iiinova — where your digital self keeps evolving

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Europe PMC @europepmc.org · 09/07/2025

Open licenses power discovery! Melissa Harrison shares a @pfamdb.bsky.social use case: Pfam uses AI to extract information about known protein domains This helps predict protein function & identify potential drug targets! 💊 #ChooseOpenWebinar for live updates 💡 #MedLib #PhDsky #OpenAccess

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Reposted by PfamDB

InterPro @interprodb.bsky.social · 18/07/2025

🧬 The InterPro/Pfam team will be presenting at #ISMB2025 next week in Liverpool! 🎤 Multiple talks & 📊 posters on protein analysis & classification 💻🧪

Poster A-098: Pfam database in 2025 – towards expanding protein families coverage
Nicole Morveli Flores
Session A: 21/07/2025
10:00 – 11:20 and
16:00 – 16:40 BST
Image credit: BioImage Archive accession S-BSST584.
Design credit: Karen Arnott/EMBL-EBI

InterProScan 6: a modern large-scale protein function annotation pipeline
Matthias Blum
21/07/2025 14:20
Room 03A
Image credit: BioImage Archive accession S-BSST584. Design credit: Karen Arnott/EMBL-EBI

Poster A-205: Carbohydrate active enzymes in Pectobacteriaceae: coevolving enzyme sets and host adaptation
Emma Hobbs
Session A: 21/07/2025
10:00 – 11:20 and
16:00 – 16:40 BST
Image credit: BioImage Archive accession S-BSST584.
Design credit: Karen Arnott/EMBL-EBI

Accelerating protein family classification in InterPro with AI innovations
Matthias Blum
22/07/2025 16:40
Room 12
Image credit: BioImage Archive accession S-BSST584.
Design credit: Karen Arnott/EMBL-EBI

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Reposted by PfamDB

InterPro @interprodb.bsky.social · 18/07/2025

🧬 The InterPro/Pfam team will be presenting at #ISMB2025 next week in Liverpool! Join us July 20-24 at the world's largest #bioinformatics conference! #ISMBECCB2025 #ProteinAnalysis #ComputationalBiology 💻🧪

The InterPro/Pfam team members attending ISMB/ECCB 2025: Alex Bateman, Emma Hobbs, Matthias Blum, Nicole Morvelli, Antonina Andreeva
Image credit: BioImage Archive accession S-BSST584.
Design credit: Karen Arnott/EMBL-EBI

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Reposted by PfamDB

Europe PMC @europepmc.org · 23/06/2025

Can AI train on my openly licensed research? Do I retain copyright if I choose a CC BY license? Why can’t I reuse a figure from my own paper? Get the answers in a webinar with Creative Commons, #EuropePMC & EMBL 🗓️ 9 Jul ⏰ 15:00 UTC 🔗 embl-org.zoom.us/webinar/regi... #OpenScience #AcademicSky 🧪

Promotional slide for a webinar titled "What happens when you choose closed? What Creative Commons licenses mean for research and AI." The slide features photos and names of five speakers: Melissa Harrison (Europe PMC / EMBL-EBI), Katherine Hughes (EMBL), Taylor Campbell (Creative Commons), Monica Granados (Creative Commons), and Kat Walsh (Creative Commons). Logos for Europe PMC, Creative Commons, and EMBL are shown at the bottom. The background is green with white text.

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PfamDB @pfamdb.bsky.social · 20/06/2025

🚀 HUGE NEWS: Pfam 37.4 is LIVE! 318 brand-new protein families + 4 new clans! 🧬 Total collection now: 24,736 entries! 📈 Get exploring via InterPro website, API & Pfam FTP! 💻🧪

Content
Over 24,736 entries describing protein families, domains and repeats.

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Reposted by PfamDB

InterPro @interprodb.bsky.social · 20/06/2025

🚀 InterPro 106.0 is now live! ✨ Updated to Pfam 37.4 ✨ 683 new entries added ✨ Enhanced protein classification coverage Explore the latest annotations and discover new protein insights. Explore it now: interpro.ebi.ac.uk 💻🧪🧬 #Bioinformatics #ProteinScience #Pfam #EMBLEBI

New entries:
683 new entries with:
613 Pfam
78 NCBIfam
30 CDD
4 PANTHER
...

