Models (i.e., governing equations) are fundamental to science and engineering. Advances in data acquisition now make it possible to extract interpretable, low-dimensional descriptions from high-dimens...

Analysis of nearly 200 human gut microbiome datasets shows that microbial coexistence is governed by a few effective ecological dimensions, rather than the high-dimensional niches assumed by prevailing theory.

Information theoretic framework for quantifying trancriptional regulation - emisbrooke/InFlow

Emison et al. develop an information-theoretic framework that decomposes communication fidelity in gene regulatory networks. Applying this framework to single-cell RNA-seq data across aging tissues, they find that communication fidelity declines, driven primarily by shifting input distributions rather than increased channel noise.

Deguchi et al. find that low-affinity EGFR ligands propagate faster and farther than high-affinity ligands in epithelial cells. They demonstrate that EREG, a low-affinity ligand, contributes to skin w...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...