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Parker Singleton

@parkersingleton.bsky.social
1.2K followers 233 following 116 posts

Senior Scientist at Penn Lifespan Informatics and Neuroimaging Center (PennLINC) studying psychedelics and the brain. sypres.io

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Reposted by Parker Singleton
Golia Shafiei @goliashf.bsky.social · 30/09/2026
So excited that our work is now published in PLOS Biology!! 🎉 Check out the final version here: doi.org/10.1371/jour... And for a bit more context and what we found, here’s our earlier thread: bsky.app/profile/goli...
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Brooke Sevchik @bsevchik.bsky.social · 20/08/2026
Very excited to announce that this work is now published in Scientific Data! doi.org/10.1038/s415...
doi.org
A longitudinal data resource to study brain development and transdiagnostic variation in executive function - Scientific Data
Scientific Data - A longitudinal data resource to study brain development and transdiagnostic variation in executive function
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Ted Satterthwaite @ted-satterthwaite.bsky.social · 07/07/2026
Awesome new work by @tsalo.bsky.social and @parkersingleton.bsky.social — a small but valuable test-retest dataset comparing single & multi-echo fMRI. Completely open + fully processed!!!!
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PennLINC @pennlinc.bsky.social · 07/07/2026
New dataset out in Data in Brief 🧠 We're releasing an open, test-retest neuroimaging dataset built for directly comparing single-echo vs. multi-echo fMRI, head-to-head, in the same people. 1/
sciencedirect.com
A single-echo/multi-echo BOLD fMRI test-retest dataset
Functional MRI (fMRI) remains one of the primary tools for non-invasive studies of brain activity and organization in humans. Recently, multi-echo ima…
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Parker Singleton @parkersingleton.bsky.social · 10/06/2026
curious to see how much that will have changed in a month
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Thomas Yeo @bttyeo.bsky.social · 22/05/2026
Here's bonus slides on cross-validation tests, separate from our preprint. Covering: 1. paired (sign-flip) permutation test 2. label-swap permutation test 3. sample-level vs fold-averaged stats 4. a common misapplication of the corrected t-test 5. three bootstrap variants 1/N
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Parker Singleton @parkersingleton.bsky.social · 30/04/2026
Nice article on our recent Nature Mental Health paper: www.medscape.com/viewarticle/...
medscape.com
‘Living’ Database Tracks Psilocybin Trials for Depression
Sypres.io continuously tracks and evaluates psychedelic research, offering an up-to date view of study findings, design, and limitations.
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Reposted by Parker Singleton
Corey Horien @coreyhorien.bsky.social · 25/04/2026
Thrilled to share our latest paper, out recently in Nature Mental Health. "Optimizing functional connectivity scanning conditions for predicting autistic traits" www.nature.com/articles/s44... 1/n
nature.com
Optimizing functional connectivity scanning conditions for predicting autistic traits - Nature Mental Health
This research investigates optimal brain states for predicting autistic traits using connectome-based predictive modeling across four datasets. Findings indicate that a sustained attention task enhanc...
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Evan Gordon @gordonneuro.bsky.social · 22/04/2026
I always assumed that brain function had to line up with cytoarchitectonics. It turns out I was wrong. Human cortex, especially PFC, is tiled by chains of functional patches that subdivide and interlink architectonic areas into parallel processing streams. www.biorxiv.org/content/10.6...
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Steven Meisler @stevenmeisler.com · 19/04/2026
Diffusion MRI (dMRI) is a powerful tool to study white matter maturation. In our new preprint, we process and distribute a new resource of >24,000 ABCD dMRI scans using open source tools! We then evaluate how methods shape inferences about development. 🔗 www.biorxiv.org/content/10.6...
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Parker Singleton @parkersingleton.bsky.social · 10/04/2026
this is amazing 🤣
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Ted Satterthwaite @ted-satterthwaite.bsky.social · 09/04/2026
Incredible work by the absolutely stellar @bsevchik.bsky.social and @parkersingleton.bsky.social — the second installment of our open-science living meta-analysis of psychedelics for mental health.
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Parker Singleton @parkersingleton.bsky.social · 08/04/2026
And here's our second installment of sypres.io, co-led by the brilliant @bsevchik.bsky.social !!
sypres.io
SYPRES
The official website for the sypres initiative.
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Manoj Doss not exist @manojdoss.bsky.social · 06/04/2026
This paper has been a long time coming. Instead of reanalyzing the same old resting-state fMRI datasets, we combined nearly all datasets around the world. Note that we didn't exactly find indisputable evidence for "default mode network disintegration." www.nature.com/articles/s41...
nature.com
An international mega-analysis of psychedelic drug effects on brain circuit function - Nature Medicine
Analysis of neuroimaging datasets across five major psychedelics revealed a shared brain signature and provides a comprehensive insight into how these drugs reorganize brain architecture.
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Ted Satterthwaite @ted-satterthwaite.bsky.social · 06/04/2026
Beyond delighted to see this paper -- our first from the SYPRES initiative -- now out at @natmentalhealth.nature.com. Check out Parker's awesome thread below, w/ links to dashboard + all code + data.
