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Physiological Reports @physrep.bsky.social · 29/09/2026

This study provides prospective, #myocardial strain-based #echocardiography characterization of #cardiac development in #C57BL/6 mice between P0 and week 8, with the P21-Wk8 interval important for sex-specific #cardiac #mechanics. doi.org/10.14814/phy...

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Physiological Reports @physrep.bsky.social · 25/09/2026

Comparative analysis of #serum #metabolomes from untrained young adults after traditional combined #exercise or high-intensity tactical training reports distinct and time-dependent signatures of #metabolic changes. doi.org/10.14814/phy...

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Physiological Reports @physrep.bsky.social · 14/09/2026

This year’s #PeerReview week, 14th to 18th Sept 2026, has the theme Peer Review Capacity: Volume, Speed, and Quality Find out more at peerreviewweek.net @physoc.bsky.social @apspublications.bsky.social @wileylifesci.bsky.social

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Physiological Reports @physrep.bsky.social · 09/09/2026

This new #Methods article presents a rapid method to isolate and culture primary #pulmonary #artery #smoothmuscle #cells from rat lungs, as a cell culture model to study mechanisms of hypoxic pulmonary #vasoconstriction. doi.org/10.14814/phy...

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Physiological Reports @physrep.bsky.social · 25/08/2026

Did you know that you can use a QR code to link a @PhysReports article? To activate this feature: at the journal home page, find tab ‘manage cookies’ in the Wiley page footer, then enable ‘targeted cookies’. The QR option will then show on the list of sharing options for your selected paper!

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Physiological Reports @physrep.bsky.social · 24/08/2026

This Review on pathophysiological mechanisms of #ventricular #arrhythmogenesis in #pulmonary #hypertension discusses translational implications and highlights gaps in #research knowledge. doi.org/10.14814/phy... #Cardiovascular

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Physiological Reports @physrep.bsky.social · 21/08/2026

#Hemodynamic studies of #heart function in a rat model of controlled cortical impact indicates that #traumatic #brain #injury is associated with #cardiovascular dysfunctions that varies with injury severity. doi.org/10.14814/phy...

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Physiological Reports @physrep.bsky.social · 18/08/2026

Find out more and submit your manuscript! physoc.onlinelibrary.wiley.com/journal/2051... Physiology @physoc.bsky.social @apspublications.bsky.social @wileylifesci.bsky.social

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Physiological Reports @physrep.bsky.social · 17/08/2026

Physiological mechanisms underlying sex- and age-dependent differences in #cardiovascular #disease susceptibility are poorly understood. This Review discusses #sex-specific #vascular responses to acute stressors across the #lifespan. doi.org/10.14814/phy... #Ageing @wileylifesci.bsky.social

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Physiological Reports @physrep.bsky.social · 12/08/2026

This study reports on the association of near #infrared #spectroscopy-derived #muscle oxidative capacity with maximal and sustainable oxidative metabolic predictors of performance in highly trained female runners. doi.org/10.14814/phy... #Metabolism #Athletes #FemalePhysiology

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Physiological Reports @physrep.bsky.social · 10/08/2026

Read this new #Review that discusses the #physiology and pathophysiological mechanisms of #chronic #cough and current targets for prospective #pharmacotherapy. doi.org/10.14814/phy... #Respiratory @physoc.bsky.social @apspublications.bsky.social

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Physiological Reports @physrep.bsky.social · 27/07/2026

#Muscle from aged female mice exhibits dysregulated #inflammation and #kinase-signaling and altered functional dynamics after volumetric muscle loss, despite a structural pathology similar to that of young mice. doi.org/10.14814/phy... #Ageing #Healthspan #FemalePhysiology

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Physiological Reports @physrep.bsky.social · 22/07/2026

Investigation of the roles of C3 or C5 #complement components in driving #ischemia–#reperfusion injury in C3−/− and C5−/− knockout mice demonstrates distinct roles of C3 in #renal injury and repair mechanisms. doi.org/10.14814/phy...

