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Piotr Draczkowski @pdracakowski.bsky.social · 15/10/2025

A special thanks to @asibc512.bsky.social, Szu-Ni Chen, Ting Chen, Yong-Sheng Wang, Yuan-Chih Chang, and all the coauthors for making this possible

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Piotr Draczkowski @pdracakowski.bsky.social · 15/10/2025

It has been a long but incredibly valuable journey, filled with ups and downs, culminating in an exhausting publishing process. Despite all the challenges, thanks to the tremendous efforts of all the coauthors, our publication is finally out!

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Piotr Draczkowski @pdracakowski.bsky.social · 15/10/2025

In this study, we expand the structural understanding of the ubiquitin code by revealing previously unseen K11/K48-branched Ub chain topology and its recognition by the proteasome.

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Reposted by Piotr Draczkowski

asibc512.bsky.social @asibc512.bsky.social · 15/10/2025

What a day! We published two papers describing the lives of proteins from Alpha shorturl.at/ZeAG7 to Omega shorturl.at/b79Eu Seeing these processes through the lens of structural biology is so satisfying

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Reposted by Piotr Draczkowski

asibc512.bsky.social @asibc512.bsky.social · 15/10/2025

We discovered how an engineered ribosome arrest peptide (eRAP) acts as a built-in “pause button” to precisely control protein synthesis. eRAP merges two natural stalling systems to stop the ribosome at just the right time — shaping how nascent proteins begin to fold. academic.oup.com/nar/article/...

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Reposted by Piotr Draczkowski

asibc512.bsky.social @asibc512.bsky.social · 15/10/2025

Excited to share our Nature Communications paper 🎉 rdcu.be/eK7wG We uncovered by cryoEM how the human proteasome recognizes branched K11/K48 ubiquitin chains through a new K11-binding site in the RPN2 subunit, revealing how the proteasome precisely identifies targets for rapid turnover. #cryoEM

rdcu.be

Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome

Nature Communications - K11/K48 branched ubiquitin chains regulate protein degradation and cell cycle progression. Here, the authors report the structural basis of how such a branched ubiquitin...

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Piotr Draczkowski @pdracakowski.bsky.social · 14/01/2025

Here’s a brief teaser for our latest preprint reporting the first structures of the K11/K48-branched Ub chain bound to the human proteasome: youtu.be/lAZrYsnoLBc?... Check the full text for more details: biorxiv.org/content/10.1... Thx to @asibc512 for making this possible!

youtu.be

Structural basis of a K11/K48-branched ubiquitin chain bound to the 26S human proteasome

YouTube video by Academia Sinica IBC512

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