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Reposted by PfamDB

Protein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · 16/06/2025

What’s new in the redesigned PDBe entry pages? 🧪 Cleaner layout 🧪 Interactive 3D viewers 🧪 Contextual annotations 🧪 Easier navigation See for yourself: wwwdev.ebi.ac.uk/pdbe/entry/p... #PDBeBeta #Bioinformatics #Biochemistry #Science

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InterPro @interprodb.bsky.social · 15/05/2025

🧬 MAJOR UPDATE: InterPro-N matches now available in InterPro! 1.8 billion AI-driven protein annotations developed with Google DeepMind are now live. ✨ Look for the sparkles icon to identify them 📊 Options menu lets you view: InterPro only | InterPro-N-only | Stacked 💻🧪

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Reposted by PfamDB

InterPro @interprodb.bsky.social · 08/05/2025

🔍 NEW: TED domains in InterPro 105.0! For the first time, see AlphaFold-derived structural domains directly alongside InterPro annotations in one powerful visualisation. Bridging the sequence-structure divide in protein analysis. 💻🧪 Explore now: www.ebi.ac.uk/interpro/pro...

TED domains alongside InterPro annotations for UniProt P05067

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Reposted by PfamDB

InterPro @interprodb.bsky.social · 01/05/2025

📝 Check out our new blog post highlighting the groundbreaking features in InterPro 105.0! Learn how InterPro-N, TED domains and viral protein structures are transforming protein classification: ebi.ac.uk/about/news/u...

InterPro 105.0: AI for protein classification
InterPro 105.0 is now live. This AI-driven update makes it easier than ever to explore the protein universe

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PfamDB @pfamdb.bsky.social · 25/04/2025

🔥 Pfam 37.3 just dropped! 🚀 353 incredible new protein families + 7 new clans! 🧬✨ Revolutionise your research NOW via @interprodb.bsky.social website, API & Pfam FTP!

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Reposted by PfamDB

InterPro @interprodb.bsky.social · 24/04/2025

📢InterPro release 105.0 is live! ✨Update to Pfam 37.3, PROSITE patterns 2025_01 PROSITE profiles 2025_01 and HAMAP 2025_01 ✨342 new entries ✨Addition of InterPro-N annotations ✨Addition of BFVD structure predictions from @martinsteinegger.bsky.social's lab Have a look: ebi.ac.uk/interpro/htt... 💻🧪🆕

Databases updates
Pfam 37.3
PROSITE patterns 2025_01
PROSITE profiles 2025_01
HAMAP 2025_01

New entries
342 new entries with:
318 Pfam
40 NCBIfam
12 Prosite profiles
6 PANTHER
5 CDD

New features
InterPro-N annotations
BFVD structure predictions
Simplified structure pages

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Reposted by PfamDB

InterPro @interprodb.bsky.social · 02/04/2025

Want to use the InterPro API but not sure how to start? Join this upcoming workshop, where @typhainepl.bsky.social will guide you through the fundamentals and practical applications. Discover how to integrate this powerful tool into your workflow! Register now to secure your spot. 💻🧪

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Reposted by PfamDB

InterPro @interprodb.bsky.social · 06/02/2025

🔈InterPro release 104.0 is live! ✨Update to Pfam 37.2, NCBIfam 17.0, CDD 3.21. ✨661 new entries, including 682 signatures from the Pfam (663), NCBIfam (5), PANTHER (5), CDD (9) databases. Have a look: ebi.ac.uk/interpro/ 💻🧪

Databases udpates:
Pfam 37.2, NCBIfam 17.0, CDD 3.21

661 new entries, containing:
663 Pfam
5 NCBIfam
5 PANTHER
9 CDD

New features:
Redesigned protein viewer for sequence searches
Wikipedia articles for Pfam clans
Addition of PTM from the PRIDE database

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PfamDB @pfamdb.bsky.social · 06/02/2025

Pfam 37.2 is out 🎉It contains 302 new families and 18 new clans You can have a look at them in InterPro: ebi.ac.uk/interpro/ent... or download the release from the Pfam ftp: ftp.ebi.ac.uk/pub/database...

