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Reposted by Paul Lapios 🧘‍♂️

EMBO @embo.org · 26/03/2025

Learn principles of image processing to determine macromolecular structures by #cryoEM: Sign up for EMBO Practical Course on Image processing for cryo-electron microscopy in London, UK, 9–16 September Deadline: 25 April meetings.embo.org/event/25-cry... #EMBOcryoEM #EMBOevents 🧪

meetings.embo.org

Image processing for cryo-electron microscopy

Cryo electron microscopy (cryo EM) is a major structural biology method for studying macromolecular complexes and cellular structures in their native states. Stable high resolution cryo microscopes, …

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Reposted by Paul Lapios 🧘‍♂️

Nature @nature.com · 11/03/2025

A new chapter has begun for two of the world’s most popular preprint platforms, bioRxiv and medRxiv, with the launch of a non-profit organization that will manage them go.nature.com/4iCVnHL

go.nature.com

Preprint sites bioRxiv and medRxiv launch new era of independence

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Reposted by Paul Lapios 🧘‍♂️

Jana Kroll @janakroll.bsky.social · 12/02/2025

Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1... We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️

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Reposted by Paul Lapios 🧘‍♂️

David Perrais @davip-bdx.bsky.social · 10/02/2025

New preprint from the MemTraS team ! www.biorxiv.org/content/10.1... Great collaboration with @fronzeslab.bsky.social and Vladan Lucic to determine the first cryo electron tomography images of dopamine "synapses" extracted from adult mouse brain.

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Reposted by Paul Lapios 🧘‍♂️

Rémi Fronzes @fronzeslab.bsky.social · 10/02/2025

This study was key to establishing #cryoCLEM and #cryoET in Bordeaux. It is an important milestone. @davidp-bdx.bsky.social, Étienne Herzog and @paulosh.bsky.social took the risk to be the first to use this approach with us. 🙏🙏🙏

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Paul Lapios 🧘‍♂️ @paulosh.bsky.social · 12/02/2025

Very happy to share our last preprint where we investigated the vesicular organization of dopamine hub synapses with cryo-CLEM. It is a brain structure that emerges as an important regulator of striatal activity. Many thanks to David Perrais, Etienne Herzog and the lab of @fronzeslab.bsky.social !

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Reposted by Paul Lapios 🧘‍♂️

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 08/02/2025

Cryo-correlative light and electron tomography of dopaminergic axonal varicosities reveals non-synaptic modulation of cortico-striatal synapses www.biorxiv.org/content/10.1101/202…

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