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Philip Bejon

@philipbejon.bsky.social

177 followers 170 following 186 posts

Director @modmedmicro.bsky.social; Previous Director @kemri_wellcome; Researcher on vaccines, malaria, viruses; Clinical Microbiologist, Infectious Disease, General Medicine

Posts Replies Media

Philip Bejon @philipbejon.bsky.social · 18/08/2026

So why? Final snip shows, despite climate change, not to do with overall rainfall (panel A), but masses of bednets distributed since 2008 (panel B), more and more use to date, and also drug treatment has improved (panel C).

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Philip Bejon @philipbejon.bsky.social · 18/08/2026

Second snip shows mortality due to malaria. Similar pattern, goes from 0.5 per 1000 children dying per year (massive mortality from one single pathogen) down to no deaths 2021-24. From a major killer to nothing.

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Philip Bejon @philipbejon.bsky.social · 18/08/2026

First snip shows background malaria prevalence in community (panel A) and admissions per 1000 children (panel B). Huge drop from peaks in 1990/1999, to lows in 2008, slight rise to 2014 (we worried about resurgence due to less immunity) but then, unexpectedly falls to nothing in 2021-24.

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Philip Bejon @philipbejon.bsky.social · 14/01/2026

3/4 Trial include 420 infants, seroconversion (i.e. response) rate was 99% for standard dose, but only 93% for fractional dose. This did not meet "non-inferiority" criteria - i.e. we cannot accept that fractional doses are as good as standard in infants.

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Philip Bejon @philipbejon.bsky.social · 14/01/2026

2/4 Previously, we showed that 500 unit ("fractional") doses were as good as 13,000 unit ("standard") doses in adults - pmc.ncbi.nlm.nih.gov/articles/PMC... - so can be used for outbreak responses. But most routine vaccines are in infants, we couldn't assume same responses, so we did a trial.

Appearance of yellow fever virus by EM with colouring effect on image.

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Philip Bejon @philipbejon.bsky.social · 14/01/2026

1/4 Our latest trial of yellow fever vaccination dosing in infants - doi.org/10.1016/S014.... Why did we do the trial? The problem is that although yellow fever vaccine works very well, stocks are limited and can't always control outbreaks.

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Philip Bejon @philipbejon.bsky.social · 06/01/2026

1/6 Our paper today – www.nature.com/articles/s41... work from Kenya - shows protective antibodies against falciparum malaria sporozoites work against sporozoites injected into the skin, not against sporozoites injected into veins. Why does this matter?

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Philip Bejon @philipbejon.bsky.social · 29/05/2025

Fantastic game. I especially enjoyed seeing software development demonstrating fixing bugs on the spot to deal with new hardware. Then a period with an MVP and development version in parallel. Then a hack fix, but developers locked in to finding an elegant solution while the game continued.

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