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These 2 works challenge the idea that fungal biology can be reduced to 1 biomarker or isolated compound & underscore the need for a systems-level understanding of mycelium to unlock its functional potential. Proud of our R&D Team & grateful to everyone advancing our understanding of these #fungi 5/5

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This builds on our recent “Calm Under Challenge” study of lion’s mane mycelium, where we found that #mycelium can help keep the #ImmuneSystem cool under stress, while highly concentrated β-glucan fruiting body extracts produced a divergent response associated w/ overstimulation & imbalance. 4/5

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Adaptive Resilience: Agarikon Mycelium Modulates Immune Responses and Provides Oxidative Stress Buffering in Human Immune Cells

2️⃣ Accepted by Frontiers in Immunology, demonstrates context-dependent immune modulation by agarikon in human imm. cells. It explores potential mechanisms underlying agarikon’s centuries-long ass. w/ vitality & longevity, incl. key oxidative #StressDefensePathways www.biorxiv.org/content/10.6... 3/5

biorxiv.org

Agarikon ( Fomitopsis officinalis , syn. Laricifomes officinalis ) is a fungus with millennia of traditional use across many cultures with modern research supporting the antimicrobial, antiviral, anti...

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Genomic Characterization of the Endangered Medicinal Polypore Agarikon (Laricifomes officinalis syn. Fomitopsis officinalis)

1️⃣ Accepted by G3, the 1st annotated genome of #agarikon, revealing 27+ biosynthetic gene clusters ass. w/ diverse classes of bioactive compounds. We're applying this framework across our library of 120+ agarikon isolates, incl. 118 w/ complete #genomesequences www.biorxiv.org/content/10.6... 2/5

biorxiv.org

Agarikon ( Laricifomes officinalis syn. Fomitopsis officinalis ) is an endangered fungus belonging to a unique lineage in the Polyporales (Basidiomycota) with a growing body of evidence supporting its...

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Paul Stamets @paulstamets.bsky.social · 23/09/2026

Last month marked a major milestone in our mission to conserve, study & unlock the mycelial potential of #agarikon, one of the world’s most extraordinary fungi. Our R&D Team had 2 manuscripts accepted on the same day, advancing our understanding of agarikon from genetics to functional biology. 1/5

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Got a lot of bemused looks walking through the airport. “You have magic,” one person said. Indeed I do! Even airport security seems happy to see this giant #LibertyCap ! Follow the artist on Instagram to order one for yourself (coming soon). www.instagram.com/m_keyhole/ 📹 by Pamela Kryskow

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Paul Stamets @paulstamets.bsky.social · 16/09/2026

Thank you to the World Ayahuasca Forum for creating this space for dialogue, and to everyone who joined me for my talk. Ending in a standing ovation was a moment I will never forget… Video courtesy of Ancient Future Labs Learn more about the World Ayahuasca Forum: www.ayahuasca2026.com 3/3

ayahuasca2026.com

World Ayahuasca Forum | FÒRUM MUNDIAL DE L'AYAHUASCA

The World Ayahuasca Forum responds to the urgent call of Indigenous Spiritual Leaders for a deep intercultural dialogue between ancestral and Western knowledge systems. In these times of unprecedented...

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Paul Stamets @paulstamets.bsky.social · 16/09/2026

This gathering was a great example of “two-eyed seeing,” bringing Indigenous and scientific ways of knowing together through mutual respect and collaboration. 2/3

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Paul Stamets @paulstamets.bsky.social · 16/09/2026

Deeply grateful to have been invited by Elder Nixiwaka to speak at #Ayahuasca Forum, where Indigenous knowledge keepers led the way & gave scientists a seat at the table and a place at the podium. There was a powerful sense of urgency around protecting #Indigenous knowledge, practices & lands. 1/3

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Paul Stamets @paulstamets.bsky.social · 12/09/2026

The potential of #psilocybin continues to surprise us! 🆕research has found that psilocybin prevented #chemotherapy -induced peripheral neuropathy #CIPN in mouse models, a painful & often irreversible side effect of #cancer treatment for which there is currently no proven preventive strategy. 1/2

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Paul Stamets @paulstamets.bsky.social · 05/08/2026

...& even be genetically programmed w/ new functions. This research expands what’s possible w/ mycelium. From self-healing textiles & biodegradable products to env. biosensors & regenerative design, potential applications are vast. Imagine what comes next! www.science.org/doi/10.1126/sciadv.aed6937

science.org

A programmable fungal platform for engineered living textiles

A programmable fungal platform enables engineered living textiles with tunable functions and biodegradability.

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Paul Stamets @paulstamets.bsky.social · 05/08/2026

Scientists have developed a groundbreaking 🆕 type of living textile made from fungal #mycelium that remains alive after it’s manufactured. Unlike traditional mycelium-based materials, these engineered textiles retain living #FungalCells This allows them to sense their environment, self-renew, 1/2

science.org

A programmable fungal platform for engineered living textiles

A programmable fungal platform enables engineered living textiles with tunable functions and biodegradability.

