Pau Pascual @paupascual.bsky.social · 09/09/2026New paper from the Capelson Lab in collaboration with the @ranganlab.bsky.social where they found that Nup93-2 only partially overlaps with mature NPCs. This off-pore Nup pool helps silence Polycomb domains. 🤩https://www.biorxiv.org/content/10.64898/2026.08.28.747911v1biorxiv.orgDistinct functions of Nup93 paralogs in tumor growth and Polycomb-mediated repression of JAK/STAT signalingNuclear pore complexes (NPCs) are nuclear envelope (NE)-embedded protein assemblies that mediate nucleocytoplasmic exchange and interact with the genome, including binding of an NPC component Nup93 to... 065
Pau Pascual @paupascual.bsky.social · 08/05/2026His voice was the soundtrack to nature documentaries I grew up loving. 100 years of David Attenborough. Few scientists or communicators have done more to connect the public with the stakes of biodiversity and climate. Beautiful Nature's editorial @nature.com www.nature.com/articles/d41...nature.comHappy 100th birthday David Attenborough! Nature salutes youThe science communicator has raised awareness of the natural world andits myriad interconnections on which humans depend. 020
Reposted by Pau PascualMie Monti @miemonti.bsky.social · 04/03/2026New preprint from @novoalab.bsky.social ! Which tRNAs are used by ribosomes during translation? We introduce tRIBO-seq, a nanopore method to sequence ribosome-associated tRNAs and track how the active tRNA pool changes across stress conditions. www.biorxiv.org/content/10.6... Thread 👇 23713
Reposted by Pau PascualRangan Lab @ranganlab.bsky.social · 16/02/2026New preprint in collab with Capelson & Schindler labs): Nuclear pore complexes are developmentally removed and rebuilt during oocyte specification. Blocking turnover prevents gene silencing and meiotic entry. Nuclear architecture renewal is required for cell fate. www.biorxiv.org/content/10.6...biorxiv.org 097
Pau Pascual @paupascual.bsky.social · 20/12/2025It is always delightful to read Juan Valcarcel's thoughts. A very well-deserved Carmen y Severo Ochoa awardee and, even better, a colleague from whom we all learn in seminars and talks. @crg.eu elpais.com/ciencia/2025...elpais.comJuan Valcárcel, biólogo molecular: “Cada uno de nosotros es una experiencia única. ¿Qué sentido tiene clonarnos?”“Una forma de vida sintética no se ha producido aún, que yo sepa, pero no hay ninguna razón por la que no se pueda producir”, dice el científico, premio Carmen y Severo Ochoa de Investigación 020
Pau Pascual @paupascual.bsky.social · 04/12/2025Great news in these important days to fight #HIV infection that has taken the life of so many and caused stigma and discrimination. 010
Pau Pascual @paupascual.bsky.social · 04/11/2025POM121 is one of the transmembrane nucleoporins that anchors the Nuclear Pore to the nuclear envelope. The Rodriguez-Bravo+labs identified a nuclear-soluble pool of POM121 that enhances the aggressiveness of prostate cancer, offering new therapeutic opportunities for this disease. shorturl.at/Z2Kedaacrjournals.orgOff-pore Nucleoporin sPOM121 Transcriptionally Propels β-Catenin–driven Tumor Progression and Immune Escape in Prostate CancerTranscriptional reprogramming, mediated by off-pore, nucleoplasm-localized sPOM121, leads to therapy resistance and immune evasion and represents a vulnerability to β-catenin inhibition in prostate ca... 000
Reposted by Pau PascualCentre de Regulació Genòmica (CRG) @crg.eu · 23/10/2025Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you. More info: www.crg.eu/en/content/t... 12528
Pau Pascual @paupascual.bsky.social · 28/09/2025Really cool read - 'New generation of cancer-preventing vaccines could wipe out tumors before they form | Science | AAAS' www.science.org/content/arti...science.orgNew generation of cancer-preventing vaccines could wipe out tumors before they formShots enter early clinical trials for healthy people at high risk for disease 010
Reposted by Pau PascualWhitehead Institute @whiteheadinstitute.bsky.social · 08/09/2025Whitehead Institute honors the life and legacy of Nobel Laureate David Baltimore (1938–2025), its Founding Director and a globally revered scientific leader. 1/4 lnkd.in/eUKd4zxh 1103
Pau Pascual @paupascual.bsky.social · 09/07/2025Great news, providing access to CRISPR therapy for rare diseases in children is giving hope to many families chanzuckerberg.com/newsroom/cen...chanzuckerberg.comAdvancing Cures for Rare DiseasesWith the launch of the new center, we're one step closer to making personalized CRISPR cures a reality for children born with rare genetic diseases. 020
Pau Pascual @paupascual.bsky.social · 06/07/2025How are some enhancers able to regulate genes over megabase distances when they usually act in genes over kilobase distances? This is about a cis-element that helps enhancers to increase substantially their genomic interaction capacity.. Cool! www.nature.com/articles/s41...nature.comRange extender mediates long-distance enhancer activity - NatureThe REX element is associated with long-range enhancer–promoter interactions. 000
Reposted by Pau PascualArc Institute @arcinstitute.org · 23/06/2025Introducing Arc Institute’s first virtual cell model: STATE 1186
Reposted by Pau PascualCentre de Regulació Genòmica (CRG) @crg.eu · 11/02/2025💜Feliz #11F y #DíadelaMujeryNiñaEnLaCiencia💜lavanguardia.comEl 8-M de las científicas: miles de mujeres se vuelcan para despertar vocaciones en la niñasUn movimiento imparable ha arrancado con fuerza: es el sigiloso 8-M de las científicas. Mujeres determinadas a enseñar a las chicas que pueden ser profesionales capaces 0247
Pau Pascual @paupascual.bsky.social · 04/02/2025Today is #WorldCancerDay, a time to support those impacted, honor the memories of loved ones we've lost, and reflect on the important work we, as scientists, do. This year's message, #CloseTheCareGap," reminds us that equitable access to cancer care is not just a goal; it's a necessity. 030
Pau Pascual @paupascual.bsky.social · 26/01/2025This is such a step forward! Kudos to the authors. KRAS is mutated in around 25% of cancers and was considered “undruggable”, being this a good example of how the drug discovery field is being changed quickly with new computing tools and power. Hopefully the impact to patients arrives also soon! 🚀 000
Pau Pascual @paupascual.bsky.social · 04/12/2024Great time with friends and colleagues in our annual retreat of the Di Croce lab north of Barcelona #CRG 043