Pfam 37.2: 302 new families and 18 new clans

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PfamDB @pfamdb.bsky.social · 24/01/2025

🔍 Lost in Pfam data? Our redesigned Help page has you covered! From quick answers to deep dives into protein families, find exactly what you need at www.ebi.ac.uk/interpro/help/ 💻🧪

InterPro website (home of Pfam) Help page

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Reposted by PfamDB

EMBL-EBI @ebi.embl.org · 16/12/2024

Prediction confidence scores help #AlphaFold users gauge the reliability of protein structure predictions. 🖥️🧬 But things get more challenging for protein families. A new method helps improve low confidence predictions within protein families. academic.oup.com/bioinformati...

Protein structure prediction from the AlphaFold Database

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Reposted by PfamDB

InterPro @interprodb.bsky.social · 16/01/2025

🆕The member database signature pages have undergone a thoughtful reorganisation to improve information accessibility. 1) Curation data are now in Overview 2) HMM information and logo are now in Profile HMM Have a look: www.ebi.ac.uk/interpro/ent...

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Reposted by PfamDB

EMBL-EBI Training @training.ebi.embl.org · 06/01/2025

Welcome to 2025 🎉 We are running a number of exciting courses this year, so join us to boost your #bioinformatics, #datascience and #omics skills! These courses are currently open for applications - find out more: www.ebi.ac.uk/training/liv... 💻🧬💻🧪

Cancer genomics and transcriptomics. Virtual. Closes 9 February.

Introduction to metabolomics analysis. Hinxton. Closes 2 Feburary.

Data science for life scientists. Hinxton. Closes 2 March.

Data visualisation for biology. Hinxton. Closes 9 March.

Systems biology: from large datasets to biological insight. Hinxton. Closes 16 March.

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Reposted by PfamDB

Francesco Costa @atsocf.bsky.social · 09/12/2024

Excited to announce our latest publication: “Keeping it in the family: Using protein family templates to rescue low confidence AlphaFold2 models” where we explore plDDT variability in #AF2 models of @pfamdb.bsky.social domains. doi.org/10.1093/bioa... 1/7

doi.org

Keeping it in the family: using protein family templates to rescue low confidence AlphaFold2 models

AbstractMotivation. High confidence structure prediction models have become available for nearly all protein sequences. More than 200 million AlphaFold2 mo

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PfamDB @pfamdb.bsky.social · 09/12/2024

🧬 What's new in Pfam? Beta propellers uncovered through smart deduplication, fresh perspectives on haloarchaeal proteins, and more! Dive into our latest blog: xfam.wordpress.com/2024/12/09/p...

xfam.wordpress.com

Pfam 37.1 release

Pfam 37.1 release is now out and accessible through the InterPro website and Pfam ftp. More frequent Pfam updates Historically, Pfam releases occurred approximately once per year. With the de…

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PfamDB @pfamdb.bsky.social · 29/11/2024

For the latest Pfam updates, have a look at our recently published paper: The Pfam protein families database: embracing AI/ML t.co/8auCxw3mdj

NAR graphical abstract:
Pfam coverage
Using AlphaFold to build new Pfam domains
Use of deep learning to Increase coverage of UniProtKB
Improved coverage of repeated domains

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Reposted by PfamDB

InterPro @interprodb.bsky.social · 29/11/2024

InterPro release 103.0 is live! 💻🧪 ✨Update to Pfam 37.1 ✨1029 new entries, including 1019 signatures from the Pfam (1008), NCBIfam (2), PIRSF (1), PANTHER (1), CDD (7) databases. Have a look: ebi.ac.uk/interpro/

InterPro release 103.0: 28th November 2024

1029 new entries containing:
1008 Pfam
2 NCBIfam
1 PIRSF
1 PANTHER
7 CDD

New features:
Redesigned protein viewer
Improved dataset browsing
Streamlined website navigation
Member database entry page updates

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PfamDB @pfamdb.bsky.social · 20/11/2024

We’re delighted to have joined BlueSky to engage with the scientific community about protein families, protein domains and related data. The Pfam database is a large collection of protein families, domains and repeats.

Pfam: collection of protein families and domains
Content: Over 21,000 entries describing protein families, domains and repeats.
Training available on the EMBL-EBI training platform

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