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Vilja Oired

@oired.bsky.social
2K followers 1.8K following 116 posts

News, info, ideas & comments on medicine, health care, geriatrics, tech and more.

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Vilja Oired @oired.bsky.social · 28/02/2026
Not AI, or maybe it is … - at minimum a new way to explore symptoms 😘
oired.com
Oired
Introducing Oired, a symptom checker designed with the elderly in mind
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Vilja Oired @oired.bsky.social · 01/12/2025
”Plasma measures of p-tau217 can accurately identify individuals in the preclinical stage of Alzheimer disease where interventions are likely to have the most benefit in delaying or stopping disease progression.”
jamanetwork.com
Plasma p-Tau217 and Amyloid Burden in Older Adults Without Cognitive Impairment
This meta-analysis examines data for the accuracy of plasma phosphorylated tau 217 tests from published studies that compared older adults without cognitive impairment who were amyloid positive vs amy...
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Vilja Oired @oired.bsky.social · 09/11/2025
An implant that cures blindness, fantastic news for AMD patients! This could bring bionic sight within reach.
nature.com
People with blindness can read again after retinal implant
An electronic eye implant has restored vision in people with blindness caused by age-related macular degeneration.
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Filmfreak Mafia @filmfreakmafia.mastodon.social.ap.brid.gy · 02/11/2025
'The Pitt' Has Inspired More Organ Donation and End-of-Life Planning | Michael Schneider for Variety (@Variety) variety.com/2025/tv/news/the-pitt-o…
variety.com
‘The Pitt’ Has Inspired More Organ Donation and End-of-Life Planning, According to USC Norman Lear Center Study
After just one season, Emmy-winning drama “The Pitt” is already having an impact on healthcare conversations. That’s the finding from a new study released Monday by the USC Norman Lear Center, which said “The Pitt” has shifted the conversation on issues such as organ donation and end-of-life planning. According to a group of 1,409 viewers […]
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American Academy of Hospice and Palliative Medicine @aahpm.bsky.social · 30/10/2025
A landmark moment for palliative care research! Discover the long journey that led to this breakthrough and why it matters for patients and clinicians. Read the full blog here: ow.ly/k31F50XkpUv
ow.ly
A Long Road to a Landmark Moment in Palliative Care Research | AAHPM
Kyle P. Edmonds, MD FAAHPM Clinical Professor at UC San Diego Health Sciences Health Policy Strategic Coordinating Commitee Chair When I first walked the halls of Capitol Hill in 2013 […]
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Vilja Oired @oired.bsky.social · 01/10/2025
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Vilja Oired @oired.bsky.social · 05/07/2025
Interesting🤔
ox.ac.uk
How do vaccines reduce the risk of dementia? | University of Oxford
A new study by the University of Oxford, published in the journal npj Vaccines, shows that a vaccine against respiratory syncytial virus (RSV) is associated with a 29% reduction in dementia risk in
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Vilja Oired @oired.bsky.social · 03/06/2025
Robotic surgery outperforms laparoscopic in rectal cancer. Next step: train robots using AI like that in self-driving cars and humanoids. How long before an AI-driven robot beats the surgeon-controlled one?
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Vilja Oired @oired.bsky.social · 23/05/2025
Excess death in US compared to other high-income countries. This trend can probably only be broken by the Ozempic-pandemic🤔 and maybe some sensible healthcare reforms💡.
jamanetwork.com
Excess US Deaths Before, During, and After the COVID-19 Pandemic
This cohort study examines trends in excess deaths in the US before, during, and after the COVID-19 pandemic.
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Vilja Oired @oired.bsky.social · 23/05/2025
Superhuman performance of a large language model on the reasoning tasks of a physician. arxiv.org/abs/2412.10849
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Journal of the American Geriatrics Society (JAGS) @agsjournal.bsky.social · 16/05/2025
Hospitalized patients with dementia are infrequently present in GOC conversations and less likely to have their values and preferences for medical care documented within a GOC note. #geriatrics #palliativecare agsjournals.onlinelibrary.wiley.com/doi/10.1111/...
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Vilja Oired @oired.bsky.social · 15/05/2025
Human(?) development is about to jump to hyperspace. With small tweaks, this could be applied to everything from scientific research to factory floors and logistics.
nature.com
DeepMind unveils ‘spectacular’ general-purpose science AI
System improves chip designs and tackles unsolved maths problems, but has not been rolled out to researchers outside the company.
