identify immunomodulatory cancer-associated fibroblasts that influence regulatory T cell dynamics in lung cancer.

Researchers at Columbia University have discovered a new type of cell that protects lung cancers from attacks by the immune system.

Key Points. The oncogene c-MYC is targetable at the mRNA level using a ribonuclease-targeting chimera (RiboTAC).MYC-RiboTAC exerts potent anti-myeloma acti

“We should not forget the lessons of history. And the lesson is those regulations have been very important.”...

Advanced glycation end products (AGEs) in proteins, a hallmark of aging, are considered irreversible. Here, authors report the development of CMLase - an enzyme that specifically oxidizes Nε-carboxyme...

Picca and Ferrucci synthesize current knowledge on mitochondrial quality control (MQC) mechanisms, their regulation during human ageing and their relevance to healthspan and longevity, highlighting em...

Stanley M. Gartler, Sorrell H. Waxman, Eloise Giblett, An XX/XY Human Hermaphrodite Resulting from Double Fertilization, Proceedings of the National Academy of Sciences of the United States of America...

Players take stage to announce Sabres Round 4 pick just months after losing teammate

From chemical building blocks, scientists have created synthetic cells that have most of the hallmarks of life.

Players take stage to announce Sabres Round 4 pick just months after losing teammate

Antibody affinity maturation results from a somatic evolutionary process that takes place in the germinal center. A “parallel replay” experiment on germinal center B cells reveals the evolutionary for...

Persons carrying loss-of-function variants of proprotein convertase subtilisin–kexin type 9 (PCSK9) have reduced levels of low-density lipoprotein (LDL) cholesterol and fewer atherosclerotic cardio...

T hey bind sugar. They talk to tumours. And they may be the next frontier in cancer immunotherapy. Every cell in your body is coated in a de...

T hey bind sugar. They talk to tumours. And they may be the next frontier in cancer immunotherapy. Every cell in your body is coated in a de...

A genome-wide association study combining data from the Estonian Biobank and the UK Biobank identifies many common and low-frequency locus–metabolic trait associations, enabling the identification of ...

Joining the International Myeloma Society Annual Meeting to connect and collaborate in myeloma research.

In a first-in-human trial combining the transplantation of CD33-negative CRISPR-edited hematopoietic cells with the CD33-targeted antibody–drug conjugate gemtuzumab ozogamicin, all transplanted patien...

Signal Transduction and Targeted Therapy - The mechanosensitive adhesion G protein-coupled receptor 133 (GPR133/ADGRD1) enhances bone formation