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Reposted by Lynn Petukhova

NYU Pain Research Center @nyupainresearch.bsky.social · 30/05/2025

New research from the Zamponi Lab! They've identified a novel USP5 mutation linked to pain insensitivity. Their study, using a CRISPR knock-in mouse model, reveals R24W USP5 as a dominant-negative regulator of Cav3.2 channels, leading to reduced pain. rupress.org/jem/article/...

rupress.org

A pathological missense mutation in the deubiquitinase USP5 leads to insensitivity to pain | Journal of Experimental Medicine | Rockefeller University Press

The manuscript reports on patient with a USP5 mutation that gives rise to insensitivity to pain. The patient’s pathology is phenocopied in a knock-in mouse

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