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Cobb Scott @jcobbscott.bsky.social · 06/04/2026
Excited that this is officially out there in the world. Check out the dashboard and visualizations! Huge shout out to Parker and Brooke, who led this herculean effort. More to come!
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Parker Singleton @parkersingleton.bsky.social · 06/04/2026
Huge shout out to co-first author @bsevchik.bsky.social, Analiese Lahey, @pimcuijpers.bsky.social, @mathiasharrer.bsky.social, @mntj21.bsky.social, Sandeep Nayak, Eric Strain, @vandyatvandy.bsky.social, Bob Dworkin, @jcobbscott.bsky.social, @ted-satterthwaite.bsky.social, @pennlinc.bsky.social
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Parker Singleton @parkersingleton.bsky.social · 06/04/2026
In partnership with metapsy.org we built an interactive dashboard for exploring the data. Users can: • Filter studies by characteristics • Test different analysis parameters • Test moderators • Download figures and reports Dashboard: metapsy.org/sypres/psilo...
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Parker Singleton @parkersingleton.bsky.social · 06/04/2026
Our database includes 200+ effect sizes, encompassing all depression outcomes and timepoints reported by arm in each of the 15 RCTs included. This database can be downloaded from our website (sypres.io) or imported directly into R environments using the metapsyData package.
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Parker Singleton @parkersingleton.bsky.social · 06/04/2026
Here, in our first SYPRES review, psilocybin showed a greater reduction in depression scores compared to control conditions, with a pooled Hedges’ g = -0.90. But important caveats—small studies, blinding challenges, risk of bias, and design heterogeneity, which we discuss in the paper.
Forrest plot of main meta-analytic model.
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Parker Singleton @parkersingleton.bsky.social · 06/04/2026
sypres.io is our new initiative featuring: 📊 Regularly updated meta-analyses 🔍 User-guided sensitivity and moderation analysis 🕵️ Transparent study quality & risk-of-bias assessments ⚙️ Open code & data
Screen shot of psilocybin for depression study page on sypres.io
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Parker Singleton @parkersingleton.bsky.social · 06/04/2026
Psychedelic science has experienced the benefits and drawbacks of hype. However, new results are rarely contextualized in the historical body of evidence in an accessible manner. We need more robust, living, evidence synthesis that is visible and accessible to all stakeholders.
Image of Gartner Hype Cycle
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Parker Singleton @parkersingleton.bsky.social · 06/04/2026
🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out now in Nature Mental Health. Here's what we found and the open science infrastructure we built to support it 🧵 Open-Access Link: rdcu.be/fbU5V
rdcu.be
A living systematic review, meta-analysis and open-data resource of randomized controlled trials of psilocybin treatment for symptoms of depression
Nature Mental Health - This study presents a living systematic review and open-data meta-analytic database from 15 randomized controlled trials examining the effects of psilocybin treatment on...
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Parker Singleton @parkersingleton.bsky.social · 06/04/2026
hello
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Parker Singleton @parkersingleton.bsky.social · 06/04/2026
boop
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Emmanuel A. Stamatakis @estamatakis.bsky.social · 27/03/2026
What makes brains (un)conscious? We provide new answers—and a universal mammalian blueprint for information processing—in a cross-species study of humans, macaques, marmosets & mice. Exploring convergent breakdown of integration in: www.nature.com/articles/s41... Led by @loopyluppi.bsky.social
nature.com
Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains - Nature Human Behaviour
Luppi et al. identify transcriptomic and connectomic controllers of information integration and its breakdown induced by anaesthesia in humans, macaques, marmosets and mice.
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Parker Singleton @parkersingleton.bsky.social · 19/03/2026
Happy to have been a part of yet another tour de force led by the one and only @loopyluppi.bsky.social !
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Roselyne Chauvin @roselynechauvin.bsky.social · 13/03/2026
The 6x US memory champion – Nelson Dellis – can memorize a deck of cards in 40 seconds and knows the first 10K digits of pi. To figure out how, he let us peak inside his brain. Here is what we learned in our precision brain mapping study www.biorxiv.org/content/10.6... youtube.com/shorts/MryMq...
youtube.com
how does his brain do it ? #neuroscience #memory #sport Nelson Dellis 6x US memory champion
YouTube video by Roselyne Chauvin
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Emily Finn @esfinn.bsky.social · 16/03/2026
Very happy that this paper from our lab is now out in @pnas.org! What happens when the *same* person experiences the *same* information with a *different* interpretation? Nearly the whole 🧠—well, at least nearly all association cortex—changes how it represents that information! tinyurl.com/p8chj2j7
tinyurl.com
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Caroline Nettekoven @carobellum.bsky.social · 10/03/2026
🧠 Resting-state fMRI is often treated as the gold standard for studying the brain’s intrinsic organization. But is it actually the best way to estimate functional architecture? We tested this directly. 🧵1/8
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Audrey Luo @audreycluo.bsky.social · 02/03/2026
We think of white matter as the highways of the brain. But when we followed development along those highways, we were surprised. The journey is more complex than we thought. My final PhD paper, “Two Axes of White Matter Development”, is now out in @natcomms.nature.com! 🛣️🧠✨ 🔗 bit.ly/wm2axes
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Parker Singleton @parkersingleton.bsky.social · 05/02/2026
Every participant had a MEQ-30 score of 150: youtu.be/-c9-poC5HGw?...