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NEJM.org @nejm.org · 11/05/2025
“Our study demonstrated associations between obesity, particularly severe obesity, and the incidence of 16 common health outcomes.” 📋 Read the full study results by Z. Yao et al. in NEJM Evidence: eviden.cc/4iIRjGg #MedSky #EndoSky
A graph showing the adjusted population-attributable fraction of obesity classes for prevalent health conditions
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AHA Science @ahascience.bsky.social · 21/04/2025
Heart and Kidney disease are related. Many patients have both, leading to CKM syndrome. spr.ly/6048uP0fo As many as 9 in 10 adults with CKD don't know they have it. Kidney disease usually has 0 symptoms, & many people don’t know they have it until it’s very advanced.
KDIGO heat map for CKD classification.
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Mikael Ehrnström @mickeehrnstrom.bsky.social · 15/04/2025
Symptom support, unbiased and pure. Taking on the toughest cases: elderly patients. Get diagnoses and suggested investigations. Powered by our own AI (not Big Tech), but we use LLM as a sidekick. Easy, no login, free to use: Oired.com
oired.com
Oired
Introducing Oired, a symptom checker designed with the elderly in mind
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Reposted by Vilja Oired
NEJM.org @nejm.org · 13/04/2025
In the API-CAT trial involving patients with active cancer and venous thromboembolism, extended anticoagulation with reduced-dose apixaban was noninferior to full-dose apixaban for preventing recurrent thromboembolic events. Full trial results and Research Summary: nej.md/41YkRZK #MedSky
The New England Journal of Medicine    
Extended Reduced-Dose Apixaban for Cancer-Associated VTE 
A Research Summary based on Mahé I et al. | 10.1056/NEJMoa2416112 | Published on March 29, 2025 

Visual representations of the patients in the trial and the treatments they were assigned.        

Read the full Research Summary at NEJM.org.
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Vilja Oired @oired.bsky.social · 08/04/2025
In Type 2 Diabetes SLGT2 decreased risk of Alzheimer with 43% and GLP-1 with 33% compared with other DM2 medications. No significant difference between SLGT2 and GLP-1. jamanetwork.com/journals/jam...
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Vilja Oired @oired.bsky.social · 07/04/2025
Read, learn, think and challenge yourself should be added throughout life.
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Vilja Oired @oired.bsky.social · 02/04/2025
Zoster vaccine reduced the probability of a new dementia diagnosis by approximately 20% over a seven-year follow-up period.
nature.com
A natural experiment on the effect of herpes zoster vaccination on dementia - Nature
Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...
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Vilja Oired @oired.bsky.social · 01/04/2025
”On average, each dollar spent on vaccination yields a hefty $54 in returns.” - That is a good investment!
economist.com
First, jab more babies
As aid shrinks, donors and recipients should focus more on health
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Vilja Oired @oired.bsky.social · 01/04/2025
NEJM: Global Effect of Cardiovascular Risk Factors on Lifetime Estimates. With all 5 risk factors (high blood pressure, high cholesterol, diabetes, smoking, and unhealthy body weight) at age 50 lifetime cardiovascular disease risk was 38% in men and 24% in women. www.nejm.org/doi/full/10....
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Vilja Oired @oired.bsky.social · 01/04/2025
Treating coronary artery disease risk factors early could make it a rare disease. But are we ready to take pills to prevent a disease that might occur 40 years later? Of course, a middle way already exists in clinical practice. However, this Lancet Commission rightly highlights prevention.
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Vilja Oired @oired.bsky.social · 26/03/2025
About to retire, prepare yourself or risk cognitive decline.
nytimes.com
Retirement Can Harm Your Brain. Here’s How to Keep It Healthy.
It’s challenging to stay mentally sharp and healthy through the major transition. Careful planning is key.
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Vilja Oired @oired.bsky.social · 25/03/2025
The number of geriatricians is shrinking, just 7,400 in 2022, down from 10,000 in 2000, while the aging population keeps growing. The American Geriatrics Society says we’ll need 30,000 by 2030. The math isn’t adding up!
businessinsider.com
America's aging population faces a growing shortage of geriatric care
For a variety of reasons, geriatric care experts told BI it's been hard attracting new doctors to the field. It's a problem for an aging US population.
