Meet the next generation of leaders in bioconjugate chemistry and learn about their research, ideas, and aspirations for the field’s future.

Aptamer-based dye-displacement assays offer a simple, rapid, and robust approach for detecting analytes via a visible color change. These assays utilize a dye molecule that binds to aptamers in a mono...

Dehydroalanine derivatives are valuable building blocks in organic and biomolecular chemistry fields, and their scalable synthesis represents unmet needs. This work examined previously reported N-to-O...

Because of its chemical inertness, phenylalanine is one of the proteinogenic amino acids that does not have many chemical labeling methods for, particularly in unprotected peptide substrates. Inspired...

Diketopiperazines (DKPs) are considered essential in many life forms, but their prebiotic importance has not been fully understood. This review aims to discuss prebiotic organic chemistry for experim...

Gaseous reagents are an emerging class of bioconjugation reagents that can offer alternative selectivity paradigms for the construction of precise bioconjugates. A variety of both inert and highly re...

Chemical tools have allowed the interrogation of molecular events in biological systems through the realization of additive-free labeling approaches such as strain-promoted chemistry. Although design ...

Catalytic principles of synthetic organic chemistry have been increasingly applied to chemical modification of proteins during the recent years. This review article describes how seven types of catal...

Serine-targeting protein bioconjugation has been a formidable challenge because of the modest reactivity of the alkyl alcohol group in aqueous media. This work demonstrates a biomolecule-compatible, ...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Writing is an essential component of scientific activity. As such, it is necessary to develop strategies to provide equitable training opportunities for science writing. In order to provide learners with ways to improve their writing regardless of their language background and/or institutional and departmental environments, this article describes a self-learning strategy, Contextual Analysis of Scientific Publications for Advancing writing Skills (CASPArS), that employs contextual analysis of top scientists’ publications. By using full-text search software to analyze several hundred selected publications, the CASPArS method affords a visual representation of proper usage of words/phrases of interest, facilitating learners to understand writing patterns and rules in leading scientific papers. The utility of the method has been demonstrated with several examples by using 500 non-open-access papers of synthetic organic chemistry and chemical biology fields from various journals such as Nature and Science. In order to increase the accessibility of the method for diverse communities around the world, a free-search software sin3rou and 500 open-access chemistry papers (e.g., ACS Central Science and Chemical Science) by 150 U.S. researchers have been included in the Supporting Information (available online with the full paper). Using this CASPARS strategy, learners/students are able to develop appropriate writing through “professors’ eyes” by taking advantage of established scientific writers’ experience and knowledge of language usage.