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• 7 nights, 8 days aboard the Iberostar Grand Amazon — private-balcony cabins, fresh organic meals, unlimited beverages & full access to pools, jacuzzi, lounges, theater, gym & spa Only 100 places aboard — they’re going fast. Don’t miss this, link below to book. Operated by insiderexpeditions 5/6

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• Nocturnal excursions into the rainforest’s hidden, after-dark ecosystems • Live music and sound experiences under the stars • Talks and conversations on Indigenous wisdom, ancient medicines, psychedelic science, and the health of people and planet 4/6

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Here’s what’s waiting for you: 7 nights, 8 days: • 2 daily expeditions by boat and on foot through remote waterways & forest trails • Wildlife encounters — pink river dolphins at sunset, piranha in their natural habitat • Cultural exchange w/ Indigenous leaders & a visit to a local community 3/6

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The Amazon is the largest living network on the planet — a vast, breathing web of fungal & ecological intelligence. A teaspoon of Amazonian soil can hold 400+ species of fungi, and barely 2% have ever been identified. I’ll be there w/ Dr. Rick Doblin, Dr. Pam Kryskow, Indigenous elders & more. 2/6

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Paul Stamets @paulstamets.bsky.social · 14/06/2026

This November, I’m heading deep into the Amazon. We’re celebrating 40 years of MAPS — bringing psychedelics into medicine & healing. 7 nights aboard a ship on the waters of the Brazilian rainforest, where Indigenous wisdom keepers, ancient medicines & cutting-edge psychedelic science converge. 1/6

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Took a little trip off the beaten path after Mountain Games Vail with Chris Benchetler and friends! Wishing everyone a wonderful Sunday and a chance to get outside this weekend. 🚲🌲

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Paul Stamets @paulstamets.bsky.social · 12/06/2026

#Alzheimer’s disease affects millions of families worldwide and current treatment options remain limited. Findings like this help expand our understanding of what may be possible through #psilocybin research. Read more: www.thefocalpoints.com/p/new-study-...

thefocalpoints.com

NEW STUDY: Advanced Alzheimer’s Patient Regained Speech, Memory, and Bladder Control After a Single Psilocybin Dose

An 80-year-old woman with advanced Alzheimer’s — who had barely spoken for years — experienced rapid and sustained improvement after taking 5g of psilocybin mushrooms.

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Paul Stamets @paulstamets.bsky.social · 12/06/2026

For years, scientists have been studying #psilocybin’s ability to promote #neuroplasticity & stimulate 🆕 patterns of neural connectivity. If these mechanisms help the brain access pathways that have become dormant/disconnected, the implications for #neurodegenerative diseases could be profound. 2/3

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Paul Stamets @paulstamets.bsky.social · 12/06/2026

More amazing news has emerged from the world of #psilocybin research! A newly published case report describes an 80 year old woman with advanced #Alzheimer’s disease who reportedly experienced significant cognitive & functional improvements following a single high-dose psilocybin intervention. 1/3

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Paul Stamets @paulstamets.bsky.social · 03/06/2026

My daughter LaDena Stamets has launched her skincare line You Are Beautiful Skin Care. I couldn’t be more proud! Using botanical oils, antioxidants & mycelium from Fungi Perfecti, she created water-free formulations to support the skin’s natural barrier w/ concentrated, intentional ingredients. 1/2

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Paul Stamets @paulstamets.bsky.social · 24/05/2026

Viruses are spreading globally, and nature may hold more answers than we realize. In my latest Substack, I explore the growing interest in #polypore #mycelium and its potential role in supporting resilience in a rapidly changing world. Read more on my Substack: paulstamets.substack.com

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The findings add to a growing body of peer-reviewed work examining mycelium in real-world research contexts. 🔗 fungi.com/blogs/press-... *These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease 2/2

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#Mycology and the science behind its benefits continues to evolve. That's where our research team comes in.* Our latest clinical research explores #mushroom #mycelium grown on organic brown rice and its role in benefiting #humanhealth .* 1/2

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For those wanting to learn more, please explore my books Growing Gourmet and Medicinal Mushrooms and Mycelium Running: How Mushrooms Can Help Save the World. Get your copies at www.fungi.com. Filming by Pamela Kryskow 3/3

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Fungi Perfecti® is a family-owned, environmentally friendly company specializing in using mushrooms to improve the health of the planet and its people. Founded by mycologist and author Paul Stamets in...

One of the reasons I enjoy cooking with oyster #mushrooms is their remarkable ability to absorb the flavors of whatever you prepare them with. I’d love to hear from fellow #myconauts. What are your favorite oyster mushroom recipes? Please share them in the comments. 2/3

fungi.com

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