How does a single carbon atom rewire a cancer-associated protein? Our study published in Nat Comm doi.org/10.1038/s414... combined methyl NMR spectroscopy with 40+ cancer-associated mutants to decode the allosteric communication network of the tumor suppressor BAP1.
doi.org
Allosteric network of dynamic coupling within BAP1-UCH revealed by methyl NMR - Nature Communications
BAP1 is a tumor-suppressor deubiquitinase that helps control how genes are switched on and off. In this study, the authors use NMR spectroscopy to examine how more than 40 cancer associated and relate...
