A human-targeted drug selects for drug-resistant Pneumocystis jirovecii strains that drive global transmission and outbreaks in transplant recipients.

Author summary Pneumocystis jirovecii is a fungal pathogen causing pneumonia in immunocompromised humans. Infections by P. jirovecii are treated using drugs that prevent this pathogen from making fola...

The clinical significance of detection of Pneumocystis jiroveci in immunocompetent children with LRTI should be further investigated, and specific therapy could be considered individually based on cli...

Why are there so few pathogens, and what determines their emergence? This Perspective argues that ecological and evolutionary forces (host availability, geographic exposure and microbial innovation) w...

Pneumocystis species are obligate fungal pathogens that cause severe pneumonia, particularly in immunocompromised individuals. The absence of robust genetic manipulation tools has impeded our mechanis...

Join me on Cosmic Radio as we speak with Dr. Joseph Heitman. Dr. Heitman is a professor and Chair of Molecular Biology and Professor in Medicine at Duke University and CIFAR's Co-Director for the "Fun...

SUMMARYEvery human being is presumed to be infected by the fungus Pneumocystis jirovecii at least once in his or her lifetime. This fungus belongs to a large group of species that appear to exclusivel...

Pneumocystis species are host-obligate fungal pathogens that cause severe pneumonia in immunocompromised individuals. Despite their clinical importance, their life cycle remains poorly understood, in ...

Pneumocystis jirovecii pneumonia (PCP) is a leading cause of fungal pneumonia, but its diagnosis primarily relies on invasive bronchoalveolar lavage (BAL) specimens that are difficult to obtain. Oroph...

Early-life lung microbiota is dynamic, with major shifts at 3–4 months. Transient microbes dominate, but some persist, influencing lung health. Pneumocystis jirovecii may be a key driver of microbial ...

The fungus Pneumocystis causes severe pneumonia in patients with weakened immune systems. It possesses a genetic system to vary the antigens at the surface of its cells that are presented to the immun...

As a landmark WHO report warns of a lack of treatments and diagnosis, we investigate a threat that now kills twice as many people as TB