Reposted by Brandon PickettAdam Phillippy @aphillippy.bsky.social · 27/01/2025Congrats to Bryce Kille on absolutely smashing his PhD defense at Rice today with advisor @treangen.bsky.social ! Collaborating with Bryce over the past few years has been an absolute delight 👏🎉👏🎉 2336
Reposted by Brandon PickettAdam Phillippy @aphillippy.bsky.social · 02/01/2025We may have cut our last Canu release in 2024, but we are starting off 2025 with Verkko2! 🎉 Not only is it 4x faster than Verkko1, this version integrates Hi-C data for both phasing and scaffolding, enabling the automated assembly of acrocentric chromosomes! Preprint: www.biorxiv.org/content/10.1... 58631
Reposted by Brandon PickettAdam Phillippy @aphillippy.bsky.social · 27/09/2024"The formation and propagation of human Robertsonian chromosomes" ROBs are the most common translocation in humans, approx. ~1 per 800 people. Last year we proposed a simple mechanism for ROB formation; This year we prove it by finishing some T2T! New preprint: www.biorxiv.org/content/10.1... 13114
Reposted by Brandon PickettShawn Burgess @burgesslab.bsky.social · 11/09/2024Very happy to see the NIH director co-author this opinion piece. elifesciences.org/articles/102...elifesciences.orgPoint of View: Applied research won’t flourish without basic scienceThree senior figures at the US National Institutes of Health explain why the agency remains committed to supporting basic science and research. 021
Brandon Pickett @pickettbd.bsky.social · 26/01/2024Genome assembly is difficult, but we reduce some of the mystery and barriers to entry (both w.r.t. knowledge and compute resources) by implementing our pipeline in Galaxy: www.nature.com/articles/s41... Thanks to many, incl. @mikeschatz.bsky.social @aphillippy.bsky.social @arhie.bsky.socialnature.comScalable, accessible and reproducible reference genome assembly and evaluation in Galaxy - Nature Bi...Nature Biotechnology - Scalable, accessible and reproducible reference genome assembly and evaluation in Galaxy 0159
Reposted by Brandon PickettAdam Phillippy @aphillippy.bsky.social · 02/12/2023So we decided not to stop with human and have finished sex chromosomes for the great apes as well 🙊 They make for the prettiest dotplots, e.g. compare human Y vs. bonobo Y. So many palindromes! 📄 "The Complete Sequence and Comparative Analysis of Ape Sex Chromosomes" www.biorxiv.org/content/10.1... 12611
Reposted by Brandon PickettAdam Phillippy @aphillippy.bsky.social · 05/10/2023"The p-Arms of Human Acrocentric Chromosomes Play by a Different Set of Rules" An excellent review by Brian McStay on these newly completed regions of the human genome and why you should care: www.annualreviews.org/doi/abs/10.1...annualreviews.org 034
Brandon Pickett @pickettbd.bsky.social · 27/09/2023@danirabaiotti.bsky.social do I need to do anything special to become a contributor to the What’s Science feed? Still learning about how these work.. 150
