Models (i.e., governing equations) are fundamental to science and engineering. Advances in data acquisition now make it possible to extract interpretable, low-dimensional descriptions from high-dimens...

Analysis of nearly 200 human gut microbiome datasets shows that microbial coexistence is governed by a few effective ecological dimensions, rather than the high-dimensional niches assumed by prevailing theory.

Emison et al. develop an information-theoretic framework that decomposes communication fidelity in gene regulatory networks. Applying this framework to single-cell RNA-seq data across aging tissues, they find that communication fidelity declines, driven primarily by shifting input distributions rather than increased channel noise.

Deguchi et al. find that low-affinity EGFR ligands propagate faster and farther than high-affinity ligands in epithelial cells. They demonstrate that EREG, a low-affinity ligand, contributes to skin w...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Generative models are extremely popular in modern biology. They have been used to model the variation of protein sequences, entire genomes, and RNA sequencing profiles. Importantly, generative models ...

Eukaryotic cells chemosense concentration gradients of extracellular ligands using membrane-bound receptors that polarize their activity. Receptors from several chemosensing families are preferentiall...