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Pagès lab

@pageslab.bsky.social

545 followers 191 following 9 posts

DNA damage and genome instability group Cancer Research Center of Marseille. #DNAdamage, #TranslesionSynthesis, #HomologousRecombination, in bacteria & yeast

Posts Replies Media

Pagès lab @pageslab.bsky.social · 14/11/2025

Exciting opportunity: we are hiring a postdoctoral fellow for a fully funded 2-year position!

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Pagès lab @pageslab.bsky.social · 05/11/2025

Amazing view from the 24th floor of the Sorbonne tower at the 7th German-French DNA Repair Meeting! Excited to give my talk tomorrow!

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Pagès lab @pageslab.bsky.social · 12/09/2025

open access version here: hal.science/hal-05250217

hal.science

The RecBC complex protects single-stranded DNA gaps during lesion bypass

Following encounter with an unrepaired DNA lesion, replication is halted and can restart downstream of the lesion leading to the formation of a single-stranded DNA (ssDNA) gap. To complete replication...

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Pagès lab @pageslab.bsky.social · 12/09/2025

New paper out! We show that RecBC remodels single-stranded DNA gaps to protect them from ExoI (sbcB) 3′-5′ exonuclease degradation during replication of damaged DNA. doi.org/10.1073/pnas...

doi.org

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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Reposted by Pagès lab

CNRS Biologie @cnrsbiologie.bsky.social · 11/04/2025

#RésultatScientifique 🔎 Découvrez la dernière publication de Vincent Pagès et de ses collaborateurs ! 🤝 @cnrs-dr12.bsky.social @insermpacacorse.bsky.social @univ-amu.fr @paoli-calmettes.bsky.social @pageslab.bsky.social @crcm.bsky.social 👉 @narjournal.bsky.social buff.ly/rVeGV9B

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Pagès lab @pageslab.bsky.social · 25/03/2025

Thanks Annabel!

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Pagès lab @pageslab.bsky.social · 24/03/2025

Our key findings: -DNA polymerase η swiftly bypasses UV-induced lesions at the replication fork. -Post-replicative gaps allow Translesion Synthesis (TLS) to compete with Damage Avoidance (DA), reducing mutagenicity. -Gap extension by Exo1 nuclease favors DA and reduces TLS

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Pagès lab @pageslab.bsky.social · 24/03/2025

Our latest article, in collaboration with Helle Ulrich, explores how the timing of lesion bypass and gap processing impacts genome stability. doi.org/10.1093/nar/...

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Pagès lab @pageslab.bsky.social · 25/02/2025

How does Pol IV overcome strong replication blocks in E. coli? Our latest study with @joeloparo.bsky.social uncovers a bipartite clamp interaction that helps Pol IV compete with Pol III, enabling efficient TLS at stalled forks and reducing mutagenesis. buff.ly/3Xbgjxd

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Pagès lab @pageslab.bsky.social · 17/12/2024

Recruiting a postdoc to work on our yeast project

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