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Physiological Reports @physrep.bsky.social · 13/07/2026

#Tuftcells, activators of type 2 innate lymphoid cells, are absent from the distal lung in health but differentiate there after #lung #injury in #influenza. This study gives evidence in mouse models for a post-infection distal-airway tuft-cell–ILC2 pathway. doi.org/10.14814/phy... #Innate #Immunity

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Physiological Reports @physrep.bsky.social · 08/07/2026

Monitoring of ultra-short resting #heartrate and cardiometabolic health over 7 days under free living conditions indicates association of resting heart rate parameters with cardiometabolic health doi.org/10.14814/phy... Object Identifier (DOI) #Wearable #technology #Exercise #HRV

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Physiological Reports @physrep.bsky.social · 06/07/2026

This study reports on metabolic similarities and differences between #Huh7cells and primary human #hepatocytes cultured in physiologically-relevant media. doi.org/10.14814/phy... #Metabolism #Transcriptomics #CellCulture #Lipids

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Physiological Reports @physrep.bsky.social · 29/06/2026

Investigation of pulsed #ultrasound for #ischemia therapy reports improved blood flow in a mouse ischaemia model, with evidence for signaling by an #integrin- #Erk1/2 pathway in an #endothelialcell #angiogenesis model in vitro. doi.org/10.14814/phy...

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Physiological Reports @physrep.bsky.social · 22/06/2026

This study reports on differences in #inflammation, #hepcidin and #endotoxin responses to #exercise under hot versus cool environmental conditions in endurance-trained female #athletes. doi.org/10.14814/phy... #Thermal #Physiology #HeatStress

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Physiological Reports @physrep.bsky.social · 10/06/2026

This study examines #saliva #miRNAs, circulating #redox markers and urinary exercise-induced markers before, and acute responses after completion of, an extreme #mountain #ultramarathon in adult male runners. doi.org/10.14814/phy...

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Physiological Reports @physrep.bsky.social · 10/04/2026

This new Review discusses the therapeutic potential of #coldexposure in #obesity, #diabetes, #inflammation and #cancer in #pre-clinical models and humans and current limitations for clinical translation. doi.org/10.14814/phy...

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Physiological Reports @physrep.bsky.social · 07/04/2026

Sex differences in the #interleukin-6 and derivative-reactive oxygen #metabolites responses to moderate-intensity #exercise in healthy adults are shown to be due to workload. doi.org/10.14814/phy... #Physiology

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Physiological Reports @physrep.bsky.social · 02/04/2026

Analysis of the interplay between #uromodulin excretion and #water balance in a healthy adult population reports associations with #urine volume, urine #osmolality and #copeptin levels. doi.org/10.14814/phy... #Renal

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Physiological Reports @physrep.bsky.social · 23/03/2026

Congratulations to the 2026 @PhysRep Presentation Award Winners at Physiological Society of Japan 103rd Annual Meeting! www.aeplan.jp/psj2026/home... Ken Ueda, The University of Tokyo Kanoko Ashizawa, Nagasaki University @physoc.bsky.social @apspublications.bsky.social @wileylifesci.bsky.social

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Physiological Reports @physrep.bsky.social · 19/03/2026

New data on role of CaM kinase II in #myocardium stretch-induced compliance, independent of protein #kinase G, but likely through shared #phosphorylation targets with PKG, implicating #CaMKII as a possible modulator of diastolic function doi.org/10.14814/phy... #Cardiac #Physiology

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Physiological Reports @physrep.bsky.social · 16/03/2026

Comparison of #vascular, #hemodynamic, and #autonomic responses induced by #cold or mental #stress in young adults reports different time-courses of response to these stressors. doi.org/10.14814/phy... #StroopTest #Thermal #Physiology

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Physiological Reports @physrep.bsky.social · 12/03/2026