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Eric Topol @erictopol.bsky.social · 23/03/2025
A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved
graph of NIH basisfor new drugs
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Ian Kremer @wolverinebear.bsky.social · 24/03/2025
#Kindness cannot prevent, slow or cure #Alzheimers. But the presence or absence of kindness fundamentally changes quality of life for people experiencing #dementia and those who are #caregiving. #quote
"Kindness is like snow—it beautifies everything it covers." 

~ Khalil Gibran
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Vilja Oired @oired.bsky.social · 18/03/2025
Gene repair inside the human body is now a reality.
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Vilja Oired @oired.bsky.social · 15/03/2025
Updated.
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Vilja Oired @oired.bsky.social · 12/03/2025
This aligns with the clinical picture and not just for dementia: a 75-year-old today is in the same shape as a 65-year-old 30–40 years ago. Possible reasons: Less smoking? Less physical labor? Fewer severe infections (vaccination/antibiotics)? Cholesterol-lowering drugs? Less pollution? …
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Vilja Oired @oired.bsky.social · 11/03/2025
Digital screen time and myopia risk: Under 1 hour/day relatively safe, but risk increases 21% for each extra hour.. 👓 jamanetwork.com/journals/jam...
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Vilja Oired @oired.bsky.social · 25/02/2025
A review on Hospital at Home. From my experience: Person-centered care drives satisfaction, familiar surroundings reduce delirium&other risk in seniors AND natural activity at home accelerates rehabilitation - partly by preventing deterioration in the first place.
academic.oup.com
Supporting older people through Hospital at Home care: a systematic review of patient, carer and healthcare professionals’ perspectives
AbstractIntroduction. Hospital at Home provides hospital-level type care at home, both remote and face-to-face by a multidisciplinary team of healthcare pr
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Vilja Oired @oired.bsky.social · 25/02/2025
Innovation & adaptation: Why do we need crises like war to drive significant changes and improvements in healthcare systems? Are we so risk-averse that only extreme pressure compels us to change?
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Vilja Oired @oired.bsky.social · 24/02/2025
A study in The Lancet Healthy Longevity reports that a personalised home-based interventions - encompassing physical, social and/or dietary activities - reduced emergency hospital admissions by 35% in older adults with mild frailty.
thelancet.com
Clinical and cost-effectiveness of a home-based health promotion intervention for older people with mild frailty in England: a multicentre, parallel-group, randomised controlled trial
HomeHealth is a safe intervention with a high probability of cost-effectiveness, driven by a reduction in unplanned hospital admissions. HomeHealth should be considered as a health promotion intervent...
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Vilja Oired @oired.bsky.social · 22/02/2025
This could probably be used to make any screening much more effective and targeted. By using LLM to select a screening population that are more likely to benefit from the screening.
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Vilja Oired @oired.bsky.social · 18/02/2025
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Vilja Oired @oired.bsky.social · 11/02/2025
Nature Medicine: A man with an early-onset Alzheimer’s gene and a brain full of amyloids should have developed dementia by 50, but showed no symptoms at 70! 👀 Interestingly, the typical tau changes were missing, strengthening argument that tau, not amyloid, drives cognitive decline.
nature.com
A man was destined for early Alzheimer’s ― these genes might explain his escape
Scientists identify nine genetic variants that could have helped a man avoid dementia at least two decades longer than expected.
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Vilja Oired @oired.bsky.social · 09/02/2025
An aging population will drive rising healthcare costs. Research should absolutely prioritize this area, not just for health reasons, but also because it makes economic sense.
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Vilja Oired @oired.bsky.social · 04/02/2025
Oh my Gut! - Bacteria (S. aureofaciens Tü117) in GI tract behind hypertension 👀
cell.com
Targeting gut S. aureofaciens Tü117 serves as a new potential therapeutic intervention for the prevention and treatment of hypertension
Zhou et al. reveal that the S. aureofaciens Tü117-α-lipomycin axis is correlated with HSD and an increase in BPs. Mechanistically, α-lipomycin causes vasodilation impairment involving TRPV4 -mediated ...