youtu.be
Africa - Angel City Chorale
YouTube video by Angel City Chorale
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Howard Chiu @howardchiu.bsky.social · 25/01/2026
My first preprint is out! Thank you to my brilliant collaborators & mentors for making this possible @vmarchman.bsky.social @arokem.org @jyeatman.bsky.social, as well as everyone behind the awesome open source software that we use @pennlinc.bsky.social @cieslakmatt.bsky.social (& many not on bsky)
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Rachel Ernst @rachelernst.myatproto.social · 05/01/2026
My Neighbour Totoro is I think the only movie I can think of that has a compelling plot for kids that does not involve a villain.
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Parker Singleton @parkersingleton.bsky.social · 05/01/2026
hahahah
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Parker Singleton @parkersingleton.bsky.social · 05/01/2026
Another important one for psychedelics fMRI ppl: www.biorxiv.org/content/10.6...
biorxiv.org
Physiological Arousal as a Predominant Source of Individual Differences in Functional Brain Networks
Individual differences in brain network function and organization are promising targets for fMRI-based biomarkers in precision psychiatry, yet the sources of individual variability remain poorly under...
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Parker Singleton @parkersingleton.bsky.social · 24/11/2025
Come join an amazing team where you're guaranteed to set yourself up for future success!
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Amy Kuceyeski @amykooz.bsky.social · 21/11/2025
💊 🍸 Risk for substance use disorder (SUD) rises in adolescence. Family history and biological sex play major roles in a person's level of SUD risk. New evidence suggests neural markers of SUD may exist before substance use starts - yet how these markers differ across sexes is not understood.
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Brooke Sevchik @bsevchik.bsky.social · 12/11/2025
🧠I am excited to announce that our manuscript introducing a new data resource – PennLEAD (Penn Longitudinal Executive functioning in Adolescent Development) – is now available on bioRxiv. Below are some details highlighting our data resource🧵funded by NIMH R01MH113550 www.biorxiv.org/content/10.1...
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Matt Cieslak @cieslakmatt.bsky.social · 11/11/2025
After years of development and testing, we are happy to present our work in "Diffusion MRI Processing in the HEALthy Brain and Child Development Study: Innovations and Applications"! www.biorxiv.org/content/10.1.... A thread:
biorxiv.org
Diffusion MRI Processing in the HEALthy Brain and Child Development Study: Innovations and Applications
The landmark ongoing HEALthy Brain and Cognitive Development (HBCD) study will longitudinally chart brain development in a large sample (projected n=7,200) of infants through age 10 years with multimo...
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Jason Luoma, Ph.D. @jasonluoma.bsky.social · 27/10/2025
Strongest data yet suggesting that repeated MDMA use causes deficits in declarative memory (e.g., memory for new information, words, etc). #psychedelicscience #MDMA 10.1093/brain/awaf391
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Parker Singleton @parkersingleton.bsky.social · 20/10/2025
I thought about busting the PS out of the attic recently just for Spyro and Crash Bandicoot
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Parker Singleton @parkersingleton.bsky.social · 20/10/2025
Hot off the press!
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Jonah Padawer-Curry, PhD @jonahpadawercurry.bsky.social · 15/10/2025
🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging. 👇🧵 nature.com/articles/s41... #Neuroscience #Psychedelics #BrainImaging
nature.com
Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function
Nature Neuroscience - Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI...
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Parker Singleton @parkersingleton.bsky.social · 14/10/2025
If you agree to review a paper, you should send it in on time. You're holding a spot and slowing up the whole process if you don't.
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Esther Schindler @estherschindler.bsky.social · 06/10/2025
I just saw someone use the abbreviation “AI;DR” and I’ll be laughing for a while.
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Parker Singleton @parkersingleton.bsky.social · 24/09/2025
Amazing stuff here from @goliashf.bsky.social and the RBC team! Harmonized and curated imaging and phenotype data from over 6,000 youth easily accessible without any DUA. Check it out.
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Ted Satterthwaite @ted-satterthwaite.bsky.social · 07/09/2025
New preprint from stellar IRTG PhD student Amelie Rauland + team on white matter bundle reconstruction! Shows that WM bundles can be reliably extracted from simple 32-direction dMRI & features predict cognition - huge potential for legacy and clinical data. Thread 👇 www.biorxiv.org/cgi/content/...
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Parker Singleton @parkersingleton.bsky.social · 28/08/2025
my linkedin feed has become filled with psychedelic memes and I'm connected with an OG acid kingpin.
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Parker Singleton @parkersingleton.bsky.social · 26/08/2025
I'm near certain sLFOs are big for psychedelics.
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