Our latest #Methods article show how oral essential #aminoacid tracer ingestion can be used as an alternative method to detect changes in #myofibrillar #protein #synthesis in response to mixed macronutrient #feeding or feeding plus #exercise. doi.org/10.14814/phy... #SkeletalMuscle

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Physiological Reports @physrep.bsky.social · 10/03/2026

Assessment of seasonal variation in #cutaneous #microvasculature function in healthy adults shows lower #nitricoxide mediated cutaneous #vasodilation in winter/early-spring compared to summer/early-fall. doi.org/10.14814/phy... #Endothelium

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Physiological Reports @physrep.bsky.social · 06/03/2026

Light-to-moderate physical activity under cold air conditions is shown to alter ventilatory patterns by increases to tidal volume, providing new insight into the unique physiological challenges of work in cold environments. doi.org/10.14814/phy... #Exercise #Respiratory #Physiology

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Physiological Reports @physrep.bsky.social · 10/02/2026

Find out about the most-read papers published in Physiological Reports in 2025. With congratulations to the authors! @physoc.bsky.social @apspublications.bsky.social @wileylifesci.bsky.social

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Physiological Reports @physrep.bsky.social · 02/02/2026

#Renal focal global #glomerulosclerosis relates to #aging and #hypertension and begins with tuft contraction of #glomeruli. This report shows associated #biomarkers of #podocyte depletion, cell #senescence, and activation of #parietal #epithelia #cells. doi.org/10.14814/phy... #Kidney #Physiology

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Physiological Reports @physrep.bsky.social · 23/01/2026

The editors are pleased to announce the appointment of Jacqueline K. Limberg, Ph.D., University of Missouri, USA, as a new Associate Editor at PhysReports! Dr. Limberg brings expertise in #autonomic #physiology, #cardiovascular regulation and sex differences, in health and #obesity.

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Physiological Reports @physrep.bsky.social · 19/01/2026

Analysis of whether #BMI influences an adult's ability to adapt during #heat #acclimation, tested by treadmill walking over 8d at 40C, reports individuals with BMI >25 may have attenuated core #temperature adaptations. doi.org/10.14814/phy... #Exercise #ThermalPhysiology

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Physiological Reports @physrep.bsky.social · 16/01/2026

Comparison of #exercise sweating and #pilocarpine induced #sweat testing (a lab-based method to assess sweat composition) reports best match at moderate exercise intensity in trained #athletes. doi.org/10.14814/phy... Object Identifier (DOI) @physoc.bsky.social @apspublications.bsky.social

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Physiological Reports @physrep.bsky.social · 23/12/2025

The Editors Thank all Authors, Reviewers, Readers, Editorial Board members and Staff for their support of the success of Physiological Reports in 2025! Best wishes for a Happy festive season and a productive 2026. @physoc.bsky.social @apspublications.bsky.social @wileylifesci.bsky.social

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Physiological Reports @physrep.bsky.social · 11/12/2025

129S2/SvPas mice are susceptible to #hypertension from dietary #electrolyte manipulation. In a #doxorubicin-induced #proteinuria model, 129S2/SvPas mice proved resistant to proteinuria compared to 129S1/SvImJ mice, and proteolytic processing of #renal #ENaC was not increased doi.org/10.14814/phy...

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Physiological Reports @physrep.bsky.social · 26/11/2025

Postprandial #exercise is recommended for people with metabolic disease. This study reports reduced postprandial #insulin and #glucose among young and old active exercisers, with association to #cognitive function and #bodywater compartment ratio. doi.org/10.14814/phy... #Metabolism #Ageing

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Physiological Reports @physrep.bsky.social · 25/11/2025

Investigation of #masseter #muscle in #microphthalmia mice (with Mitf mutation and masticatory dysfunction) shows increased myocyte #apoptosis and #fibrosis, reduced masseter muscle mass and low expression of #microRNAs needed for #skeletal muscle development doi.org/10.14814/phy...

