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Paula Haynes

@paulahyns.bsky.social
658 followers 635 following 9 posts

🔬🧬🧪🧠👩‍🔬 Instructor, MGH-Boston | neuron-glia lipid and mitochondrial metabolism in sleep and memory consolidation, APOE, Alzheimer's, Drosophila and mice scholar.google.com/citations?user=I…

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Paula Haynes @paulahyns.bsky.social · 25/01/2025
This is interesting, but likely only the tip of the iceberg because normally inhibiting complex1 is NOT a good thing: it causes electron leak and massive oxidative damage. And it also does not normally feedback on glucose levels. www.science.org/doi/10.1126/...
science.org
Metformin targets mitochondrial complex I to lower blood glucose levels
Acute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I.
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Reposted by Paula Haynes
Alexey Amunts @amunts.bsky.social · 20/12/2024
The link between mitochondrial bioenergetics and brain aging reported in Science. A beautiful study by our neighbours, Huan Ma lab demonstrates that restoring excitation-transcription coupling in mitochondria can improve memory function. This has a potential to reverse age-related cognitive decline.
science.org
Aged neurons don’t register energy need
Neuronal activity and mitochondrial gene expression become decoupled in aged mice
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Reposted by Paula Haynes
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 14/11/2024
Out today @NatureAging! Life stress can accelerate aging and shorten lifespan, but how remains unclear. We identify that hippocampal/cortical neurons acquire features of p16-dependent #senescence and DNA damage in mice exposed to chronic social stress. Lyons et al. doi.org/10.1038/s435...
doi.org
Chronic social stress induces p16-mediated senescent cell accumulation in mice - Nature Aging
Exploring the molecular consequences of exposing mice to social stress, Lyons et al. identify that hippocampal and cortical neurons acquire features of senescence, identifying a mechanism through whic...
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Reposted by Paula Haynes
Joachim Goedhart @joachimgoedhart.bsky.social · 16/11/2024
Elucidating the spatiotemporal dynamics of glucose metabolism with genetically encoded fluorescent biosensors doi.org/10.1016/j.cr...
Cartoon of biosensors for Glucose
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Reposted by Paula Haynes
Beth Cimini 🔬💻📊 @bethcimini.bsky.social · 08/11/2024
Another starter pack of fine fine folks - New PIs! We're all figuring it out together! Please do (self-)nominate go.bsky.app/KJXNgfZ
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Reposted by Paula Haynes
Ian Harrison @ianharrisonneuro.bsky.social · 16/11/2024
Our latest preprint out on bioRxiv...we show that glymphatic function influences synuclein propagation in the brain 🧠
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CLaE @claeneuro.bsky.social · 15/11/2024
Science Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states www.science.org/doi/10.1126/...
science.org
Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states
Psychedelics hold promise as alternate treatments for neuropsychiatric disorders. However, the neural mechanisms by which they drive adaptive behavioral effects remain unclear. We isolated the specifi...
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Paula Haynes @paulahyns.bsky.social · 16/11/2024
Nedergaard lab- impaired increase of infra-slow (30s) norepinepherine-oscillations in APP/PS1 mice after sleep deprivation. Suggests Amyloid-β (or γ-secretase) may impair it's own glymphatic clearance... www.cell.com/cell-reports...
cell.com
Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model
Cankar et al. report that sleep loss suppresses NREM norepinephrine oscillations in a murine model of Alzheimer’s disease along with a parallel buildup of amyloid-β. Thus, overexpression of amyloid-β ...
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Ardem Patapoutian @ardemp.bskyverified.social · 15/11/2024
Super useful tool to import list of people you were following on Twitter to 🦋
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Mackenzie Weygandt Mathis @trackingactions.bsky.social · 12/11/2024
Woo hoo! 1K new followers, welcome to 💙🦋! For science-minded folks, there are some very cool tricks 🚀… If you use any of these emojis: 👩‍🔬|👩🏻‍🔬|👩🏼‍🔬|👩🏽‍🔬|👩🏾‍🔬|👩🏿‍🔬 your post will index on a Women in STEM feed If you use 🧪 a Science feed If you use 🧠 a Neuroscience feed Go get it 🚀🧪🧠👩‍🔬💙🎊
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Reposted by Paula Haynes
Sarah J. Jackson @sjjphd.bsky.social · 18/03/2024
This is a fantastic analysis from student journalists at Penn who have done a better job covering various interests, and the stakes, on our campus than many major media outlets have done all year…
34st.com
Donors Rule Everything Around Me
When money talks, professors are silenced.
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 18/02/2024
We often assume textbook depictions can capture all of the diversity seen in living things--spoiler--they don't. Here's a remarkable example: Mitochondria in neuronal axons lack DNA and don't generate ATP!!! 🧪 1/2 www.biorxiv.org/content/10.1...
Title and abstract from the link
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