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Vilja Oired @oired.bsky.social · 04/02/2025
Review study: SGLT2 inhibitors & GLP-1 agonists are clearly cardioprotective in DM2. In elderly patients, SGLT2 inhibitors seem most effective - despite a smaller impact on glycemic control.
jamanetwork.com
Age and Sex Differences in Efficacy of Treatments for Type 2 Diabetes
This network meta-analysis assesses whether age or sex are associated with differences in the efficacy of sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide-1 receptor agonists, and dipe...
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James Deardorff @wjdeardorff.bsky.social · 30/01/2025
"Updating STEADI for Primary Care: Recommendations From the American Geriatrics Society Workgroup" (JAGS 2025) - "The proposed additional assessments address the multifactorial nature of falls, ultimately enhancing fall prevention efforts." - agsjournals.onlinelibrary.wiley.com/doi/10.1111/...
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Vilja Oired @oired.bsky.social · 31/01/2025
Tirzepatide reduced ”worsening of heart failure or cardiovascular death”. But read the result more carefully and you see that death was actually more common in the treatment group than placebo, although the difference is insignificant it would have been good to state more clearly.
nejm.org
Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity | NEJM
Obesity increases the risk of heart failure with preserved ejection fraction. Tirzepatide, a long-acting agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor...
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Vilja Oired @oired.bsky.social · 28/01/2025
Lifetime risk of dementia after age 55 years - 42%.
nature.com
Lifetime risk and projected burden of dementia - Nature Medicine
A cohort study of over 15,000 US adults found that the lifetime risk of developing dementia from ages 55 to 95 is 42%, with the highest risk in APOE ε4 carriers, women and Black adults, and projected ...
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Vilja Oired @oired.bsky.social · 28/01/2025
No clear comorbidities patterns among dementia patients.
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Vilja Oired @oired.bsky.social · 28/01/2025
What if dementia and frailty are evolutionary features—not flaws? Could they be part of an ancient design, fine-tuned over millennia to help groups, not just individuals, survive? 🧵👇 1/13
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Journal of the American Geriatrics Society (JAGS) @agsjournal.bsky.social · 23/01/2025
Disruptive events such as hip fractures or pneumonia substantially alter the clinical trajectories of people with dementia and are associated with worse outcomes than in people without dementia who experience these events. #geriatrics agsjournals.onlinelibrary.wiley.com/doi/10.1111/...
Kaplan–Meier survival curves for people with and without dementia and with and without hospitalization for (a) hip fracture or (b) pneumonia. Shaded lines indicate 95% Confidence Intervals.
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Robert Howard @profrobhoward.bsky.social · 27/01/2025
Our new paper. Why we should be suspicious of claims based on meaningful within-individual change from parallel-group trials of Alzheimer’s treatments. Avoiding causal fraud! alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com
Avoiding causal fraud in the evaluation of clinical benefits of treatments for Alzheimer's disease
Recent regulatory approvals of three amyloid-lowering monoclonal antibody therapies for the treatment of Alzheimer's disease (AD) have triggered a polarizing debate in the field on the clinical mean...
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Vilja Oired @oired.bsky.social · 21/01/2025
Advanced care planning (ACP) is one of the most critical aspects of care in geriatrics! Let's explore why ACP matters and how it ensures that older adults receive care aligned with their values. 🧵👇 1/14
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Vilja Oired @oired.bsky.social · 18/01/2025
Care delivered in corridors and storage rooms is undignified. A modern state can surely do better.
channel4.com
Patients dying in hospital corridors, damning report finds
More hospital beds were occupied last week than at any point so far this winter, according to new figures which show just how far the NHS in England continues to be under enormous pressure.
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Vilja Oired @oired.bsky.social · 18/01/2025
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Vilja Oired @oired.bsky.social · 17/01/2025
Gene Therapy Prediction: < 5 years - Used in hundreds of diseases where other treatments are often inadequate. You’ll hear “revolutionary” a lot. 5-10 years - Trust is built due to fantastic results and minimal side effects. 10-15 years - Expanded to address common diseases. 2040 - Widespread use.
nature.com
RNA gene therapies offer hope for millions with high cholesterol
Base editing, antisense oligonucleotides and siRNA therapies that target low-density lipoprotein and the genes encoding molecules that regulate it are being tested in several clinical trials.
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