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Physiological Reports @physrep.bsky.social · 17/11/2025

#CarbonMonoxide has #antiischemic and #antiinflammatory effects. This study explores the potential of #CORMA1, a molecule that effects controlled CO release, to protect #kidneys from warm #ischemia and #reperfusion injury in rat and swine models. doi.org/10.14814/phy...

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Physiological Reports @physrep.bsky.social · 13/11/2025

New data on #mitochondria Aminoacyl-#tRNASynthetase, DARS2, reports secretion by #airway #epithelial cells in response to #TNFα, and a role in #paracrine signaling resulting in M1 #macrophage like phenotype in recipient THP1 cells. doi.org/10.14814/phy...

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Physiological Reports @physrep.bsky.social · 12/11/2025

Deadline approaching! Call for Papers on “Tissue Fibrosis Through the Life Course and in Transplanted Organs” will close on 31st Dec. 2025! Including, but not limited to: Age-related Fibrosis Organ Fibrosis Fibrosis in Transplanted Organs More Info: physoc.onlinelibrary.wiley.com/hub/journal/...

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Physiological Reports @physrep.bsky.social · 10/11/2025

This systematic review examines evidence for #Sexdifferences in human #skeletal #muscle fiber types and the influences of #age, physical activity or muscle group. doi.org/10.14814/phy... MyoBlue #Exercise #Ageing #Physiology

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Physiological Reports @physrep.bsky.social · 04/11/2025

Study of #heartrate variability in two birth cohorts, in Finland or Norway, indicates altered #autonomic regulation in adults born preterm with very low birth weight, especially women, potentially contributing to higher #bloodpressure. doi.org/10.14814/phy... #Birth #Cardiovascular

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Physiological Reports @physrep.bsky.social · 03/11/2025

#TRPC6 channels are implicated in pathogenesis of severe #nephrotic syndromes. This study of TRPC6 in normal physiological #podocyte functions reports roles in #MMP7-shedding of #nephrin ectodomains and #apoptosis. doi.org/10.14814/phy... #Renal #IonChannels

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Physiological Reports @physrep.bsky.social · 31/10/2025

Retrospective cohort study on effects of #caffeine in persons starting #Sodium-glucose #cotransporter-2 inhibitors, indicates high caffeine consumption may reduce the early decline in estimated #glomerular #filtration rate with SGLT2i therapy. doi.org/10.14814/phy... #Heart #Kidney

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Physiological Reports @physrep.bsky.social · 30/10/2025

This new invited Review discusses how food-related #gut or #endocrine signals and #microbial #metabolites are detected by vagal pathways in #Interoception mediated regulation of #feeding and #glucose #metabolism. doi.org/10.14814/phy...

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Physiological Reports @physrep.bsky.social · 22/10/2025

New #Methods article surveys #photophysical and spectral properties of popular #pH-sensing green fluorescent proteins, #pHluorins, including a new member pHluorin4, providing insights to optimize applications in different systems. doi.org/10.14814/phy... #GFP #FluorescentProteins #CellPhysiology

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Physiological Reports @physrep.bsky.social · 21/10/2025

This study uses continuous video-recorded transnasal #laryngoscopy and simultaneous #airway pressure measurement to quantify the airflow resistance at these sites during noninvasive #ventilation in healthy adults. doi.org/10.14814/phy... #Respiratory

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Physiological Reports @physrep.bsky.social · 06/10/2025

Comparison of #respiratory regulation and #lung volume in healthy young adults undertaking land-based or aquatic #cycling matched for oxygen uptake (VO2) indicates #exercise in an aquatic environment can be more effective for training the respiratory system doi.org/10.14814/phy...

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Physiological Reports @physrep.bsky.social · 03/10/2025

Study of individuals with a permanent #pacemaker and preserved LV #systolic function reports right #ventricle pacing frequency and implantation >60 months to be independently associated with increased cellular and #mitochondria #oxidativestress in PBM cells doi.org/10.14814/phy...

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